Clinical Improvement of Pityriasis Rubra Pilaris With Combination Etanercept and Acitretin Therapy

Treatment of refractory adult‐onset pityriasis rubra pilaris with TNF‐alpha antagonists: a case series

“…Infliximab monotherapy proved equally effective in one adult‐onset type I PRP patient and in one patient of classic type III juvenile PRP 12 . Etanercept monotherapy or in combination with steroids was successfully used in two cases of type I PRP, resistant to traditional therapy 9,13 . Lack of efficacy of infliximab and acitretin combination therapy was reported by Lu et al.…”

Infliximab monotherapy as first-line treatment for adult-onset pityriasis rubra pilaris: Case report and review of the literature on biologic therapy

“…Of note, the first case of type III classic juvenile-onset PRP successfully treated with infliximab has recently been reported, 12 and the first two cases of type I PRP treated successfully with combination etanercept and acitretin therapy have emerged. 13,14 The T cell modulator efalizumab has been suggested to improve the disease in a 10-year-old boy unresponsible to multiple common therapies 15 but to exacerbate it in an adult patient. 16 In summary, the above listed cases with TNF-a inhibitors propose a significant response to anti-TNF-a therapy when used in combination therapy and/or in pretreated patients.…”

Pityriasis rubra pilaris: algorithms for diagnosis and treatment

“…To date, a total of 16 patients with PRP who were treated with etanercept have been reported. These patients were treated with a dose of 25–50 mg twice per week, and at least seven of them had a combined therapy of etanercept and acitretin, methotrexate and UVA1 . However, two of the four patients described by Garcovich et al .…”