Clinical implication and prognostic significance of standardised uptake value of primary non-small cell lung cancer on positron emission tomography: analysis of 176 cases☆

Al-Sarraf, Nael; Gately, Kathy; Lucey, Julie; Aziz, Rashid; Doddakula, Kishore; Wilson, Lorraine; McGovern, Eillish; Young, Vincent

doi:10.1016/j.ejcts.2008.07.023

Cited by 103 publications

(83 citation statements)

References 18 publications

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“…The lower SUVmax of adenocarcinomas is consistent with the results of other studies [1,2]. Tumour subtype is known to reflect the differential avidity of 18FDG uptake by cancer cells [21]. Glucose transporters mediate FDG uptake, and the expression of these proteins has been found to correlate with FDG uptake [22].…”

Section: Discussionsupporting

confidence: 86%

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Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

et al. 2013

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BackgroundPersonalized cancer therapy remains a challenge. In this context, we attempted to identify correlations between tumour angiogenesis, tumour metabolism and tumour cell type. To this aim, we used single=phase multidetector computed tomography (MDCT) and hybrid positron emission tomography-computed tomography (PET/CT) to determine whether net enhancement and standardized uptake value (SUVmax) were correlated with tumour size and cytology in patients affected by non-small cell lung cancer (NSCLC).Material/MethodsOur study included 38 patients (30 men, 8 women, mean age 70) with a NSCLC measuring between 3 cm and 7 cm, using a 16-slice multidetector CT (Brilliance Philips) and with PET-CT (Biograph 16 Siemens Medical Solutions). The following lesion parameters were evaluated: maximum diameter, medium density before contrast injection (CTpre), medium density after contrast injection (CTpost average), density in the most enhanced part of the lesion after contrast (CTpost max), net enhancement, SUVmax, age, and cytology. Correlation coefficient and p-value were computed for each pair of variables. In addition, correlations were computed for each pair of variables, and for all combinations of tumour types. We focused on subsets of data with more than 10 observations, and with correlation r>0.500 and p<0.05.ResultsA weak correlation (r=0.32; p=0.048) was found between SUVmax and tumour size; the correlation was stronger for masses larger than 31 mm (r=0.4515; p=0.0268). No other correlations were found among the variables examined.ConclusionsOur data may have prognostic significance, and could lead to more appropriate surgical treatment and better treatment outcome.

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Section: Discussionsupporting

confidence: 86%

“…Adenocarcinomas were reported to express low levels of Glut-1 [24]. These tumours have a lower 18FDG uptake and a lower SUVmax than squamous cell tumours [21]. However, although Glut-1 is the major glucose transporter expressed in NSCLC, it is neither the sole nor the rate-limiting determinant of FDG uptake [25].…”

Section: Discussionmentioning

confidence: 99%

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

et al. 2013

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“…In the present study, a SUV max cutoff value of 7.5 was selected using the lowest log-rank test P value (supplemental online Figure 2), which was the same procedure reported by other studies [11,14]. When we further analyzed this SUV max cutoff in each primary tumor subtype, this value of 7.5 was also defined in GB Ca and AoV Ca but not ICC (supplemental online Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…Some authors reported that differences in cutoff values of PET SUV max are attributable to different cancer subtypes [11]. Others claim that more analyses with larger numbers of cases or independent studies are needed to determine the most appropriate cutoff point and thereby decrease the risk of falsepositive results [14].…”

Section: Discussionmentioning

confidence: 99%

“…The extent of uptake of 18 F-FDG by a cancer, which usually correlates with the degree of tumor proliferation and metabolism, is evaluated by a semiquantitative measurement, the standardized uptake value (SUV) [10]. The prognostic significance of 18 F-FDG uptake, measured using the maximal standardized uptake value (SUV max ), has been evaluated in lung, endometrial, cervical, and renal cell carcinomas [11][12][13][14][15][16][17][18]. Studies of the clinical significance of metabolic activity in advanced biliary tract cancers are limited.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Characteristics of Advanced Biliary Tract Cancer Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Their Clinical Implications

Cho

Kim

et al. 2015

The Oncologist

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Prognostic impact of the tumor volume doubling time in clinical T1 non‐small cell lung cancer with solid radiological findings

Nakahashi

Shiono

Nakatsuka

et al. 2022

Journal of Surgical Oncology

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Background The purpose of this study was to investigate better radiological prognostic factors in clinical T1 pure‐solid non‐small cell lung cancer (NSCLC). Methods This study enrolled 284 patients with clinical T1 solid NSCLC who underwent anatomical lung resection. The Cox proportional hazard model was used to evaluate the prognostic impact of tumor volume doubling time (VDT) at disease‐free survival (DFS) and cancer‐specific survival (CSS). Results The median VDT was 347 days. Age (hazard ratio (HR) = 1.04; 95% confidence interval (CI), 1.01–1.07) and standardized uptake value max (SUVmax) (>6.0) (HR = 2.61; 95% CI, 1.52–4.66) were identified as significantly independent worse prognostic factors for DFS in a multivariable analysis without VDT. Furthermore, a multivariable analysis without SUVmax identified age (HR = 1.06; 95% CI, 1.03–1.09), CEA (>5.0 ng/ml) (HR = 2.34; 95% CI, 1.30–4.02), tumor diameter on CT (>2.0 cm) (HR = 1.91; 95% CI, 1.18–3.13), and VDT (HR = 4.03; 95% CI, 2.41–6.93) as significantly independent worse prognostic factors for DFS. Conclusions The VDT value could be a useful prognostic factor in clinical T1 solid NSCLC.

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Clinical implication and prognostic significance of standardised uptake value of primary non-small cell lung cancer on positron emission tomography: analysis of 176 cases☆

Cited by 103 publications

References 18 publications

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

Metabolic Characteristics of Advanced Biliary Tract Cancer Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Their Clinical Implications

Prognostic impact of the tumor volume doubling time in clinical T1 non‐small cell lung cancer with solid radiological findings

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