2021
DOI: 10.1016/j.ijid.2021.09.051
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Clinical investigation of intestinal fatty acid-binding protein (I-FABP) as a biomarker of SARS-CoV-2 infection

Abstract: Objectives SARS-CoV-2 exhibits tropism for the gastrointestinal tract, however lesions in enterocytes and their correlation with disease severity and patient prognosis are still unknown. Methods SARS-CoV-2 patients were enrolled in five medical centres in the São Paulo State, Brazil. Clinical characteristics and laboratory findings of patients were recorded. At admission, 7 th and 14 th day of hospitalisation, plasma… Show more

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Cited by 9 publications
(9 citation statements)
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“…We also observed clear differences in the systemic levels of host factors, such as I-FABP and IL-10, indicating the loss in intestinal homeostasis in post-COVID subjects compared to controls. Indeed, I-FABP has been shown to be a relevant biomarker for COVID-19 disease prognostic [44].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…We also observed clear differences in the systemic levels of host factors, such as I-FABP and IL-10, indicating the loss in intestinal homeostasis in post-COVID subjects compared to controls. Indeed, I-FABP has been shown to be a relevant biomarker for COVID-19 disease prognostic [44].…”
Section: Discussionmentioning
confidence: 99%
“…ELISA for measurements of Intestinal fatty acid-binding protein (I-FABP) and cytokines ELISA techniques were used to quantify the concentrations of I-FABP as described before [44]. IL-10, TNFa and IL-1b concentrations were determined using IL-10 ELISA kits (R&D Systems, USA) according to the manufacturer's instructions.…”
Section: Mouse Hepatitis Virus-3 Intranasal Infection and Virus Quant...mentioning
confidence: 99%
“…We also observed apparent differences in the systemic levels of host factors, such as I-FABP, indicating loss of intestinal homeostasis in post-COVID subjects compared to controls. Indeed, I-FABP is a relevant prognostic biomarker that is positively correlated with a worse prognosis for COVID-19 (Saia et al, 2021). Thus, although no significant differences in α and β-diversity were observed in the gut microbiota of post-COVID and control subjects, functional changes were observed in both patients and mice.…”
Section: Discussionmentioning
confidence: 94%
“…Importantly, serum markers of tight junction permeability and microbial translocation were significantly associated with circulating proinflammatory mediators such as IL-6, suggesting that systemic inflammation is triggered to some extent by gut barrier disruption. In addition, intestinal fatty acid binding protein (I-FABP), a protein synthesized by mature enterocytes responsible for fatty acid turnover and used as a biomarker of intestinal injury, was measured in the urine of 283 patients hospitalized for COVID-19 ( 8 , 9 ). Urinary I-FABP levels were significantly elevated compared with controls and remained high in patients’ samples two weeks after hospitalization; levels were even higher in patients with critical illness than in milder cases ( 8 ).…”
Section: Introductionmentioning
confidence: 99%
“…In addition, intestinal fatty acid binding protein (I-FABP), a protein synthesized by mature enterocytes responsible for fatty acid turnover and used as a biomarker of intestinal injury, was measured in the urine of 283 patients hospitalized for COVID-19 ( 8 , 9 ). Urinary I-FABP levels were significantly elevated compared with controls and remained high in patients’ samples two weeks after hospitalization; levels were even higher in patients with critical illness than in milder cases ( 8 ). Another study found that serum levels of zonula occludins-1 (ZO-1), a marker of structural and functional integrity of the paracellular barrier, were significantly elevated in patients with COVID-19 pneumonia but were not predictive of progression to severe respiratory failure ( 10 ).…”
Section: Introductionmentioning
confidence: 99%