Clinical improvement of photoaging-associated facial hyperpigmentation in Korean skin with a picosecond 1064-nm neodymium-doped yttrium aluminum garnet laser

Kim, Young Jae; Suh, Hyun Yi; Choi, Myoung Eun; Jung, Chang Jin; Chang, Sung Eun

doi:10.1007/s10103-020-03008-z

Cited by 17 publications

(24 citation statements)

References 18 publications

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“…Our observations in the present study are similar to previous studies using fractionated 755 [23] and 1064‐nm [22,40] picosecond lasers for the treatment of atrophic acne scars. These modalities were reported to also provide improvement [22] of postinflammatory erythema (PIE; Fig.…”

Section: Discussionsupporting

confidence: 92%

“…Mottled hypopigmentation or confetti‐like hypopigmentation is a permanent adverse effect reported in patients treated with low‐fluence 1064‐nm Q‐switched Nd:YAG laser toning [38,39]. Similar to the observation of a recent study in Koreans [40], our study likewise did not have any patients who developed punctate hypopigmentation after successive treatments with picosecond laser toning. Theoretically, a predominant photomechanical effect with a lesser degree of photothermal damage by picosecond laser application would reduce epidermal injury and non‐specific thermal damage to the neighboring structures [41,42].…”

Section: Discussionsupporting

confidence: 87%

“…5) [22,45] and PIH (Fig. 6) [40,46] caused by acne. PIE results from microvascular dilatation induced by inflammatory acne, which leads to an increased number of erythrocytes within the microcapillaries [47].…”

Section: Discussionmentioning

confidence: 99%

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Objective and Long‐Term Evaluation of the Efficacy and Safety of a 1064‐nm Picosecond Laser With Fractionated Microlens Array for the Treatment of Atrophic Acne Scar in Asians

et al. 2020

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Background and Objective Fractional 1064‐nm picosecond‐domain laser has recently been utilized for the treatment of atrophic acne scars and showed promising results. However, data on the safety and efficacy of this procedure in dark‐skinned patients are limited. This prospective, self‐controlled study was conducted to objectively evaluate the safety and efficacy of a 1064‐nm picosecond laser coupled with a microlens array (MLA) for the treatment of atrophic acne scars on Asian skin. Study Design/Materials and Methods Twenty‐six subjects of Fitzpatrick skin types (FSTs) III and IV with atrophic acne scars were enrolled. All subjects were treated with a 1064‐nm picosecond laser (spot size of 8 mm, fluence of 1.0 J/cm2, a repetition rate of 10 Hz) in combination with the MLA handpiece for an average of three passes, for 6 monthly sessions. Objective (measurement of scar volume using three‐dimensional (3D) photography and skin roughness analysis using ultraviolet A‐light video camera) and subjective (clinical evaluation by two blinded dermatologists) assessments were obtained at baseline and at 1, 3, and 6 months after the final treatment. Results Statistically significant reduction of the scar volume from baseline at 1, 3, and 6 months after the final treatment were observed by 3D photography and ultraviolet A‐light video camera. At the 6‐month follow‐up, 50% (13 of 26) of the subjects were rated as having at least 50% improvement of the scars. The rate of improvement significantly increased from the 1‐month follow‐up to the 6‐month follow‐up (P = 0.013). Similarly, at the 6‐month follow‐up, the scar volume (P = 0.024) and skin roughness (P = 0.001) also significantly improved, in comparison with the baseline. Mild postinflammatory hyperpigmentation (PIH) was observed to develop in approximately 18% of all the treatment sessions. All cases of PIH were temporary and resolved within 4 weeks on average. Conclusions The 1064‐nm picosecond laser with MLA is a safe therapeutic alternative for the treatment of atrophic acne scars in dark‐skinned individuals. Lasers Surg. Med. © 2020 Wiley Periodicals LLC

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 87%

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Objective and Long‐Term Evaluation of the Efficacy and Safety of a 1064‐nm Picosecond Laser With Fractionated Microlens Array for the Treatment of Atrophic Acne Scar in Asians

et al. 2020

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“…20 3 | RESULTS (Table 1). There were 2 RCTs, 22,23 3 single-arm trials, [24][25][26] and 3 case series, [27][28][29] for a total of 200 patients.…”

Section: Discussionmentioning

confidence: 99%

Treatment of pigmentary disorders using picosecond laser in Asian patients: A meta‐analysis and systematic review

Dong

Wang

Yuan

et al. 2021

Dermatologic Therapy

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There were many studies evaluating the effect of picosecond (PS) lasers, but no meta‐analysis examined the effects of PS laser in the treatment of pigmentary disorders in Asians. The aim of this article was to review the before‐after effect of PS laser in Asians for the treatment of pigmentary disorders. PubMed, Embase, and Cochrane library were searched for articles published up to May 2020. The evaluations were summarized into a 4‐point scale that ranged from <25% (poor), 25%‐50% (fair), 50%‐75% (good), and 75%‐100% (excellent). Effect sizes (ESs) were calculated according to laser wavelengths and lesion types. There were two randomized controlled trials, three single‐arm trials, and three case series, with 200 patients. At 3 months after treatment, of all included patients, 3% (95%CI: 1%‐6%) were evaluated as poor or worse, 9% (95%CI: 2%‐21%) as fair, 29% (95%CI: 12%‐50%) as good, and 56% (95%CI: 28%‐83%) as excellent. The 532 and 1064, and 755 nm PS lasers had similar ESs across all four response groups. This meta‐analysis suggested that 56% of Asian patients who underwent PS laser for the treatment of pigmentary disorders were evaluated as “excellent” about the pigment clearance by a dermatologist at least 3 months after treatment.

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“…Human skin, unlike other organs, undergoes photoaging processes in addition to natural aging, which ultimately leads to aging-associated pigmentary changes. The acquired benign hyperpigmentation disorders associated with aging include a wide range of diseases such as lentigo, melasma, and post-inflammatory hyperpigmentation (PIH) [ 1 ]. Among them, senile lentigo is caused by a chronic exposure to ultraviolet radiation (UVR), resulting in a characteristic hyperpigmented basal epidermal layer [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of 300 μm Needle-Depth Fractional Microneedling Radiofrequency on the Treatment of Senescence-Induced Aging Hyperpigmentation of the Skin

Lee

Kim

Lee

et al. 2021

IJMS

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Aging-associated dermatological pigmentary diseases are associated with accumulation of senescence cells and the disruption of basement membrane due to chronic ultraviolet radiation (UVR) exposure. Our study is on the synergistic effect of the novel 300 μm needle-depth fractional microneedling radiofrequency (FMR) treatment and conventional Q-switched ND:YAG laser on aging-associated hyperpigmentation of the skin. The prospective controlled clinical trial of 25 Asian women revealed significantly higher improvements not only on wrinkles, but also on hyperpigmentation. Additional ex vivo study revealed significant reduction of pro-melanogenic markers as well as senescent keratinocytes, while increased expression of collagen type IV on the epidermal basement membrane, after additional FMR treatment on UV-irradiated human tissues. These results demonstrate that 300 μm needle-depth FMR might effectively remove senescent keratinocytes that secrete pro-melanogenic markers, and repair disrupted basement membrane, therefore preventing constant hyperpigmentation of the aged skin.

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Clinical improvement of photoaging-associated facial hyperpigmentation in Korean skin with a picosecond 1064-nm neodymium-doped yttrium aluminum garnet laser

Cited by 17 publications

References 18 publications

Objective and Long‐Term Evaluation of the Efficacy and Safety of a 1064‐nm Picosecond Laser With Fractionated Microlens Array for the Treatment of Atrophic Acne Scar in Asians

Objective and Long‐Term Evaluation of the Efficacy and Safety of a 1064‐nm Picosecond Laser With Fractionated Microlens Array for the Treatment of Atrophic Acne Scar in Asians

Treatment of pigmentary disorders using picosecond laser in Asian patients: A meta‐analysis and systematic review

Synergistic Effect of 300 μm Needle-Depth Fractional Microneedling Radiofrequency on the Treatment of Senescence-Induced Aging Hyperpigmentation of the Skin

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