Clinical-Instrumental patterns of neurodegeneration in Essential Tremor: A data-driven approach

Parkinsonism and tremor syndromes

“…Thus, instead of referring to these disorders as "ET plus" we may simply acknowledge that there are different subtypes of ET. For example, one recent study, using clinical, kinematic, and neuropsychological measures, identified a subgroup of ET patients characterized by the presence of gait and mobility impairment, midline tremor, cognitive decline and retinal degeneration, possibly representing a neurodegenerative subtype of ET [146].…”

Tremor Syndromes: An Updated Review

“…However, the new classification describes ET as a tremor “syndrome.” This change has stimulated scientific debates as to whether ET should be regarded as a “disease” or a “syndrome” or whether the various variants of ET should be simply considered subtypes, such as ET-PD, ET-dystonia, ET-ataxia, and other, since one may with time evolve into another ( 10 , 183 – 185 ). A recent study using multimodal investigations, including objective gait assessment, neuropsychological assessment, and optical coherence tomography (OCT) for retinal thickness measurement, provided objective evidence for the existence of two ET subtypes ( 186 ). Using cluster analysis one subtype, characterized by midline tremor, cognitive decline and thin retinal inner layer, suggests that this subtype of ET is more likely to be associated with neurodegeneration.…”

Perlas Clínicas en Neurología

“…Este cambio ha estimulado debates científicos sobre si la TE debe considerarse como una "enfermedad" o un "síndrome" o si las diversas variantes de la TE deben considerarse simplemente subtipos, como TE-PE, TE-distonía, TE-ataxia, y otro, ya que uno puede evolucionar con el tiempo en otro ( 10 , 183 -185). Un estudio reciente que utilizó investigaciones multimodales, incluida la evaluación objetiva de la marcha, la evaluación neuropsicológica y la tomografía de coherencia óptica (TCO) para medir el grosor de la retina, proporcionó evidencia objetiva de la existencia de dos subtipos de TE ( 186 ). Usando el análisis de conglomerados, un subtipo, caracterizado por temblor en la línea media, deterioro cognitivo y capa interna retiniana delgada, sugiere que este subtipo de TE tiene más probabilidades de estar asociado con la neurodegeneración.…”