Clinical Implementation of Single-Cell RNA Sequencing Using Liver Fine Needle Aspirate Tissuesampling and Centralized Processing Captures Compartment Specific Immuno-Diversity

Implementation of a controlled human infection model for evaluation of HCV vaccine candidates

“…In addition, the use of elective fine needle aspirates of the liver after exposure should be considered. This low‐risk procedure has now been successfully used for comprehensive transcriptional analysis of all intrahepatic immune cells107 and would be especially valuable where vaccination may lead to a very limited infection with immune changes detectable only in the liver.…”