Clinical implications and treatment of dengue

Abstract

Dengue is a common pathogenic disease often proving fatal, more commonly affecting the tropics. Aedes mosquito is the vector for this disease, and outbreaks of dengue often cause mass damage to life. The current review is an effort to present an insight into the causes, etiology, symptoms, transmission, diagnosis, major organs affected, mitigation and line of treatment of this disease with special emphasis on drugs of natural origin. The disease has a potential to spread as an endemic, often claiming several lives and thus requires concerted efforts to work out better treatment options. Traditional medicine offers an alternative solution and could be explored as a safer treatment option. Development of a successful vaccine and immunization technique largely remains a challenge and a better antiviral approach needs to be worked out to complement the supportive therapy. No single synthetic molecule has found to be wholly effective enough to offer curative control and the line of treatment mostly utilizes a combination of fluid replacement and antipyretics-analgesics like molecules to provide symptomatic relief.

Knowledge on fever and its associated factors among the parents of the children who were treated as cases of dengue fever or dengue hemorrhagic fever in a tertiary care setting of a lower middle income country

“…patients with DHF [10]. In other words, timely detection of fever and general understanding of the essentials on fever are important modifiable factors influencing the outcome of dengue.…”

Molecular Diagnostics of Dengue by Reverse Transcription-Loop Mediated Isothermal Amplification (RT-LAMP) in Disposable Polyester-Toner Microdevices

“…1,2 The reemergence of sudden epidemics has been a severe problem in global health since the early 20 th century. 3,4 Rapid and efficient detection of the infection is crucial for suitable treatment as well as for appropriate control of the disease. 5 Detection of virus-specific antibodies and virus isolation are the most commonly applied diagnosis tests in resource-limited laboratories.…”

Transverse Myelitis as an Unusual Complication of Dengue Fever

“…DHF can progress to dengue shock syndrome (DSS), which is characterized by vascular leakage and multiorgan failure that can cause death. 4 A diverse range of neurological complications of DENV infections involving the central and peripheral nervous systems have been reported. These include encephalopathy, encephalitis, febrile seizures, aseptic meningitis, intracranial hemorrhages, intracranial thrombosis, subdural effusions, mononeuropathies, polyneuropathies, and GuillainBarré syndrome.…”