Clinical implication of prolonged fever in children with cat scratch disease

Tsujino, Kumiko; Tsukahara, Masato; Tsuneoka, Hidehiro; Ichihara, Kiyoshi; Furuya, Tomoko; Kawauchi, Shigeto; Oga, Atsunori; Sasaki, Kohsuke

doi:10.1007/s10156-004-0320-8

Cited by 26 publications

(16 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, [55] one case of fatal meningitis and encephalitis was reported in a 4-year-old child [89]. An expanding clinical spectrum associated with B. henselae infection: B. henselae has been identified as a frequent cause of prolonged fever and fever of unknown origin in children [114,217,218].…”

Section: Humansmentioning

confidence: 99%

Factors associated with the rapid emergence of zoonotic Bartonella infections

et al. 2005

View full text Add to dashboard Cite

-The present manuscript reviews the factors associated with the emergence of these zoonotic pathogens, including better diagnostic tools and methods to identify these fastidious bacteria, host immunosuppression (caused by infectious agents, cancer, aging or induced by immunosuppressive drugs), the interaction of co-infection by several infectious agents that may enhanced the pathogenecity of these bacteria, increased outdoor activity leading to exposure to wildlife reservoirs or vectors, poverty and low income associated with infestation by various ectoparasites, such as body lice and finally the dispersal of Bartonellae around the world. Furthermore, a description of the main epidemiological and clinical features of zoonotic Bartonellae is given. Finally, the main means for diagnosis, treatment and prevention of these diseases are presented.

show abstract

Section: Humansmentioning

confidence: 99%

Factors associated with the rapid emergence of zoonotic Bartonella infections

et al. 2005

View full text Add to dashboard Cite

show abstract

“…A few reports of CSD without regional lymphadenopathy, but associated with prolonged fever or systemic complications, have been described previously. 6,7 There may be two plausible explanations for the frequent coincidence of lack of lymphadenopathy and the presence of persistent fever or systemic complications. First, a regional lymph node may fail to react properly to the entry of the bacteria, thus allowing rapid systemic infection.…”

mentioning

confidence: 99%

Analysis of data in 30 patients with cat scratch disease without lymphadenopathy

Tsuneoka

Tsukahara

2006

Journal of Infection and Chemotherapy

Self Cite

View full text Add to dashboard Cite

“…Cases of multiple hepatosplenic lesions in Japanese patients with CSD have been reported previously (10). To the best of our knowledge, this is the first reported case of multiple renal and splenic lesions in a Japanese patient with CSD.…”

mentioning

confidence: 65%

Multiple Renal and Splenic Lesions in Cat Scratch Disease

et al. 2016

View full text Add to dashboard Cite

SUMMARY: Cat scratch disease (CSD) is an infectious disease caused by Bartonella henselae. Atypical clinical presentations of CSD include prolonged fever and multiple hepatosplenic lesions. Furthermore, multiple renal lesions are extremely rare in CSD. An 11-year-old Japanese girl presented at our hospital with a prolonged fever of unknown cause after being scratched and bitten by a kitten. Abdominal computed tomography (CT) revealed multiple small, round hypodense lesions in both kidneys and the spleen. Based on her history and the CT results, her diagnosis was CSD. The diagnosis was confirmed by serological tests, which indicated antibodies against B. henselae. After treatment with azithromycin, her fever immediately improved. Careful history taking and imaging are essential for the diagnosis of atypical CSD. In CT images, not only hepatosplenic lesions but also renal lesions are important features indicative of a diagnosis of atypical CSD. Subsequently, a diagnosis of CSD can be confirmed by specific serological tests. This is the first reported Japanese case of multiple renal and splenic lesions in a patient with CSD. Although difficult to diagnose, an early diagnosis atypical CSD and appropriate treatment are important to prevent complications and the need for invasive examinations.Cat scratch disease (CSD), which is generally seen in children, is an infectious disease caused by Bartonella henselae, a gram-negative bacillus (1). Typical CSD is generally benign and self-limiting. CSD is characterized by regional lymphadenopathy with fever following a scratch or bite from a cat or kitten. However, certain CSD cases may present with atypical symptoms. Atypical CSD clinical presentations might include prolonged fever and multiple hepatosplenic lesions (2). On the other hand, multiple renal lesions are extremely rare in CSD (3). Here, we present the case of a child with atypical CSD, who had multiple renal and splenic lesions.A previously healthy 11-year-old Japanese girl presented to our hospital with a fever of unknown cause. Empiric antibiotics (oral clarithromycin 10 mg/kg/day for 9 days, oral minomycin 4 mg/kg/day for 5 days, and intravenous ceftriaxone 75 mg/kg/day for 5 days) were administered before she visited our hospital, but the fever persisted. She had a 1-month history of a persistent fever at night (her temperature rose to 39-409 C at night and dropped to 36-379 C during the daytime) after being scratched and bitten by a kitten.On physical examination, neck lymphadenopathy with minimal pain was observed. Routine laboratory test results, including a complete blood count, hepatic and renal function tests, and urinalysis, were normal; however, she had a high C-reactive protein level (4.57 mg/dL; reference range [rr], ＜0.27 mg/dL) and an increased erythrocyte sedimentation rate (ESR, 74 mm/h; rr, 5-15 mm/h). Serum immunoglobulin (Ig) A and IgM levels were normal; however, she had high IgG (1,921 mg/dL; rr, 870-1,700 mg/dL) and complement (C3, 186 mg/dL; C4, 38 mg/dL; and CH50, 50 U/mL; rr's, 65-135 mg...

show abstract

Clinical implication of prolonged fever in children with cat scratch disease

Cited by 26 publications

References 28 publications

Factors associated with the rapid emergence of zoonotic Bartonella infections

Factors associated with the rapid emergence of zoonotic Bartonella infections

Analysis of data in 30 patients with cat scratch disease without lymphadenopathy

Multiple Renal and Splenic Lesions in Cat Scratch Disease

Contact Info

Product

Resources

About