Clinical intra‐ and interfamilial variability of cluster headache

Russell, Michael Bjørn; Andersson, Poul Gertz

doi:10.1111/j.1468-1331.1995.tb00080.x

Cited by 25 publications

(20 citation statements)

References 20 publications

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“…This result agrees with our previous survey in an Italian case series of 691 patients [5]. Russell and Andersson [8] in their study found that mean age of onset was lower in the patients' children than in their parents; the authors concluded that the presence of possible genetic components may anticipate CH onset.…”

Section: Discussionsupporting

confidence: 82%

Familial cluster headache in an Italian case series

et al. 2015

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To investigate the familial occurrence of cluster headache (CH) in a series of Italian patients, we focused on possible differences in the mean age of onset between familial and non-familial CH cases. We considered all consecutive patients referred to the Parma Headache Centre between 1975 and 2013 affected by CH; we subsequently reviewed these cases applying the ICHD3-beta criteria (785 probands, 569 men and 216 women). We identified those cases who reported at least a first-degree relative with a diagnosis of CH, which was confirmed by the clinical documentation they provided. Each one of the "familial cases" was matched by sex and age (±2 years) at the first visit to three consecutive CH patients who did not report any first-degree relative affected by CH. A positive family history of CH was found in 40 probands (5.1 %), 28 men (4.9 %), and 12 women (5.6 %). The male:female ratio was 2.3:1 among the 40 CH familial cases, while it was 2.7:1 among all the CH non-familial cases (745 patients). The mean age of onset was significantly (p < 0.01) lower in women with familial CH (28.5 years, SD 17.7 years, range 10-63 years) than in women with non-familial CH (46.7 years, SD 13.7 years, range 11-74 years); we did not find a significant age difference among men (the mean age of onset for the familial cases was 29.6 years, SD 13.6 years, range 6-63 years; while for the non-familial cases, it was 29.3 years, SD 13.2 years, range 13-59 years). Our study suggests that genetic factors may play a role in the female gender causing an earlier age of onset and a lower male-to-female sex ratio in familial cases.

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Section: Discussionsupporting

confidence: 82%

Familial cluster headache in an Italian case series

et al. 2015

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“…In the present family the occurrence of typical cluster headache, chronic pain episodes without autonomic manifestations, and episodic oculo‐nasal autonomic outbursts without pain, suggest a common pathogenetic background, probably subserved by the same genetic defect. Episodic and chronic cluster headache have been reported previously in a single family (5).…”

Section: Discussionmentioning

confidence: 81%

Cluster Headache Sine Headache: Two New Cases in One Family

2002

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We report two cases of cluster headache sine headache occurring in a family of cluster headache sufferers. A 54-year-old female, suffered for 15 years from short-lasting, right-sided attacks of eye reddening, lacrimation, rhinorrea, palpebral oedema and miosis, seven to eight times per day, in periods of 20-30 days. She did not experience headache, either with or without these phenomena. Her son suffers from periorbital, short-lasting, right-sided painful attacks accompanied by eye reddening, lacrimation, rhinorrea and nasal stiffnesss, occurring in periods of 30-35 days. Soon after the end of the current cluster period he still had daily attacks lasting 10-15 min, with the oculo-nasal autonomic phenomena only. The occurrence of cluster headache sine headache and cluster headache in the same family strongly suggests that the first condition is related to the cluster headache syndrome. Cluster headache sine headache should be considered as a subtype of the cluster headache syndrome.

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“…It is well known that sporadic cases of CH display a marked male preponderance, as mentioned in the Introduction. On the other hand, the ratio between men and women is as low as 1.2 : 1 in familial CH (23, 25–28, 59) and 2.5 : 1 in a recent British clinic population (10). A recent Italian study described a CH family with eight affected and a male : female ratio of 1 : 3 (61).…”

Section: Discussionmentioning

confidence: 99%

Familial Cluster Headache. Is Atypical Cluster Headache in Family Members Part of the Clinical Spectrum?

et al. 2005

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Familial cluster headache (CH) was analysed in 21 Swedish families. Diagnosis was made according to The International Classification of Headache Disorders 2004. We identified 55 affected, of whom 42 had episodic or chronic CH, one had probable CH and 12 had atypical symptoms. The atypical cases did not fulfil the diagnostic criteria for CH, but had clinical symptoms with more resemblance to CH than to migraine or other trigeminal autonomic cephalgia syndromes. The overall male : female ratio was 1.8:1. The overall mean age at onset was significantly lower in the second/third generation than in the first generation (mean age at onset 22 vs. 31 years, SD +/- 7 vs. 13 years; P < 0.01). This may be anticipation or selection bias, since individuals with late age at onset from the second/third generation may not yet have symptoms. The prevalence of migraine was 24% (13/55), i.e. similar to the prevalence in the general population. The high incidence of atypical CH cases in the Swedish families with other members affected with CH may suggest that the spectrum of CH is broader than previously thought. We suggest that atypical CH in CH families may represent an expanded spectrum of the disease with a common aetiology, i.e. a common genetic background.

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Clinical intra‐ and interfamilial variability of cluster headache

Cited by 25 publications

References 20 publications

Familial cluster headache in an Italian case series

Familial cluster headache in an Italian case series

Cluster Headache Sine Headache: Two New Cases in One Family

Familial Cluster Headache. Is Atypical Cluster Headache in Family Members Part of the Clinical Spectrum?

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