Clinical Investigation of Allergic Rhinitis and Allied Conditions

Mygind, Niels

doi:10.1111/j.1398-9995.1979.tb01699.x

Cited by 19 publications

(8 citation statements)

References 34 publications

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“…Although the allergic rhinitis patient cohort had associated histories of asthma (30%, P < 0.01), eczema (19%, P < 0.20) and urticaria (17%, P < 0.30), respectively, only the asthma association was significant. Comparison of our demographic data with that of others revealed that in previously reported questionnaire studies, a positive family history was present in 50% of ‘allergic’ children sampled from a presumed Danish population [ 13]. The familial occurrence of both ‘atopy’ and allergic disorders per se is well known, but when there are no ‘atopic’ family members, 5–15% of the children are likely to be ‘atopic’.…”

Section: Discussionsupporting

confidence: 56%

Preliminary criteria for the definition of allergic rhinitis: a systematic evaluation of clinical parameters in a disease cohort (I)

Warlow

Chrishanthan³

et al. 2000

Clin Experimental Allergy

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In performing statistical analyses, we were able to rank from most to least important, the multiplicity of symptoms signs and test results. The most important symptoms and signs were identified for the first time, even though some of these were not included in our original selection criteria for defining the disease cohort i.e. sniffing, postnasal drip, oedematous nasal mucosa, impaired sense of smell, mouth breathing, itchy nose and many of the specific provocation factors.

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Section: Discussionsupporting

confidence: 56%

Preliminary criteria for the definition of allergic rhinitis: a systematic evaluation of clinical parameters in a disease cohort (I)

Warlow

Chrishanthan³

et al. 2000

Clin Experimental Allergy

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“…3 or 4 times daily. For allergic rhinitis of the sneezer type of patient, an estimate of the daily number of sneezes could possibly add to the reliability of the otherwise subjective reports on symptoms and well-being (28).…”

Section: Symptom Scores and Drug Consumptionmentioning

confidence: 99%

Adequate Clinical Trials of Immunotherapy

K¹

1982

Allergy

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“…In noninfectious rhinitis the eosinophils are the predominant inflammatory cell type found [1]. Noninfectious rhinitis includes both allergic rhinitis (AR) and nonallergic rhinitis (NAR).…”

Section: Introductionmentioning

confidence: 99%

Differences and Similarities between Allergic and Nonallergic Rhinitis in a Large Sample of Adult Patients with Rhinitis Symptoms

Lorenzo¹,

Pacor²,

Amodio³

et al. 2011

Int Arch Allergy Immunol

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Background: Allergic rhinitis (AR) and nonallergic rhinitis (NAR) may present with different clinical and laboratory characteristics. Methods: A total of 1,511 consecutive patients, aged 18–81 years, diagnosed with rhinitis, 56% females and 44% males, underwent complete allergic evaluation including skin prick test, blood eosinophil counts, nasal eosinophil counts, peak nasal inspiratory flow (PNIF) measurement and evaluation of nasal symptoms using a visual analog scale (VAS). Results: A total of 1,107 patients (73%)had AR, whereas 404 (27%) had NAR. Patients with NAR were older and predominantly female. A higher nasal eosinophils count was associated with AR and a lack of clinical response to antihistamines. AR patients had more sneezing and nasal pruritus, whereas NAR was characterized mainly by nasal obstruction and rhinorrhea. AR patients had more severe symptoms and recurrent conjunctivitis, whereas NAR patients had slightly more frequent episodes of recurring headaches as well as olfactory dysfunction. PNIF, blood eosinophil counts and VAS of nasal symptoms were higher in patients with AR. In a final logistic regression model, 10 variables were statistically different between AR and NAR: age [OR 0.97 (95% CI 0.96–0.98)], sneezing [OR 4.09 (95% CI 2.78–6.00)], nasal pruritus [OR 3.84 (95% CI 2.60–5.67)], mild symptoms [OR 0.21 (95% CI 0.09–0.49)], intermittent/severe nasal symptoms [OR 3.66 (95% CI 2.06–6.50)], VAS [OR 1.06 (95% CI 1.04–1.08)], clinical response to antihistamines [OR 22.59 (95% CI 13.79–37.00)], conjunctivitis [OR 4.49 (95% CI 2.86–7.05)], PNIF [OR 1.01 (95% CI 1.00–1.01)] and nasal eosinophil counts [OR 1.14 (95% CI 1.10–1.18)]. Receiver operating characteristic analysis showed high predictive accuracy for a model including these variables independently of the diagnosis of AR/NAR (cutoff <0.74). Conclusions: We showed that the several clinical and laboratory parameters reported above may help to reinforce or exclude the diagnosis of AR obtained with skin prick test.

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Clinical Investigation of Allergic Rhinitis and Allied Conditions

Cited by 19 publications

References 34 publications

Preliminary criteria for the definition of allergic rhinitis: a systematic evaluation of clinical parameters in a disease cohort (I)

Preliminary criteria for the definition of allergic rhinitis: a systematic evaluation of clinical parameters in a disease cohort (I)

Adequate Clinical Trials of Immunotherapy

Differences and Similarities between Allergic and Nonallergic Rhinitis in a Large Sample of Adult Patients with Rhinitis Symptoms

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