Abstract:Background
Pulmonary complications are common among patients who have undergone major oral cancer surgery with microvascular reconstruction. Current literatures focused on early-onset pneumonia in the postoperative acute stage. In contrast, we are aiming to identify the clinical importance and the risk factors associated with late-onset pneumonia in oral cancer patients after acute stage.
Methods
In total, 195 patients were included from May 2014 to Dec… Show more
“…While concomitant chemoradiation is a mainstay of treatment for patients with CLOCP, surgery is a significant component of the treatment regimen in approximately 50–80% of cases [ [3] , [4] , [5] , [6] , [7] ]. However, these treatment modalities lead to extended hospital stays, healthcare-associated infection (HAI), and increased financial constraints [ [8] , [9] , [10] , [11] , [12] ]. HAI initiates enormous burden leading to morbidity and mortality among CLOCP patients [ [10] , [11] , [12] ].…”
Section: Introductionmentioning
confidence: 99%
“…However, these treatment modalities lead to extended hospital stays, healthcare-associated infection (HAI), and increased financial constraints [ [8] , [9] , [10] , [11] , [12] ]. HAI initiates enormous burden leading to morbidity and mortality among CLOCP patients [ [10] , [11] , [12] ]. HAI is most frequently associated with acute care hospitals, ambulatory surgical centers, dialysis facilities, outpatient care, and long-term care facilities [ 13 ].…”
Introduction
The negative consequences of healthcare-associated infections (HAI) on the burden of illness (BOI) of cancer patients are well-established. However, there is a paucity of research on HAI among cancers of the lip, oral cavity and pharynx (CLOCP), and whether HAI-related BOI differed for other common solid tumors–malignant neoplasm of the colon (MNC) and malignant neoplasm of the lung (MNL).
Methods
We utilized the United States' National Inpatient Sample database 2017 to study longitudinal inpatient hospital stay of CLOCP, MNC and MNL. Patient demographics and hospital characteristics of patients were assessed, and the impact of HAI-related BOI compared based on differences in length of hospital stays (LOS), total charges during hospitalization and mortality were compared.
Findings
In 2017, of the 54,934 patients with CLOCP, 1.2% had HAI, compared to MNC (n=64,470) with 2% HAI and MNL (n=154,685) with 1.2% HAI. In adjusted multivariable regression analysis, we determined CLOCP patients with HAI had LOS of 5.6 days longer (95% CIs, 3.0–8.2 days,
P
< 0.001), and hospitalization charges of $40,341 higher (95%CIs 15,715–64,967,
P
< 0.01) than the non-HAI CLOCP patients. Mortality was not significantly different among HAI and non-HAI CLOCP patients (odds ratio: 0.80; 95%CIs 0.35–1.87,
P
= 0.6). In unadjusted analysis, LOS and total charges were higher for CLOCP-HAI patients vs. MNC-HAI or MNL-HAI patients.
Conclusion
HAI in patients with CLOCP patients were associated with an increased BOI, and this is considerably higher than observed in patients with MNC or MNL patients who had HAI.
“…While concomitant chemoradiation is a mainstay of treatment for patients with CLOCP, surgery is a significant component of the treatment regimen in approximately 50–80% of cases [ [3] , [4] , [5] , [6] , [7] ]. However, these treatment modalities lead to extended hospital stays, healthcare-associated infection (HAI), and increased financial constraints [ [8] , [9] , [10] , [11] , [12] ]. HAI initiates enormous burden leading to morbidity and mortality among CLOCP patients [ [10] , [11] , [12] ].…”
Section: Introductionmentioning
confidence: 99%
“…However, these treatment modalities lead to extended hospital stays, healthcare-associated infection (HAI), and increased financial constraints [ [8] , [9] , [10] , [11] , [12] ]. HAI initiates enormous burden leading to morbidity and mortality among CLOCP patients [ [10] , [11] , [12] ]. HAI is most frequently associated with acute care hospitals, ambulatory surgical centers, dialysis facilities, outpatient care, and long-term care facilities [ 13 ].…”
Introduction
The negative consequences of healthcare-associated infections (HAI) on the burden of illness (BOI) of cancer patients are well-established. However, there is a paucity of research on HAI among cancers of the lip, oral cavity and pharynx (CLOCP), and whether HAI-related BOI differed for other common solid tumors–malignant neoplasm of the colon (MNC) and malignant neoplasm of the lung (MNL).
Methods
We utilized the United States' National Inpatient Sample database 2017 to study longitudinal inpatient hospital stay of CLOCP, MNC and MNL. Patient demographics and hospital characteristics of patients were assessed, and the impact of HAI-related BOI compared based on differences in length of hospital stays (LOS), total charges during hospitalization and mortality were compared.
Findings
In 2017, of the 54,934 patients with CLOCP, 1.2% had HAI, compared to MNC (n=64,470) with 2% HAI and MNL (n=154,685) with 1.2% HAI. In adjusted multivariable regression analysis, we determined CLOCP patients with HAI had LOS of 5.6 days longer (95% CIs, 3.0–8.2 days,
P
< 0.001), and hospitalization charges of $40,341 higher (95%CIs 15,715–64,967,
P
< 0.01) than the non-HAI CLOCP patients. Mortality was not significantly different among HAI and non-HAI CLOCP patients (odds ratio: 0.80; 95%CIs 0.35–1.87,
P
= 0.6). In unadjusted analysis, LOS and total charges were higher for CLOCP-HAI patients vs. MNC-HAI or MNL-HAI patients.
Conclusion
HAI in patients with CLOCP patients were associated with an increased BOI, and this is considerably higher than observed in patients with MNC or MNL patients who had HAI.
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