Clinical implication of plasma level of soluble fibrin monomer-fibrinogen complex in patients with abdominal aortic aneurysm

Abstract

The results indicated that soluble FM-fibrinogen complex appears to be a useful diagnostic molecular marker to assess the activity of the coagulation system, and that its preoperative level may serve as a potential risk factor for intraoperative hemorrhagic diathesis in patients undergoing elective AAA repair.

Factor XIII Deficiency and Thrombocytopenia Are Frequent Modulators of Postoperative Clot Firmness in a Surgical Intensive Care Unit

“…In line, we could later demonstrate that increased preoperative fibrin monomer (FM) concentrations that are associated with increased blood loss are likely secondary to reduced cross-linking capacity due to reduced factor XIII (FXIII) availability per unit of thrombin generated [20][21][22]. The hypothesis that early supplementation of FXIII would benefit such patients when undergoing surgery was later confirmed in a prospective, double-blind, placebo controlled trial [23].…”

Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm

“…[29][30][31] An association between elevated fibrinogen and atherosclerotic peripheral arterial disease has been widely reported, and elevated levels of plasma fibrinogen are found in patients who subsequently develop peripheral arterial disease. 30,[32][33][34] The association between intact AAAs and plasma fibrinogen levels has been extensively investigated 8,[35][36][37][38][39][40][41][42][43][44][45][46][47] (Table I). Seven of 14 studies have reported significantly elevated fibrinogen levels in patients with asymptomatic AAAs.…”

“…57 Thus, PF1 ϩ 2 and TAT are biomarkers of coagulation activation and thrombin generation. This review identified eight studies that reported on the effect of AAAs on the levels of one or both of these biomarkers [41][42][43]45,47,[50][51][52] ( Table II). Elevated levels of both TAT and PF1 ϩ 2 have been demonstrated in men with small AAAs Ͻ55 mm in diameter.…”

Coagulation and Fibrinolysis Markers and Their Use for the Prediction of High Risk Patients with Venous Thromboembolism Following Total Hip Arthroplasty

“…This is why SF is regarded as a very sensitive marker showing a hypercoagulable state when significantly elevated in plasma. The hypercoagulable state is often caused by various invasive procedures, such as surgery, and plasma levels of SF are recognized to rise rapidly during and after surgery [18,19].…”