Clinical investigation into the observation that silicon carbide coating on cobalt chromium stents leads to early differentiating functional endothelial layer, increased safety and DES-like recurrent stenosis rates: results of the PRO-Heal Registry (PRO-Kinetic enhancing rapid in-stent endothelialisation)

Prospective, multi-center evaluation of a silicon carbide coated cobalt chromium bare metal stent for percutaneous coronary interventions: Two-year results of the ENERGY Registry

“…At 6 months, clinical driven TLR rate was 3.2% compared to 7.6% in MULTIBENE [14], 5.2% in a single center study [21] and 4.9% in the PRO-Heal registry [11]. MACE rate was 4.9% compared to 8.7% [19] and 5.6% [11].…”

“…Cobalt-chromium (CoCr) replaced stainless steel, allowing thinner stent struts with the associated advantages of better flexibility and reduced restenosis rates [5,8,9]. In addition, passive stent coating may further reduce restenosis rates [10,11].…”

“…In animal models, silicon carbide coating has been shown to reduce direct smooth-muscle-cell stimulation [12] and to exhibit lower adhesion and activation of blood platelets and leucocytes [11,13]. It was the aim of the present registry to evaluate the clinical safety and efficacy of this latest generation BMS in a large (N 1000 patients) multi-center prospective observational trial to evaluate if the preliminary promising data obtained with a small sample size in the MULTIBENE study [14] can be replicated in daily practice and to assess outcomes in specific pre-defined high-risk groups such as patients with diabetes, small stents, and ACS.…”

The CID Chrono™ cobalt–chromium alloy carbofilm-coated coronary stent system

“…Minor amounts of nickel, molybdenum, and chromium eluted from the stainless steel stent surface may trigger an immune and inflammatory response that can potentially result in stent thrombosis and restenosis [20,21]. Novel metallic materials for making stents, such as a Co-Cr alloy that allows for thinner struts while preserving radiopacity and radial strength seem to be promising [22][23][24]. Very recently, the first-in-man study using the Catania Coronary Stent System with Nanothin Polyzene-F (CeloNova BioSciences, Newnan, Georgia) has showed excellent preliminary results [25].…”

Endovascular Treatment of Intracranial Stenosis and Vasospasm

“…The silicon carbide coating is purported to reduce thrombus formation 6,7 , suppress platelet activation 8,9 , stimulate endothelialization 10 , and prevent corrosion. 11 The authors of this handbook wonder if silicon carbide also cures cancer and is effective as a treatment for erectile dysfunction.…”