Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: Multicentre Registry Study of the Japanese Coronary Spasm Association

Takagi, Yusuke; Yasuda, Satoshi; Takahashi, Jun; Tsunoda, Ryusuke; Ogata, Yasuhiro; Seki, Atsushi; Sumiyoshi, Tetsuya; Matsui, Motoyuki; Goto, Toshikazu; Tanabe, Yuji; Sueda, Shozo; Sato, Toshiaki; Ogawa, Satoshi; Kubo, Norifumi; Momomura, Shin‐ichi; Ogawa, Hisao; Shimokawa, Hiroaki

doi:10.1093/eurheartj/ehs199

Cited by 197 publications

(155 citation statements)

References 40 publications

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“…Провокация коронарного спазма с введением аце-тилхолина или эргоновина -безопасная методика [249,250], при условии, что препарат инфузируют избира-тельно в левую коронарную артерию или правую коро-нарную артерию. Также описаны неинвазивне провока-ционные пробы с внутривенным введением эргоновина, с ЭхоКГ или перфузионной сцинтиграфией, дополняю-щей ЭКГ-мониторирование, которые увеличивают чув-ствительность и специфичность этих проб [251].…”

Section: диета (таблица 25)unclassified

2013 Esc Guidelines on the Management of Stable Coronary Artery Disease

Montalescot

Sechtem²,

Achenbach³

et al. 2014

Russ J Cardiol

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Section: диета (таблица 25)unclassified

2013 Esc Guidelines on the Management of Stable Coronary Artery Disease

Montalescot

Sechtem²,

Achenbach³

et al. 2014

Russ J Cardiol

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show abstract

“…An SPT is an important clinical diagnostic tool for VSA, and remains so despite reports of severe complications [3,[6][7][8][9]. These complications may be caused by prolonged hemodynamic instability, severe and prolonged myocardial ischemia, or NTG overdose.…”

Section: Journal Of Clinical and Experimental Research In Cardiologymentioning

confidence: 99%

“…Despite being clinically important, this examination can be accompanied by severe complications such as shock, ventricular fibrillation, ventricular tachycardia, and bradyarrhythmia [6][7][8][9]. A positive SPT is judged by angiographic confirmation of coronary artery spasm combined with ischemic symptoms and ECG changes [3].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of a Pressure Wire for the Diagnosis of Vasospastic Angina during a Spasm Provocation Test

Teragawa¹,

Fujii²,

Uchimura³

et al. 2017

Journal of Clinical and Experimental Research in Cardiology

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“…However, Harding et al reported that major complication rate was 0.03% (11/3447) including four patients (0.01%) with myocardial infarction and seven patients (0.02%) with ventricular tachycardia or fibrillation by carrying intravenous ER testing in patients without significant coronary artery disease or Prinzmetal's variant angina [17]. Takagi et al reported the high prevalence of arrhythmic complications during coronary spasm provocation tests in ACh test than that in ER testing (9.3% vs. 3.2%, p<0.001) [18], although our small data included in this report. The incidence of VT/VF was significantly higher in ACh tests than in ER testing (4.9% vs. 0.8%, p<0.001).…”

Section: Safety Of Three Sequential Spasm Provocation Testsmentioning

confidence: 99%

Complications of Pharmacological Spasm Provocation Tests

Miyoshi¹

2015

Angiol

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Background: We investigated the complications of spasm provocation tests, including acetylcholine (ACh) tests, ergonovine (ER) tests and adding ACh after ER tests, retrospectively. Methods:We performed 1546 ACh tests and 1114 ER tests during 23 years, including 240 adding ACh after ER tests. ACh (RCA: 20/50/(80) g, LCA: 20/50/100/(200) g) was injected incrementally over 20 seconds, whereas ER (RCA: 40 g, LCA: 64 g) was administered over 2-4 minutes. In addition, we administered adding intracoronary injection of ACh (RCA: 50/80 g, LCA: 100/200 g) after ER tests. Serious major complications were defined as ventricular fibrillation, sustained ventricular tachycardia, shock, severe hypotension (< 60 mmHg), cardiac arrest and cardiac tamponade.Results: Serious major and major complications were higher in ACh tests than ER tests (1.8% vs. 0.4%, p<0.01), whereas serious major complications were not different between ACh and ER tests (0.9% vs. 0.4%, ns). No serious major or major complications were observed in adding ACh after ER tests. Paroxysmal atrial fibrillation was not different between ACh tests and adding ACh after ER tests (16.7% vs. 12.5%, ns). Necessity of nitrates to relive provoked spasms prior to carrying other site tests were significantly higher in ER tests (6.8%) than ACh tests (2.0%) and adding ACh after ER test (2.5%). No death or irreversible complications were recognized in all three spasm provocation tests.Conclusions: Serious major complications were not different between the two agents, whereas serious major and major complications were significantly higher in ACh tests than ER tests. Although pharmacological spasm provocation tests including adding ACh after ER tests were reliable and relatively safer methods, we should perform these tests positively in the cardiac catheterization laboratory.

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Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: Multicentre Registry Study of the Japanese Coronary Spasm Association

Cited by 197 publications

References 40 publications

2013 Esc Guidelines on the Management of Stable Coronary Artery Disease

2013 Esc Guidelines on the Management of Stable Coronary Artery Disease

Usefulness of a Pressure Wire for the Diagnosis of Vasospastic Angina during a Spasm Provocation Test

Complications of Pharmacological Spasm Provocation Tests

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