Clinical implications of antifungal drug susceptibility testing of dermatophytes

Khurana, Ananta; Sardana, Kabir; Chowdhary, Anuradha; Sethia, Khushboo

doi:10.4103/idoj.idoj_253_19

Cited by 4 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common examples of superficial mycoses include dermatomycosis, candidiasis, and pityriasis versicolor. 4–7 …”

Section: Introductionmentioning

confidence: 99%

“…The most common examples of superficial mycoses include dermatomycosis, candidiasis, and pityriasis versicolor. [4][5][6][7] Dermatophytosis is mainly confined to the keratinized layers because its fungal agents are not able to penetrate into the organ or deeper tissue of healthy individuals. However, these kind's infections are also dependent on the immune status of the host, fungal agent and site of infection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiological Characterization of Dermatomycosis in Ethiopia

Araya¹,

Abuye²,

Negesso³

2021

CCID

View full text Add to dashboard Cite

Background: Superficial mycosis is common worldwide and their epidemiological characteristics are different in different geographical areas and have shown variations in the last decades. The aim of this study was to analyze and characterize the epidemiology of dermatomycosis and their causative fungi species in Ethiopia between 2015 and 2019. Methods: A laboratory-based cross-sectional study was conducted using the data of mycological examination and culture findings from all patients who visited the

show abstract

“…The most common examples of superficial mycoses include dermatomycosis, candidiasis, and pityriasis versicolor. 4–7 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiological Characterization of Dermatomycosis in Ethiopia

Araya¹,

Abuye²,

Negesso³

2021

CCID

View full text Add to dashboard Cite

show abstract

“…[ 26 39 40 41 ] This value is lower than the mean MICs for terbinafine reported from different centres across the country over the past few years and in line with the recently reported upper limit of wild-type (UL–WT) MIC of 8 μg/ml for terbinafine in Indian strains. [ 14 19 34 38 42 43 44 ] It is interesting to note that of the nine isolates from patients who failed higher dose or longer durations of terbinafine, eight had terbinafine MICs of ≥32 μg/ml. [ 34 ]…”

Section: Terbinafinementioning

confidence: 99%

Therapeutic Updates on the Management of Tinea Corporis or Cruris in the Era of Trichophyton Indotineae

Khurana,

Sharath,

Sardana

et al. 2023

Indian Journal of Dermatology

View full text Add to dashboard Cite

The emergence and spread of Trichophyton indotineae (T. indotineae) has led to a sea change in the prescription practices of clinicians regarding the management of dermatophytic skin infections. An infection easily managed with a few weeks of antifungals, tinea corporis or cruris, is now often chronic and recurrent and requires prolonged treatment. Rising resistance to terbinafine, with documented squalene epoxidase (SQLE) gene mutations, and slow clinical response to itraconazole leave clinicians with limited treatment choices. However, in these testing times, it is essential that the tenets of antifungal stewardship be followed in making therapeutic decisions, and that the existing armamentarium of antifungals be used in rationale ways to counter this extremely common cutaneous infection, while keeping the growing drug resistance among dermatophytes in check. This review provides updated evidence on the use of various systemic antifungals for dermatophytic infection of the glabrous skin, especially with respect to the emerging T. indotineae species, which is gradually becoming a worldwide concern.

show abstract