Clinical implication of human leukocyte antigen (<scp>HLA</scp>)‐<scp>F</scp> expression in breast cancer

Harada, Aya; Ishigami, Sumiya; Kijima, Yuko; Nakajo, Akihiro; Arigami, Takaaki; Kurahara, Hiroshi; Kita, Yoshiaki; Yoshinaka, Heiji

doi:10.1111/pin.12343

Cited by 38 publications

(30 citation statements)

References 25 publications

(58 reference statements)

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“…It is possible that changes in classical HLA-class II molecules and non-classical HLA-class I molecules, which we observed in childhood obesity with and without insulin resistance, can contribute to these numerous intrinsic mechanisms of glucose and lipid metabolism dysregulation as well as cellular growth, because HLA-DR receptor and non-classical HLA-class I molecules play an important role in the regulation of both immune response and proliferative processes and participate in endoplasmic reticulum stress, an important factor of insulin resistance and obesity (Schaiff et al 1992;Minchenko et al 2005;Yuzefovych et al 2013;Han and Kaufman 2014;Lee and Ozcan 2014;Carosella et al 2015;Walentowicz-Sadlecka et al 2018;Yang et al 2018). Furthermore, there is data that both HLA-DR receptor and non-classical HLA-class I molecules play an important role in tumorigenesis (Kochan et al 2013;Morandi et al 2013;Leite et al 2014;Zeestraten et al 2014;Harada et al 2015;Ishigami et al 2015;Brown et al 2016;Martinez-Canales et al 2017;Winkler et al 2017;Walentowicz-Sadlecka et al 2018;Wu et al 2018). It is interesting to note that the absent in melanoma 2 (AIM2), which is a member of the IFN-inducible nuclear proteins, associated with both infection defense and tumor pathology, mediates induction of several interferon-stimulated genes, including genes encoding the major histocompatibility complex class II antigens HLA-DRA and HLA-DRB in cancer cells (Kochan et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, expression of HLA-F is correlated with tumor cell invasion and metastasis (Xu et al 2013;Ishigami et al 2015). HLA-F expression was found to be enhanced in gastric adenocarcinoma, breast cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma, and neuroblastoma (Zhang et al 2013;Morandi et al 2013;Harada et al 2015;Martinez-Canales et al 2017;Wu et al 2018).…”

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confidence: 98%

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Insulin resistance in obese adolescents affects the expression of genes associated with immune response

Minchenko

2019

Endocrine Regulations

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Objective. The development of obesity and its metabolic complications is associated with dysregulation of various intrinsic mechanisms, which control basic metabolic processes through changes in the expression of numerous regulatory genes.Methods. The expression level of HLA-DRA, HLA-DRB1, HLA-G, HLA-F, and NFX1 genes as well as miR-190b was measured in the blood of obese adolescents without signs of resistance to insulin and with insulin resistance in comparison with the group of relative healthy control individuals without signs of obesity.Results. It was shown that obesity without signs of insulin resistance is associated with upregulation of the expression level of HLA-DRA and HLA-DRB1 genes, but with down-regulation of HLA-G gene expression in the blood as compared to control group of relative healthy adolescents. At the same time, no significant changes were observed in the expression level of HLA-F and NFX1 genes in the blood of this group of obese adolescents. Development of insulin resistance in obese individuals leads to significant down-regulation of HLA-DRA, HLA-DRB1, HLA-G, and HLA-F gene expressions as well as to up-regulation of NFX1 gene as well as microRNA miR-190b in the blood as compared to obese patients without signs of insulin resistance.Conclusions. Results of this study provide evidence that obesity affects the expression of the subset of genes related to immune response in the blood and that development of insulin resistance in obese adolescents is associated with strong down-regulation of the expressions of HLA-DRA, HLA-DRB1, HLA-F, and HLA-G genes, which may be contribute to the development of obesity complications. It is possible that transcription factor NFX1 and miR-190b participate in downregulation of HLA-DRA gene expression in the blood of obese adolescents with insulin resistance.

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Section: Discussionmentioning

confidence: 99%

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confidence: 98%

Insulin resistance in obese adolescents affects the expression of genes associated with immune response

Minchenko

2019

Endocrine Regulations

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“…Yet in NSCLC, positive HLA-F expression is not associated with disease progression and differentiation status of the tumor [149]. The occurrence of HLA-F in breast cancer correlates with the size of tumor, but there is no evidence for nodal involvement [152].…”

Section: Hla-f In Tumorsmentioning

confidence: 98%

“…Until now, HLA-F has been detected immunohistochemically in various cancers, i.e. non-small cell lung cancer (NSCLC) [149], esophageal squamous cell carcinoma [150], gastric adenocarcinoma [151] and breast cancer [152].…”

Section: Hla-f In Tumorsmentioning

confidence: 99%

Dynamic Interaction between Immune Escape Mechanism and HLA-Ib Regulation

Hò¹,

Heinen²,

Stieglitz³

et al. 2019

Immunogenetics

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HLA molecules scan the intracellular proteome and present self-or non-selfpeptides to immune effector cells. HLA-Ia (HLA-A, HLA-B and HLA-C) are the most polymorphic genes, resulting in various numbers of allelic variants expressed on the surface of almost all nucleated cells. In contrast to HLA-Ia molecules that activate the immune system during pathogenic invasion, the marginal polymorphic HLA-Ib molecules (HLA-E, HLA-F and HLA-G) are upregulated during pathogenic episodes and mediate immune tolerance. A fine tuning between downregulation of HLA-Ia and upregulation of HLA-Ib can be observed through immunological episodes that require to remain unrecognized by immune effector cells. While HLA-Ia molecules collaborate by presenting a wide range of peptides, every HLA-Ib molecule is highly specialized in its protective immune function and seems to be restricted in the presentation of peptides. Additionally, Ia molecules are expressed ubiquitously while the expression of HLA-Ib molecules is strictly restricted to certain tissues and occurs instantly on demand of the cells/tissue that attempt to be hidden from the immune system. The more knowledge becomes available for the function of HLA-Ib molecules; the question emerges if the molecular typing of HLA-Ib molecules would be reasonable to take a decision post treatment for personalized cellular therapies.

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“…The HLA-F locus has been unraveled in the recent years as an immunomodulatory gene (Goodridge et al 2010). Similar to HLA-G, its expression in the tumor leads to tumor cell escape from the NK cell cytotoxicity and consequently to poor prognosis of the disease (Harada et al 2015;Xu et al 2015). HLA-F may play an important role on the maintenance of immunotolerance in feto-maternal interface, since it is expressed at the extravillous trophoblasts, during the first and second trimesters (Ishitani et al 2003;Shobu et al 2006), but it is absent at the third one (Hackmon et al 2017).…”

Section: Overview On Non-classical Class I (Hla)-fmentioning

confidence: 99%

Co-infecção Plasmodium falciparum e Schistosoma haematobium: papel dos genes HLA não-clássicos de classe I (HLA-G, -E e -F) na suscetibilidade à malária

Sonon¹

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Ó Espírito Santo, Amor que procede do Pai e do Filho, Sabedoria divina e Fonte de todo saber! Iluminai-me nesta fase de minha vida, em que ainda sou um estudante, quando tenho a responsabilidade de prepararme intelectualmente para colocar ao servisse de todo o que tenho o privilégio de estar aprendendo agora. Permita-me Senhor, vencer as dificuldades próprias desta etapa da minha vida, sem brincar com minhas responsabilidades, mas também sem perder o dom de me descontrair e me alegrar, como é próprio do jovem cristão. Ilumina também os meus colegas para que amanhã estejamos todos a serviço da humanidade. Amém. Pe. Luiz Carlos do NascimentoPrayer of a young student Ó Holy Spirit, Love that proceeds from the Father and the Son, divine Wisdom and Source of all knowledge! Enlighten me at this stage of my life, when I am still a student, when I have the responsibility to prepare myself intellectually to put myself in the service of all that I have the privilege of learning now. Allow me, Lord, to overcome the difficulties of this stage of my life, without playing with my responsibilities, but also without losing the gift of relaxing and rejoicing, as is the case of a young Christian. Enlightens also my colleagues so that, tomorrow we will be all in the service of humanity. Amen. Pe. Luiz Carlos do NascimentoSONON, P. Resumo x Resumo SONON, P. Co-infecção Plasmodium falciparum e Schistosoma haematobium: papel dos genes HLA não-clássicos de classe I (HLA-G, -E e -F) na suscetibilidade à malária. 2018. 200f. Tese (Doutorado direito) Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 2018. A malária causada pelo Plasmodium falciparum (P. falciparum) e a bilharzíase urogenital causada pelo Schistosoma haematobium (S. haematobium) constituem duas doenças infecciosas tropicais alarmantes, sendo ambas endêmicas no Benin. Considerandoque a malária (Th1) e a esquistossomose (Th2) apresentem perfis de citocinas divergentes, na presença de co-infecção, o S. haematobium poderia modular as respostas especificamente dirigidas contra o P. falciparum. Uma vez que, os genes que codificam as moléculas nãoclássicas de histocompatibilidade (HLA-G/-E/-F) possuam propriedades imunomoduladoras, pouca atenção tem sido dedicada ao estudo desses genes em populações da África Subsaariana, que são as de maior diversidade genética. O objetivo deste estudo foi avaliar a variabilidade dos genes HLA-G/-E/-F na população Toffin do Benin, e identificar fatores genéticos de suscetibilidade/resistência à malária causada pelo P. falciparum e/ou bilharziose urogenital, usando uma coorte de crianças (de 4 a 8 anos de idade) não aparentadas. Foram avaliados os segmentos codificantes e reguladores, englobando aproximadamente 5.1 kb do HLA-G, 7.7 kb do HLA-E e 6.2 kb do HLA-F, usando sequenciamento da nova geração. As frequências alélicas e haplotípicas do HLA-G/-E/-F, a diversidade genética, a diversidade nucleotídica, o equilíbrio de Hardy-Weinberg (HW) e de Tajima's D foram realizados utilizando o software ARLEQUIN v3.5.2. O...

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Clinical implication of human leukocyte antigen (HLA)‐F expression in breast cancer

Cited by 38 publications

References 25 publications

Insulin resistance in obese adolescents affects the expression of genes associated with immune response

Insulin resistance in obese adolescents affects the expression of genes associated with immune response

Dynamic Interaction between Immune Escape Mechanism and HLA-Ib Regulation

Co-infecção Plasmodium falciparum e Schistosoma haematobium: papel dos genes HLA não-clássicos de classe I (HLA-G, -E e -F) na suscetibilidade à malária

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