Clinical implications of immunologic phenotyping in cutaneous T cell lymphoma

Woringer-Kolopp Disease (Localized Pagetoid Reticulosis) or Unilesional Mycosis Fungoides?

“…The atypi¬ cal mononuclear cell infiltrate in each of seven cases was composed almost exclusively ofT lymphocytes, with an ab¬ normally elevated CD4:CD8 ratio present in two of four évaluable cases. 33 The CD8+ and CD47CD8 predominant phenotypes were not detected. Normal pan-T-cell surface antigen expression of CD2, CD3, and CD5 was present in all four cases tested.…”

Epidermal Langerhans' cell densities influence survival in mycosis fungoides and Sézary syndrome

“…This is at variance with a recent finding obtained by semiquantitative evaluation that the density of CDCpositive cells is possibly a variable with significant relationship to survival. 43 However, it appears obvious that the helper/ inducer (CDCpositive) subset comprises both malignant and reactive cells in the cutaneous infiltrates of MF and SS. Thus, this result remains doubtful.…”

Density of neoplastic lymphoid infiltrate, CD8+ T cells, and CD1a+ dendritic cells in mycosis fungoides

“…A few studies have focused on the distribution of CD8+ and CD1a+ cells and their relation with clinical behavior in MF, with conflicting results. [12][13][14][15][16][17] The aim of our study was to find a correlation, if any, between the density of TILs, LCs, and DDCs and the density, distribution, and epidermotropism of the lymphoid neoplastic infiltrate, with special emphasis on the comparison between early and more advanced MF.…”