Clinical importance of cine-MRI assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction: a retrospective study of 33 patients

Fuyuki, Akiko; Ohkubo, Hidenori; Higurashi, Takuma; Iida, Hiroshi; Inoh, Yumi; Inamori, Masahiko; Nakajima, Atsushi

doi:10.1007/s00535-016-1251-8

Cited by 32 publications

(25 citation statements)

References 24 publications

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“…These findings place even more emphasis on the stimulation protocol being necessary in MRI based dysmotility research. It is likely that the young healthy volunteers in our study display low variation, but motility ranges in CIPO patients will vary greatly and applying this test in a disease group will help contextualize our findings.…”

Section: Discussionmentioning

confidence: 96%

“…MRI is non‐invasive, safe and widely available and, coupled with advances in post‐processing technologies, enables rapid and repeatable quantification . Encouragingly, the first steps toward clinical implementation have been taken with dynamic motility imaging now being routine in various centers and with several prospective clinical studies being published …”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11] Encouragingly, the first steps toward clinical implementation have been taken with dynamic motility imaging now being routine in various centers and with several prospective clinical studies being published. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] The gastrointestinal tract is complex, undergoing fasted and fed contractile cycles that take place over hours, such as the migrating motor complex. 20 It is not practical to perform prolonged MRI imaging of the intestine in a clinical setting.…”

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confidence: 99%

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Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel

Jonge

Menys

Rijn

et al. 2018

Neurogastroenterology Motil

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Objective MRI is increasingly used to evaluate small bowel contractility. The objective of this study was to validate a clinically practical stimulation test (300‐kcal meal) for small bowel motility. Methods Thirty‐one healthy subjects underwent dynamic MRI to capture global small bowel motility after ±10h fasting, of which 15 underwent bowel preparation consisting of 1 L 2.5% mannitol solution and 16 did not. Each subject underwent (1) a baseline motility scan (2) a food challenge (3) a post‐challenge scan, and (4) second post‐challenge scan (after ±20 minutes). This protocol was repeated within 2 weeks. Motility was quantified using a validated motility assessment technique. Key Results Motility in prepared subjects at baseline was significantly higher than motility in unprepared subjects (0.36 AU vs 0.18 AU, P < 0.001). In the prepared group, the food challenge produced an 8% increase in motility (P = 0.33) while in the unprepared subjects a significant increase of 30% was observed (P < 0.001). Responses to food remained insignificant (P = 0.21) and significant (P = 0.003), for the prepared and unprepared subjects, respectively, ±20 minutes post food challenge. These results were confirmed in the repeated scan session. Conclusion & Inferences A significant response to a 300‐kcal meal was measured within 10 minutes in unprepared bowel, supporting the clinical use of this challenge to provoke and assess motility changes. A caloric challenge did not produce an observable increase in motility in mannitol prepared subjects.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel

Jonge

Menys

Rijn

et al. 2018

Neurogastroenterology Motil

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“…The small bowel contractions in CIPO patients were found to be significantly weakened compared to IBS patients and healthy subjects . The results of a subsequent study in CIPO patients suggest that dynamic MRI is useful for the evaluation of the severity of CIPO by the prediction of severe clinical features . These findings were confirmed by a study in which the reader was blind to any clinical information, demonstrating a significantly decreased small bowel motility in CIPO patients compared to controls .…”

Section: Clinical Implementationmentioning

confidence: 68%

“…50 The results of a subsequent study in CIPO patients suggest that dynamic MRI is useful for the evaluation of the severity of CIPO by the prediction of severe clinical features. 51 These findings were confirmed by a study in which the reader was blind to any clinical information, demonstrating a significantly decreased small bowel motility in CIPO patients compared to controls. 23 Additionally, it was found that the response to a prokinetic drug may differ according to disease phenotype.…”

Section: Gi Motility Disorders and Functional Bowel Disordersmentioning

confidence: 76%

Evaluation of gastrointestinal motility with MRI: Advances, challenges and opportunities

Jonge

Smout

Nederveen

et al. 2017

Neurogastroenterology Motil

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Dynamic magnetic resonance imaging (MRI) of gastrointestinal motility has developed rapidly over the past few years. The non-invasive and non-ionizing character of MRI is an important advantage together with the fact that it is fast and can visualize the entire gastrointestinal tract. Advances in imaging and quantification techniques have facilitated assessment of gastric, small intestinal, and colonic motility in a clinical setting. Dynamic MRI is used in the stomach to measure frequency and amplitude of antral contractions. [3][4][5] It is used for the small bowel to look at segmental and global motility using frequency measures and surrogate measures. [6][7][8][9][10][11][12] In the colon it has been applied to assess motion and velocity of contents, wall motion and to study motility using surrogate measures. 13-17 So far there has been a paucity of validation studies. To our knowledge there is only one study in which dynamic MRI findings were compared to manometry, demonstrating 100% correlation between visualized colonic movements and intraluminal pressure changes. 17 The clinical value of dynamic MRI is under evaluation for pathologies like inflammatory bowel disease (IBD), chronic intestinal pseudo-obstruction (CIPO) and constipation. they quantified small bowel motility using dynamic MRI. 18 In this review we discuss the challenges and opportunities in evaluating gastrointestinal motility with dynamic MRI. The first part of this review summarizes the technical aspects of the dynamic MRI technique; the second part discusses the observations made by applying the described

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Intestinal Pseudo‐Obstruction (Ogilvie's Syndrome)

Chang

Heriot

2019

Evidence‐based Gastroenterology and Hepatology 4e

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Clinical importance of cine-MRI assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction: a retrospective study of 33 patients

Abstract: Cine-MRI is useful in predicting severe clinical features in patients with CIPO, and in detecting slightly impaired small contractility that cannot be detected on CT.

Cited by 32 publications

References 24 publications

Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel

Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel

Evaluation of gastrointestinal motility with MRI: Advances, challenges and opportunities

Intestinal Pseudo‐Obstruction (Ogilvie's Syndrome)

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