Clinical Implication of Quantitative Flow Ratio After Percutaneous Coronary Intervention for 3-Vessel Disease

Kogame, Norihiro; Takahashi, Kuniaki; Tomaniak, Mariusz; Chichareon, Ply; Modolo, Rodrigo; Chang, Chun Chin; Komiyama, Hidenori; Katagiri, Yuki; Asano, Taku; Stables, Rod; Fath‐Ordoubadi, Farzin; Walsh, Simon; Sabaté, Manel; Davies, Justin E.; Piek, Jan J.; Geuns, Robert‐Jan van; Reiber, Johan H. C.; Banning, Adrian P.; Escaned, Javier; Farooq, Vasim; Serruys, Patrick W.; Onuma, Yoshinobu

doi:10.1016/j.jcin.2019.08.009

Cited by 81 publications

(85 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, final stent optimization excluded the possibility of stent distortion, or stent underexpansion can be assessed easier in OCT that has a much higher resolution than IVUS. Furthermore, OCT-derived FFR can be utilized in the future to evaluate lesion severity and the residual ischemic risk after the procedure ( 69 , 70 ).…”

Section: Potential Clinical Application Of a Hybrid Ivus–oct Cathetermentioning

confidence: 99%

“…Therefore, OCT-derived fractional flow reserve (FFR) might be superior to IVUS-derived FFR or angiography-derived FFR. Although the clinical implication of these approaches still needs further validation, they may have the potential to enable a comprehensive assessment of the characteristics of a lesion and its hemodynamic severity using a single imaging technique ( 68 – 70 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging

Ono

Kawashima

Hara

et al. 2020

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been developed and improved as both diagnostic and guidance tools for interventional procedures over the past three decades. IVUS has a resolution of 100 µm with a high tissue penetration and capability of assessing the entire structure of a coronary artery including the external elastic membrane, whereas OCT has a higher resolution of 10-20 µm to assess endoluminal structures with a limited tissue penetration compared to IVUS. Recently, two companies, CONAVI and TERUMO, integrated IVUS and OCT into a single catheter system. With their inherent strength and limitations, the combined IVUS and OCT probes are complementary and work synergistically to enable a comprehensive depiction of coronary artery. In this review, we summarize the performance of the two intracoronary imaging modalities-IVUS and OCT-and discuss the expected potential of the novel hybrid IVUS-OCT catheter system in the clinical field.

show abstract

Section: Potential Clinical Application Of a Hybrid Ivus–oct Cathetermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging

Ono

Kawashima

Hara

et al. 2020

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, in a retrospective study of data collected by more than 50 centers, a weak correlation was reported between vFFR measurement and wire-based FFR measurement because of poor image quality and the difficulty tracking aortic pressure (30). The prognostic value of QFR measurements has been confirmed under various conditions (8,9,31), although the optimal cutoff values for post-PCI QFR measurements have been reported as 0.89, 0.91, and 0.80 in different studies. In the current singlecenter, retrospective study, patients with low post-PCI wirebased FFR (≤0.82) or caFFR (≤0.83) values were associated with a significantly higher risk of VOCE than those with high post-PCI FFR (>0.82) or caFFR (>0.83) values.…”

Section: Discussionmentioning

confidence: 99%

“…Death of unknown etiology was considered cardiovascular death. MI was defined as new Q waves or one plasma level of creatine kinase-myocardial band (CK-MB) ≥ 5 × upper limit of normal (ULN; or troponin ≥ 35 × ULN if CK-MB was not available) in the context of acute coronary syndrome (ACS) (9). TVR was defined as the repeat revascularization or bypass grafting of the target vessel.…”

Section: Follow-up and End Pointsmentioning

confidence: 99%

Agreement of Angiography-Derived and Wire-Based Fractional Flow Reserves in Percutaneous Coronary Intervention

Zheng

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Coronary angiography-derived fractional flow reserve (caFFR) measurements have shown good correlations and agreement with invasive wire-based fractional flow reserve (FFR) measurements. However, few studies have examined the diagnostic performance of caFFR measurements before and after percutaneous coronary intervention (PCI). This study sought to compare the diagnostic performance of caFFR measurements against wire-based FFR measurements in patients before and after PCI.Methods: Patients who underwent FFR-guided PCI were eligible for the acquisition of caFFR measurements. Offline caFFR measurements were performed by blinded hospital operators in a core laboratory. The primary endpoint was the vessel-oriented composite endpoint (VOCE), defined as a composite of vessel-related cardiovascular death, vessel-related myocardial infarction, and target vessel revascularization.Results: A total of 105 pre-PCI caFFR measurements and 65 post-PCI caFFR measurements were compared against available wire-based FFR measurements. A strong linear correlation was found between wire-based FFR and caFFR measurements (r = 0.77; p < 0.001) before PCI, and caFFR measurements also showed a high correlation (r = 0.82; p < 0.001) with wire-based FFR measurements after PCI. A total of 6 VOCEs were observed in 61 patients during follow-up. Post-PCI FFR values (≤0.82) in the target vessel was the strongest predictor of VOCE [hazard ratio (HR): 5.59; 95% confidence interval (CI): 1.12–27.96; p = 0.036). Similarly, patients with low post-PCI caFFR values (≤0.83) showed an 8-fold higher risk of VOCE than those with high post-PCI caFFR values (>0.83; HR: 8.83; 95% CI: 1.46–53.44; p = 0.017).Conclusion: The study showed that the caFFR measurements were well-correlated and in agreement with invasive wire-based FFR measurements before and after PCI. Similar to wire-based FFR measurements, post-PCI caFFR measurements can be used to identify patients with a higher risk for adverse events associated with PCI.

show abstract

“…They are expected to support physicians or operators in decision-making for the indication of revascularization without using a pressure wire. Considering the advantages of less invasiveness and timeeffectiveness, angiography-derived FFR potentially plays a role in specific situations, such as a non-culprit lesion assessment in the setting of acute coronary syndrome, post-PCI lesion assessment, and patient risk assessment using the functional SYNTAX score [74][75][76][77][78].…”

Section: Angiography-derived Ffrmentioning

confidence: 99%

Clinical expert consensus document on quantitative coronary angiography from the Japanese Association of Cardiovascular Intervention and Therapeutics

Suzuki

Asano

Nakazawa

et al. 2020

Cardiovasc Interv and Ther

Self Cite

View full text Add to dashboard Cite

show abstract

Clinical Implication of Quantitative Flow Ratio After Percutaneous Coronary Intervention for 3-Vessel Disease

Cited by 81 publications

References 24 publications

Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging

Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging

Agreement of Angiography-Derived and Wire-Based Fractional Flow Reserves in Percutaneous Coronary Intervention

Clinical expert consensus document on quantitative coronary angiography from the Japanese Association of Cardiovascular Intervention and Therapeutics

Contact Info

Product

Resources

About