Clinical importance of late recurrence in soft-tissue sarcomas

Jf, Gibbs; Rj, Lee; Dl, Driscoll; Be, McGrath; Er, Mindell; Wg, Kraybill

doi:10.1002/(sici)1096-9098(200002)73:2<81::aid-jso5>3.0.co;2-9

Cited by 21 publications

(14 citation statements)

References 23 publications

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“…All these factors impacted our ability to provide for statistical analyses and strong conclusions. Local recurrence occurred in 6% of our patients, which stands at the lower end of previously reported numbers [6,9,17,27]. Our success in achieving local control reflects the comprehensive approach of a multidisciplinary team and illustrates the special character recurrent tumors exhibit.…”

Section: Discussionsupporting

confidence: 55%

“…Specialized multidisciplinary teams, using sophisticated imaging modalities, appropriate limb salvage techniques, and neoadjuvant or adjuvant therapies, have reported local recurrence for soft tissue sarcoma of the trunk and extremities ranging from 7% to 15% [6,9,17,27]. Overall survival rates, disappointingly, have not improved along with local control [1,15,29].…”

Section: Introductionmentioning

confidence: 99%

“…Local recurrences resulting from inadequate treatment have reported better prognosis than those occurring after a more comprehensive approach, with 5-year survival figures of 50% and 32%, respectively [1,11,22]. Moreover, certain patient characteristics such as male gender, high histologic grade, larger size of the primary tumor, number of recurrences, and short time delay to recurrence are reportedly signs of worse prognosis [7,9,11,14,16]. A nomogram and other prognostic index were recently proposed to help predict survival after local recurrence [14,21].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Local Recurrence After Initial Multidisciplinary Management of Soft Tissue Sarcoma: Is there a Way Out?

Abatzoglou

Turcotte

Adoubali

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Local Recurrence After Initial Multidisciplinary Management of Soft Tissue Sarcoma: Is there a Way Out?

Abatzoglou

Turcotte

Adoubali

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…4,8,9 Based on this observation, patients with STS and synchronous metastases should have a dismal prognosis.…”

mentioning

confidence: 93%

The Treatment and Outcome of Patients With Soft Tissue Sarcomas and Synchronous Metastases

Kane

Finley

Driscoll

et al. 2002

Sarcoma

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Most primary tumors were >/=10 cm (58%), high-grade histology (77%), and located on the extremity (60%).The most frequent site of metastatic disease was the lung (63%); 27% of patients had metastases to >/=2 organ sites. Surgery to the primary tumor was performed in 94% of patients (n = 45) and 68% had additional radiation therapy (n = 32). Thirty- five percent of patients underwent at least one metastastectomy (n = 17). Chemotherapy was administered to 90% of patients (n = 43); 31% received >/=3 different regimens (n = 15) and 25% were given intra-arterial or intracavitary therapy (n = 12). Median overall survival was 15 months with a 21% 2-year survival. Local control of the primary tumor was achieved in 54% (n = 26), and metastastectomy was performed in 35% (n = 17). No analyzed factors were associated with an improvement in overall survivalConclusions: Despite multiple poor prognostic factors, the survival of patients with STS and metastases is comparable to those who develop delayed metastatic disease. However, unlike patients who present with metachronous disease, there was no improved survival observed for patients treated with metastastectomy. Consequently, treatment for patients with STS and synchronous metastases should be approached with caution. Surgical management of STS with synchronous metastases must be considered palliative and should be reserved for patients requiring palliation of symptoms. Patients must also be well informed of the noncurative nature of the procedure.

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“…Einzelne Autoren raten, die bildgebende Nachkontrolle auf klinisch schlecht evaluierbare Fälle oder Hochrisikopatientenzubeschränken [14,68]. Zudem nimmt das Risiko von Weichteilsarkompatienten für ein Lokalrezidiv nach den ersten Jahren ab [19,32,52].…”

Section: Bildgebungsstrategien Für Die Nachkontrolleunclassified

Weichteilsarkome: Wie lassen sich posttherapeutische Veränderungen von Rezidiven unterscheiden?

Noebauer-Huhmann

Grieser

2017

Radiologe

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Die Diagnostik und Therapie von Patienten mit Weichteiltumoren konnte in den letzten Jahrzehnten verbessert werden, auch durch interdisziplinär in Tumorboards abgesprochenes optimiertes und standardisiertes Vorgehen [10,18,25,36,92]. Dadurch konnten bei Extremitätensarkomen sehr niedrige Lokalrezidivraten von nur 4,1 % nach 5 Jahren erreicht werden, in einer anderen Studie mit extremitätenerhaltender Resektion und postoperativer Radiatio Raten von 9 % nach 5 bzw. 12 % nach 10 Jahren [25,60] [23,56,60,99].

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Clinical importance of late recurrence in soft-tissue sarcomas

Cited by 21 publications

References 23 publications

Local Recurrence After Initial Multidisciplinary Management of Soft Tissue Sarcoma: Is there a Way Out?

Local Recurrence After Initial Multidisciplinary Management of Soft Tissue Sarcoma: Is there a Way Out?

The Treatment and Outcome of Patients With Soft Tissue Sarcomas and Synchronous Metastases

Weichteilsarkome: Wie lassen sich posttherapeutische Veränderungen von Rezidiven unterscheiden?

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