Clinical Impacts of Cd38+ B-Cells on Acute Cellular Rejection With Cd20+ B-Cells in Renal Allograft

Hwang, Hyung Bin; Song, Ji Hun; Kang, Sung Hak; Chung, Byung Ha; Choi, Byungjoo; Choi, Yeong Jin; Kim, J. I.; Moon, In-Sung; Kim, Y. S.; Kim, S. Y.; Yang, Chul-Woo

doi:10.1097/00007890-201007272-01756

Cited by 7 publications

(11 citation statements)

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“…In other studies, the presence of B cells (CD20) (12,24,28), macrophages (CD68) (20Y23), and cytotoxic T cells (Granzyme B, FasL) (17) was associated with steroid-resistant acute rejection. By univariate analyses, we did find an association between the expression of Granzyme B and macrophage-specific transcripts (mannose receptor and S100 calcium-binding protein A9) and steroid-resistant rejection.…”

Section: Discussionmentioning

confidence: 93%

Quantitative Polymerase Chain Reaction Profiling of Immunomarkers in Rejecting Kidney Allografts for Predicting Response to Steroid Treatment

Rekers

Bajema²,

Mallat³

et al. 2012

Transplantation

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Section: Discussionmentioning

confidence: 93%

Quantitative Polymerase Chain Reaction Profiling of Immunomarkers in Rejecting Kidney Allografts for Predicting Response to Steroid Treatment

Rekers

Bajema²,

Mallat³

et al. 2012

Transplantation

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“…12,16,23,26,27 The plasma cell density is significantly greater and associated with C4d and anti-HLA specific antibodies in patients with progressive functional losses than functionally stable patients. 23 However, the cutoff used in the present study for high intragraft CD138-positive cell density might have been insufficient to detect an association with worse graft outcomes, and it is unclear whether plasma cell infiltration causes injury, irreversible damage, and long-term graft loss.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2014

Exp Clin Transplant

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Objectives: To evaluate B-cell expression patterns and association with function and survival in dysfunctional kidney allografts. Materials and Methods: There were 110 kidney transplant recipients included who had for-cause biopsies. Demographic and transplant data were collected. Immunostaining for B cells, plasma cells, and C4d was performed by the immunoperoxidase technique in paraffin-embedded samples. Circulating antihuman leukocyte antigen donorspecific antibodies were detected in a single-antigen assay at biopsy. The main outcomes were kidney graft survival and function.The patients were evaluated in 3 groups according to the Banff classification: no rejection (40 patients), T-cell-mediated rejection (50 patients), and antibody-mediated rejection (20 patients). Results: The CD138-positive plasma cell-rich infiltrates predominated in antibody-mediated rejection and were associated with stronger reactivity against panel antibodies (r = 0.41; P ≤ .001) and positive donor-specific antibodies (r = 0.32; P ≤ .006). The CD20-positive lymphocytes were associated with T-cell-mediated rejection, increased human leukocyte antigen mismatch, and frequency of retransplant. The CD138-positive cell infiltrates also were significantly greater in patients who had late than early rejection. There was no correlation between cellular CD20 and CD138 expression, and neither CD20 nor CD138 predicted worse graft function or survival. Other markers of antibodymediated rejection such as C4d and donor-specific antibodies were associated with worse graft function and survival at 4 years after transplant. In multivariate analysis, C4d was the only risk factor associated with graft loss. Conclusions: After kidney transplant, CD20-positive B-cell infiltrates were associated with T-cellmediated rejection, and CD138-positive plasma cells were associated with antibody-mediated rejection. Graft loss was associated with the presence of C4d.

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“…33 RTX has also been included in a therapeutic strategy for acute antibody-mediated rejection (AMR) in kidney transplantation 31 because of the prevailing notion that the role of B cells in renal graft survival was mainly limited to Ab production during AMR 34,35 and plasma cell infiltration of the graft correlates with reduced graft survival. 36 However, a randomized controlled trial of 38 patients with acute AMR suggested no additional effect of RTX. 32 The effect of B cell depletion after adoption of RTX is less remarkable in AMR than in ABO blood group-incompatible transplantation.…”

Section: Introductionmentioning

confidence: 99%

Regulatory B cells and advances in transplantation

Luo

Wang

et al. 2018

Journal of Leukocyte Biology

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The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via ligand–receptor interactions and indirectly by secretion of immunosuppressive cytokines, particularly IL‐10. In experimental animal models, the extensively studied IL‐10‐producing B cells have shown unique therapeutic advantages in the transplant field. In addition, adoptive transfer of B cell subsets with regulatory activity may reveal a new approach to prolonging allograft survival. Recent clinical observations on currently available therapies targeting B cells have revealed that Bregs play an important role in immune tolerance and that these cells are expected to become a new target of immunotherapy for transplant‐related diseases.

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Clinical Impacts of Cd38+ B-Cells on Acute Cellular Rejection With Cd20+ B-Cells in Renal Allograft

Cited by 7 publications

References 0 publications

Quantitative Polymerase Chain Reaction Profiling of Immunomarkers in Rejecting Kidney Allografts for Predicting Response to Steroid Treatment

Quantitative Polymerase Chain Reaction Profiling of Immunomarkers in Rejecting Kidney Allografts for Predicting Response to Steroid Treatment

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Regulatory B cells and advances in transplantation

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