Clinical implications of the detection of antibodies directed against domain 1 of β2-glycoprotein 1 in thrombotic antiphospholipid syndrome

Montalvão, Silmara Aparecida de Lima; Elídio, Priscila Soares; Saraiva, Sabrina da Silva; Mazetto, Bruna de Moraes; Colella, Marina Pereira; Paula, Erich Vinícius De; Appenzeller, Simone; Annichino‐Bizzacchi, Joyce Maria; Orsi, Fernanda Andrade

doi:10.1016/j.thromres.2016.10.001

Cited by 5 publications

(8 citation statements)

References 26 publications

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“…Seven of these 8 studies reported the positivity rates of anti-D1 antibodies, concordantly describing a higher prevalence of anti-D1 antibodies among women with obstetric APS as compared to controls, although this difference did not invariably attain statistical significance. 67,70–73,79,87,88 As reported in Table 2, the positivity rate of anti-D1 antibodies in women with obstetric APS ranged between 25 and 84%.…”

Section: Antibodies Against Domain 1 Of β2gpi and Obstetric Morbiditymentioning

confidence: 90%

“…Understandably, the literature on anti-D1 reactivity in relation to vascular events has flourished, 67–85 and most studies –even though not all- have confirmed that antibodies targeting D1 provide the most relevant autoantibody subpopulation in patients with thrombotic APS. A recent metanalysis considered all relevant studies, concluding that anti-D1 positivity conveys an odds ratio for thrombosis of approximately two.…”

Section: Antibodies Against Domain 1 Of β2gpi and Obstetric Morbiditymentioning

confidence: 99%

“…To date, only 8 studies assessed anti-D1 antibodies in women with aPL-related obstetric complications. 67,70–73,79,87,88 These 8 studies were in agreement with the remaining burden of literature on anti-D1 antibodies, and several well-known notions could be confirmed: positivity for anti-D1 antibodies correctly identifies patients with a diagnosis of APS; anti-D1 antibodies are associated with positive lupus anticoagulant (LA); women with three positive aPL tests display higher anti-D1 antibody titres and positivity rates compared to those double and single positive. …”

Section: Antibodies Against Domain 1 Of β2gpi and Obstetric Morbiditymentioning

confidence: 99%

“…As expected, patients with thrombotic APS were concordantly shown in all the 8 relevant studies to display higher positivity rate and higher titres of anti-D1 antibodies compared to women with obstetric APS, thus resulting in higher odds ratios for vascular events than pregnancy morbidity (Table 4). 57,70–73,79,87,88…”

Section: Antibodies Against Domain 1 Of β2gpi and Obstetric Morbiditymentioning

confidence: 99%

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16th International Congress on Antiphospholipid Antibodies Task Force Report on Obstetric Antiphospholipid Syndrome

Jesús

Benson

Chighizola

et al. 2020

Lupus

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Obstetric antiphospholipid syndrome (APS) remains a clinical challenge for practitioners, with several controversial points that have not been answered so far. This Obstetric APS Task Force met on the 16th International Congress on Antiphospholipid Antibodies in Manchester, England, to discuss about treatment, diagnostic and clinical aspects of the disease. This report will address evidence-based medicine related to obstetric APS, including limitations on our current management, the relationship between antibodies against domain 1 of β2GPI and obstetric morbidity, hydroxychloroquine use in patients with obstetric APS and factors associated with thrombosis after obstetric APS. Finally, future directions for better understanding this complex condition are also reported by the Task Force coordinators.

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Section: Antibodies Against Domain 1 Of β2gpi and Obstetric Morbiditymentioning

confidence: 90%

Section: Antibodies Against Domain 1 Of β2gpi and Obstetric Morbiditymentioning

confidence: 99%

Section: Antibodies Against Domain 1 Of β2gpi and Obstetric Morbiditymentioning

confidence: 99%

Section: Antibodies Against Domain 1 Of β2gpi and Obstetric Morbiditymentioning

confidence: 99%

See 2 more Smart Citations

16th International Congress on Antiphospholipid Antibodies Task Force Report on Obstetric Antiphospholipid Syndrome

Jesús

Benson

Chighizola

et al. 2020

Lupus

View full text Add to dashboard Cite

show abstract

“…Notably, IL has probably the widest selection of aPL assays available on its instrumentation, including assays for LA by several methods, and assays for solid-phase aPL by chemiluminescence, most typically promoted on its immunology version of the AcuStar, called the "BioFlash." 85,86 Of some additional interest, harmonization/standardization of LA testing, using clot-based procedures, seems incongruously better standardized among manufacturers than solid-phase aPL assays. [87][88][89] Similar to our call for harmonization/standardization of D-dimer immunoassays, harmonization/standardization of solid-phase immunoassays is also warranted, albeit not apparently on the current agenda of mainstream hemostasis analyzer manufacturers.…”

Section: Antiphospholipid Antibodiesmentioning

confidence: 99%

Recent Advances in Mainstream Hemostasis Diagnostics and Coagulation Testing

Favaloro

Lippi

2019

Semin Thromb Hemost

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The authors provide a narrative review of mainstream hemostasis analyzers. The review is presented in two parts. In the first part, the authors give voice to several internationally representative manufacturers of mainstream hemostasis analyzers. They ask these manufacturers to (1) answer a series of survey questions that may otherwise reflect common questions asked by users or potential users of their equipment, (2) provide a bullet list of their main focus areas, and (3) provide other information in regard to their instrumentation. The authors then offer their own personal perspective of the benefits of various aspects of such equipment, as well as a sampling of some hemostasis tests as currently available, or potentially in progress. It is hoped that this snapshot of mainstream hemostasis diagnostics and coagulation testing drives positive future changes that will ultimately provide the best outcomes for laboratories performing hemostasis assays and the patients they help diagnose and manage.

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Association between plasmatic oxidative stress and thrombosis in primary antiphospholipid syndrome

Vaz

Mazetto

Vasconcelos

et al. 2021

J Thromb Thrombolysis

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Antiphospholipid antibodies induce a pro-inflammatory and hypercoagulable state that lead to increased risk of thrombosis. Whether oxidative damage contributes thrombosis risk is a matter of debate. We evaluated the association between oxidative stress and thrombosis in primary antiphospholipid syndrome (t-PAPS). Plasma total antioxidant capacity and the levels of malondialdehyde (TBARs), carbonyl protein, and 8-isoprostane in plasma were determined in a group of patients with t-PAPS and in individuals without a history of thrombosis (controls) using commercial ELISA assays. The levels of these plasma markers of oxidative stress were compared between t-PAPS and controls using Mann–Whitney test. A total of 70 patients with t-PAPS and 74 controls were included. Overall, measurements of all plasma oxidative stress markers were similar between t-PAPS patients and controls. In a subgroup analysis, patients with t-PAPS and arterial thrombosis had a higher antioxidant capacity as compared to controls. Thrombotic PAPS was not associated with increased levels of oxidative stress markers, in comparison with individuals without thrombosis. Even though it is not possible to rule out that a mild oxidative damage, not detected by plasma markers, occurs in t-PAPS, our results suggest that measuring plasma oxidative stress markers has limited clinical relevance in t-PAPS.

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Clinical implications of the detection of antibodies directed against domain 1 of β2-glycoprotein 1 in thrombotic antiphospholipid syndrome

Cited by 5 publications

References 26 publications

16th International Congress on Antiphospholipid Antibodies Task Force Report on Obstetric Antiphospholipid Syndrome

16th International Congress on Antiphospholipid Antibodies Task Force Report on Obstetric Antiphospholipid Syndrome

Recent Advances in Mainstream Hemostasis Diagnostics and Coagulation Testing

Association between plasmatic oxidative stress and thrombosis in primary antiphospholipid syndrome

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