Clinical Investigation of Peste des Petits Ruminants Outbreak in Sheep and Goats at Islamabad, Pakistan

Ullah, Riasat Wasee

doi:10.14737/journal.rjvp/2014/2.1s.8.10

Cited by 3 publications

(2 citation statements)

References 10 publications

(10 reference statements)

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“…Rates of morbidity and mortality are very high that can reach up to 80%–90% and 50%–80%, respectively (Abubakar, Jamal, Hussain, & Ali, 2008; Abubakar, Jamal, Khan, & Ali, 2010; Abubakar et al., 2016; Manzoor et al., 2018; Zahur et al, 2009). It is also reported that morbidity and mortality rates are high in local breeds of sheep and goat than imported breeds (Khan et al., 2018; Ullah et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Genetic characterization of peste des petits ruminants virus (Pakistani isolates) and comparative appraisal of diagnostic assays

Manzoor¹,

Abubakar²,

Zahur³

et al. 2020

Transbound Emerg Dis

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This study was designed to characterize N gene sequences of peste des petits ruminants virus (PPRV) isolates circulating in Pakistan and to evaluate the efficacy of available diagnostic assays on local isolates. During the study period, a total of sixty PPR outbreaks were investigated. A total of 20 selected samples from these outbreaks were sequenced for N gene. The result analysis and the phylogenetic trees indicated two different viral groups in N gene: one was closer to China and Tajikistan, while other group was similar to isolates from Iran and Saudi Arabia. Efficacy of three commercially available tests for the antigen detection of PPR, that is, peste test, enzyme‐linked immunosorbent assay (ELISA) and reverse transcriptase‐polymerase chain reaction (RT‐PCR) was compared. Keeping PCR as gold standard, sensitivity was calculated as 85% and 57% and specificity was calculated as 83% and 79% for ELISA and peste test, respectively. Value of K for ELISA was 0.67 which indicates good agreement between ELISA and RT‐PCR. Value of K for peste test was 0.33 which indicates fair agreement between peste test and RT‐PCR. In conclusion, study provides premier information about the use of different diagnostic tests and molecular situation of PPRV in Pakistan.

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Section: Introductionmentioning

confidence: 99%

Genetic characterization of peste des petits ruminants virus (Pakistani isolates) and comparative appraisal of diagnostic assays

Manzoor¹,

Abubakar²,

Zahur³

et al. 2020

Transbound Emerg Dis

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“…The PPR is one of the diseases classified as Transboundary Animal Diseases (Zahur et al, 2011). The typical form of PPR is associated with anorexia, pyrexia, ulceration, necrosis of mucous membranes, sores in mouth, mucopurulant nasal and ocular discharges, pneumonia, inflammation of the gastrointestinal tract (GIT) and diarrhea (Abubakar et al, 2011;Roeder and Obi, 1999;Ullah et al, 2014). Animals of all ages are susceptible to the disease that is associated with high morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Detection of <em>Peste des Petits Ruminants</em> Virus genome in fecal material of goats after an outbreak in Punjab Province of Pakistan: A longitudinal study

Ullah

Zahur²,

Irshad³

et al. 2015

SL J Food & Agric

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Peste des Petits Ruminants (PPR) is a highly contagious viral disease of domestic and wild small ruminants causing high morbidity and mortality (up to 100%) and thus, has serious socioeconomic implications. In Pakistan, estimated losses due to PPR during the year 2012-13 were worth Pakistan Rs. 31.51 billion. Close contact between infected and susceptible animal is an important route of transmission of PPR. Therefore, carrier animals play an important role in unnoticed transmission of the disease. Limited information is available about the persistence of PPR virus in goats. Hence, the objective of the study was to investigate the persistence of PPR virus (PPRV) in goats recovered from PPR. A suspected PPR outbreak in sub-urban area of Lahore district of the Punjab Province in Pakistan was investigated. The outbreak was confirmed as PPR after analyzing appropriate samples (nasal/ocular swabs, fecal and tissue samples) collected from the infected animals. A longitudinal study was conducted over a period of 16 weeks to ascertain the persistence of PPRV in the fecal samples of recovered goats (n=96) collected at 4, 8, 12 and 16 weeks after the outbreak. Samples were analyzed using RT-PCR. Of the 96 fecal samples, 46, 37, 29 and 7 goats remained positive for PPRV genome at 4, 8, 12 and 16 weeks after recovery, respectively. The results revealed the detection of PPRV genome in goats at 16 weeks after recovery. Therefore, it can be concluded that PPR disease has a carrier potential and goats recovered from PPR infection may act as source of carrier animals.

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Peste des petits ruminants in Pakistan; past, present and future perspectives

Abubakar¹,

Irfan

Manzoor³

2015

J Anim Sci Technol

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Peste des petits ruminants (PPR) is considered to be one of the main constraints to enhancing the productivity of goats and sheep in regions where it is present and becoming endemic. PPR was recognized in Pakistan in early 1990s but got importance during the Participatory Disease Surveillance (PDS) of Rinderpest Eradication Campaign. Lot of research work has been initiated during last decade towards disease epidemiology, risk factor recognition, laboratory diagnosis, vaccination and demonstration of control strategies. Although there are ongoing projects working towards the progressive control of the disease in country yet there is need to have a national level control program for PPR. Also there is need to have comprehensive social economic surveys, disease hot spot recognition and identification of role of other species in disease transmission. With combined efforts of local and national authorities and political will, there is high likelihood that this devastating disease can be controlled and eventually eradicated in near future.

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Clinical Investigation of Peste des Petits Ruminants Outbreak in Sheep and Goats at Islamabad, Pakistan

Cited by 3 publications

References 10 publications

Genetic characterization of peste des petits ruminants virus (Pakistani isolates) and comparative appraisal of diagnostic assays

Genetic characterization of peste des petits ruminants virus (Pakistani isolates) and comparative appraisal of diagnostic assays

Detection of <em>Peste des Petits Ruminants</em> Virus genome in fecal material of goats after an outbreak in Punjab Province of Pakistan: A longitudinal study

Peste des petits ruminants in Pakistan; past, present and future perspectives

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