Clinical implications of nonspecific pulmonary nodules identified during the initial evaluation of patients with head and neck squamous cell carcinoma

Kwon, Minsu; Lee, Sang Hoon; Lee, Yoon Se; Lee, Choong Wook; Roh, Jong–Lyel; Choi, Seung‐Ho; Nam, Soon Yuhl; Kim, Sang Yoon

doi:10.1007/s00330-017-4750-y

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…Kwon et al reported that the cumulative incidence rates of pulmonary malignancy development at 2 years after treatment of HNSCC were equivalent regardless of whether non-specific pulmonary nodules were present during the initial staging workup. 17 Advanced primary stage and primary cervical lymph node (LN) involvement were independent factors for pulmonary malignancy development, and they led to the hypothesis that the lower cervical LN near the thoracic space would be at significant risk for lung metastases based on the “cascade theory”, which infers that some adjacent sites are seeded first and that further metastases proceed in sites other than the primary site. 17 Additionally, primary cervical LN involvement was demonstrated to be a poor prognostic factor after PM for HNSCC.…”

Section: Discussionmentioning

confidence: 99%

“… 17 Advanced primary stage and primary cervical lymph node (LN) involvement were independent factors for pulmonary malignancy development, and they led to the hypothesis that the lower cervical LN near the thoracic space would be at significant risk for lung metastases based on the “cascade theory”, which infers that some adjacent sites are seeded first and that further metastases proceed in sites other than the primary site. 17 Additionally, primary cervical LN involvement was demonstrated to be a poor prognostic factor after PM for HNSCC. 5 , 6 , 18 These data suggest that primary site cervical LN involvement might have a significant effect on pulmonary metastases and might be associated with a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Survival Outcomes of Complete Pulmonary Metastasectomy for Head and Neck Squamous Cell Carcinomas

Kuroda¹,

Koyama²,

Mun³

et al. 2022

CMAR

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Purpose Metastatic head and neck squamous cell carcinoma (HNSCC) is relatively poor; however, depending on the selected cases, pulmonary metastasectomy can be a practical therapeutic option. This study aimed to identify the outcomes of complete metastasectomy based on each primary site and to investigate unfavorable prognostic factors. Patients and Methods We used the database from the Metastatic Lung Tumour Study Group of Japan. Between November 1980 and April 2017, 231 patients were deemed eligible. According to anatomy and the current epidemiology of HNSCC, the patients were divided into three groups: nasopharynx, oropharynx, and salivary gland (n = 40, Group 1), oral cavity, tongue, and paranasal sinuses (n = 69, Group 2), and larynx and hypopharynx (n = 122, Group 3). Results The 5-year overall survival after complete pulmonary metastasectomy was 58.5%, 25.0%, and 46.9% in G1, 2, and 3, respectively ( p < 0.01). Multivariate analyses revealed unfavourable prognostic factors to be G2, and pathological maximum diameter was >20 mm. Therefore, on dividing group 1 and 3 with or without diameter, the 5-year overall survival was significantly worse in HNSCC with a diameter >20 mm (n = 74) than that in the remnant (n = 88; 61.9% vs 35.5%; p < 0.01). Conclusion According to the multi-institutional Japanese data, pulmonary metastasectomy from HNSCC indicates a potential survival benefit. Oral cavity, tongue, and paranasal sinuses cancer, and tumour size (>20 mm) were poor prognostic factors for pulmonary metastasectomy from head and neck cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Survival Outcomes of Complete Pulmonary Metastasectomy for Head and Neck Squamous Cell Carcinomas

Kuroda¹,

Koyama²,

Mun³

et al. 2022

CMAR

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“…After a mean time of 18 months, another 14% of our patients developed metachronous distant metastatic outgrowth, in particular pulmonary metastases. The diagnostic gap in the pre-therapeutic identification of pulmonary metastases was recently demonstrated [ 17 ] and highlights the necessity to identify molecular markers that predict both, local and systemic tumor recurrency at the time of initial diagnosis. Recently, CXCR4 came into focus in different tumor entities and CXCR4-positivity was usually associated with local tumor growth, the occurrence of local and systemic metastases and, therefore, reduced survival parameters [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Primary tumor-associated expression of CXCR4 predicts formation of local and systemic recurrency in head and neck squamous cell carcinoma

Knopf¹,

Bahadori²,

Fritsche³

et al. 2017

Oncotarget

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ObjectivesDespite modern treatment regimens, overall survival in head and neck squamous cell carcinomas (HNSCC) is less than 50% due to local and systemic disease recurrency. The current study aims to identify molecular markers in primary tumor specimens that predict the risk for local and systemic recurrency at the time of initial diagnosis.MethodsThe study included clinic-pathological data of 1,057 HNSCC. MMP2/9, TIMP1/2, CXCR4, and CXCL12 immunohistochemistry was done in 150 randomly selected specimens. For statistics, we employed Chi square, Fisher exact, and Student's t-test. Overall survival (OS) was calculated by Kaplan–Meier and log-rank test. Prognostic variables were subsequently evaluated by Cox regression for forward selection.ResultsCXCR4 positive specimens demonstrated a significant increased risk for tumor recurrency associated death (rT: HR 10.07; p=0.001 / rN: HR 5.04; p=0.013 / rM: HR 2.49; p=0.029) when compared with their unaltered counterparts. Expression of MMP9, TIMP2, CXCR4, and CXCL12 was significantly increased in distant metastasized patients (p<0.0001) and showed significant cross-correlation. In addition, CXCR4 positivity was associated with an increased risk to die due to enhanced T or N status (T1/2 vs. T3/4: HR 5.78; p=0.017; N0 vs. N+: HR 5.18; p=0.033).ConclusionCXCR4 positivity in tumor samples at initial diagnosis were associated with reduced overall survival, in particular with respect to increasing T/N status, local and systemic recurrency.

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Head and neck cancer with synchronous nodules of the lung as a diagnostic and therapeutic challenge – A systematic review

Müller¹,

Li²,

Giger³

et al. 2023

Oral Oncology

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Clinical implications of nonspecific pulmonary nodules identified during the initial evaluation of patients with head and neck squamous cell carcinoma

Cited by 4 publications

References 21 publications

Survival Outcomes of Complete Pulmonary Metastasectomy for Head and Neck Squamous Cell Carcinomas

Survival Outcomes of Complete Pulmonary Metastasectomy for Head and Neck Squamous Cell Carcinomas

Primary tumor-associated expression of CXCR4 predicts formation of local and systemic recurrency in head and neck squamous cell carcinoma

Head and neck cancer with synchronous nodules of the lung as a diagnostic and therapeutic challenge – A systematic review

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