Clinical implications of brown tumor uptake in whole-body 99mTc-sestamibi scans for primary hyperparathyroidism

Meng, Zhen; Zhu, Mei; He, Qing; Zhang, Yujie; Jia, Qiang; Tan, Jian

doi:10.1097/mnm.0b013e328347b582

Cited by 18 publications

(14 citation statements)

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“…Serum parathormone levels with a bone scan provide a highly accurate method to reach an accurate diagnosis in such cases. 7 Classically, the clinical manifestation of hyperparathyroidism has been described as "bone, stone, abdominal groans, psychic moan". 8,9 These symptoms due to hypercalcemia, excessive bone resorption, and mental troubles that comes along.…”

Section: Discussionmentioning

confidence: 99%

Brown Jaw Tumors: challenges and outcomes

Abdelrahman¹

2017

Int Surg J

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Background: Brown tumors are very rare giant cell lesions that arise as a result of hyperparathyroidism, brown tumors rarely affect the mandible and maxilla and its diagnosis and treatment is very challenging and needs a high index of suspicion. Methods: Retrospective chart review of nine cases diagnosed as brown jaw tumors treated in maxillofacial, head and neck surgery unit, department of surgery, Sohag University hospital. Results: They were 9 patients, 3 males and 6 females with a mean age of 43.3 years. Lesions were located in the mandible (4 cases), maxilla (3 cases), both mandible and maxilla (2 cases). The main presentation was a mass lesion. Clinical examination and serum parathormone, serum calcium, serum phosphorus, neck ultrasonography, parathyroid scan was used for diagnosis. Cases did excision with parathyroidectomy. There was no recurrence during a mean follow up period of 9.3 months. All patients had satisfactory results. Conclusions: All cases with osteolytic lesions in mandible or maxilla the possibility of brown tumors should be kept in mind especially if there is any manifestation of hyperparathyroidism. This report will aid in the recognition and treatment of the jaw brown tumors.

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Section: Discussionmentioning

confidence: 99%

Brown Jaw Tumors: challenges and outcomes

Abdelrahman¹

2017

Int Surg J

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“…Giant cell tumors as a manifestation of primary hyperparathyroidism are extremely rare; usually these tumors have no autonomous growth and occur only in the more advanced stages of hyperparathyroidism bone disease [5]. After appropriate treatment of hyperparathyroidism, giant cell tumors tend to regress.…”

Section: Discussionmentioning

confidence: 99%

“…Giant cell tumors may cause extensive bone resorption in the mandible, ribs, pelvis, and clavicles. These tumors usually have no autonomous growth and occur in more advanced stages of bone disease associated with hyperparathyroidism [5]. Giant cell tumors may regress after treatment of hyperparathyroidism.…”

Section: Introductionmentioning

confidence: 99%

Robotic Mediastinal Parathyroidectomy in a Patient with Maxillary Giant Cell Tumor

Al-Githmi¹

2013

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A 50-year-old woman with a maxillary giant cell tumor had primary hyperparathyroidism from a mediastinal parathyroid adenoma. Computed tomography showed a mildly enhanced, oval soft tissue nodule (2.5 × 1.5 × 1.7 cm) at the anterosuperior mediastinum. Mediastinal parathyroidectomy was performed with a 3-arm surgical robot. After surgery, the plasma parathyroid hormone level decreased markedly (before surgery, 70.5 pg/ml; after surgery, 5.5 pg/ml; normal reference range, 1.6 to 6.9 pg/ml). The 3-dimensional visualization, high-dexterity, and full range of motion of the robotic system provided an efficient and safe surgical procedure for the mediastinal tumor. The purpose of this case study is to show the feasibility and effectiveness of robot assisted dissection for mediastinal parathyroid gland and to demonstrate the giant cell tumor of the bone can regress after resection of parathyroid adenoma.

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“…There are only a few reports showing BT uptake in whole-body MIBI. [1][2][3] The first case is a 72-year-old caucasian woman, with a history of right nephrectomy for renal lithiasis at the age of 49 and a left clavicle fracture at the age of 70, who presented with an enlarging mass in the fracture site (~6 cm). Laboratory data showed an elevated serum level of calcium (sCa) of 12.…”

Section: Descriptionmentioning

confidence: 99%

“…The underlying mechanisms for the increased uptake of MIBI in BT are not fully understood and may be related to increased local inflammation/vascularisation. 3 …”

Section: Descriptionmentioning

confidence: 99%

Tc-99m sestamibi scintigraphy and primary hyperparathyroidism: uptake beyond parathyroid glands

Dias¹,

Simões‐Pereira²,

Leite

2018

BMJ Case Reports

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Clinical implications of brown tumor uptake in whole-body 99mTc-sestamibi scans for primary hyperparathyroidism

Abstract: A Tc-sestamibi whole-body scan could be used to assess brown tumors in PH, although it may be less sensitive than a bone scan. PTH possessed the best diagnostic accuracy and predictive value for a positive imaging outcome. ALP was useful for negative imaging outcome prediction.

Cited by 18 publications

References 0 publications

Brown Jaw Tumors: challenges and outcomes

Brown Jaw Tumors: challenges and outcomes

Robotic Mediastinal Parathyroidectomy in a Patient with Maxillary Giant Cell Tumor

Tc-99m sestamibi scintigraphy and primary hyperparathyroidism: uptake beyond parathyroid glands

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