Clinical impact of <sup>18</sup>F‐FDG positron emission tomography/CT on adenoid cystic carcinoma of the head and neck

Jung, Ji-hoon; Lee, Sang‐Woo; Son, Seung Hyun; Kim, Choon‐Young; Lee, Changhee; Jeong, Jae‐Uk; Jeong, Shin Young; Ahn, Byeong‐Cheol; Lee, Jaetae

doi:10.1002/hed.24605

Cited by 18 publications

(17 citation statements)

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“…Positron emission tomography with 2-18-fluoro-2deoxy-D-glucose coupled with a CT scan (PET-CT-FDG) plays a major role in the detection and staging of patients with head and neck cancer, but most studies focus on squamous cell carcinoma (SCC) [31]. However, ACC absorbs less FDG than SCC [32].…”

Section: Discussionmentioning

confidence: 99%

Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Atallah

Moya‐Plana

Malard³

et al. 2020

European Journal of Cancer

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Background: Patterns of nodal involvement in adenoid cystic carcinoma (ACC) of the head and neck have not been sufficiently assessed to guide a decision of prophylactic neck dissection (ND). The objective of this study is to analyse the influence of ND on event-free survival (EFS) for patients with cN0 ACC. Patients and methods: A multicentre prospective study was conducted between 2009 and 2018. Patients presenting cN0 non-metastatic ACC on any site, and who received surgery on the tumour, were included. EFS was the main judgement criterion. A comparative survival analysis between the groups that received a ND versus those that did not was performed, using a propensity score. Analyses were carried out using the R software. Results: Between 2009 and 2018, 322 patients with cN0 ACC were included, out of which 58% were female. The average age was 53 years. Tumours were in minor salivary glands in 58% of cases, and 52% had T3/T4 stages.ND was performed on 46% of patients. Out of them, seven had histological lymph node invasion, out of which six had tumour infiltration in the mucosa of oral cavity.After propensity score, the median EFS for N0 patients with ND was 72 months (95% Confidence Interval (CI) [48e81]), compared to 73 months (95% CI [52e85]) for patients without ND (HR Z 1.33; 95% CI [0.82e2.16]; p Z 0.2). Conclusion: ND of cN0 patients does not provide any benefit on EFS, which suggests that its application on such patients is not necessary.

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Section: Discussionmentioning

confidence: 99%

Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Atallah

Moya‐Plana

Malard³

et al. 2020

European Journal of Cancer

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“…Today, 18 F–fluorodeoxyglucose PET/CT (FDG PET/CT) plays a major role in detection and staging of patients with head and neck cancer, with most studies focusing on SCC [ 40 ]. However, it is known that AdCC has different biological characteristics and its FDG-uptake is lower as compared to SCC [ 7 ]. A recent study comparing FDG PET/CT and conventional contrast-enhanced CT in patients with AdCC showed similar sensitivity for primary lesion detection.…”

Section: Discussionmentioning

confidence: 99%

“…However, in two of the 40 patients the primary tumour showed no FDG uptake at all. FDG PET/CT was superior in identification of lymph node and distant metastasis when compared to conventional CT [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Current guidelines consider 18 F–fluorodeoxyglucose PET/CT (FDG PET/CT) at initial presentation to be of additional value to assess disseminated disease of AdCC and therefore to be of influence on treatment planning in these patients [ 6 ]. However, FDG uptake in AdCC is lower than in squamous cell carcinoma (SCC) and not all AdCCs show detectable FDG uptake [ 7 ]. Surgery is the primary treatment option, frequently followed by adjuvant radiation therapy to improve local and regional control [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Prostate-specific membrane antigen PET imaging and immunohistochemistry in adenoid cystic carcinoma-a preliminary analysis

Nulent

Krijger

et al. 2017

Eur J Nucl Med Mol Imaging

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BackgroundAdenoid cystic carcinoma (AdCC) of the head and neck is an uncommon malignant epithelial tumour of the secretory glands. Many patients develop slowly growing local recurrence and/or distant metastasis, for which treatment options are limited. A retrospective analysis of 9 AdCC patients was conducted to analyse the visualization of AdCC on PSMA PET/CT and to investigate the expression of PSMA on primary, recurrent and metastatic AdCC tumour tissue using immunohistochemistry.ResultsLocal recurrence occurred in six patients and eight developed distant metastasis. All PET/CTs depicted PSMA-ligand uptake. Four PSMA PET/CTs showed suspected residual disease, eight scans depicted uptake in areas suspected of distant metastasis. Median Maximum Standardized Uptake Value (SUVmax) in local recurrent and distant metastatic AdCC was 2.52 (IQR 2.41–5.95) and 4.01 (IQR 2.66–8.71), respectively. All primary tumours showed PSMA expression on immunohistochemistry (5–90% expression), as well as all available specimens of local recurrence and distant metastases.ConclusionPSMA PET/CT is able to detect and visualize local recurrent and distant metastatic AdCC. PSMA-specific targeting is supported by PSMA expression on immunohistochemistry.

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“…However, 18 F-FDG-PET-CT cannot safely distinguish malignant processes from benign neoplasms such as Whartin's tumors with high glucose uptake for example [8]. Furthermore, glucose uptake in AdCC is lower than in squamous cell carcinoma (SCC), or may be non-existent [9]. AdCC and SDC often overexpress PSMA (Prostate-specific membrane antigen), indicating a benefit from the use of PSMA PET-CT for these entities [10,11] rather than 11 C-choline PET-CT [10].…”

Section: Diagnostic Imaging For Radiotherapy Planningmentioning

confidence: 99%

Patterns of care analysis for salivary gland cancer: a survey within the German Society of Radiation Oncology (DEGRO) and recommendations for daily practice

et al. 2021

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Background Salivary gland cancer (SGC) is rare and a heterogeneous type of cancer. Prospective randomized trials are lacking. No guideline focusing on standard procedures of radiotherapy (RT) in the treatment of SGC exists. Therefore, we surveyed the members of the German Society of Radiation Oncology (DEGRO) to gain information about current therapeutic strategies of SGC. Methods An anonymous questionnaire was designed and made available on the online platform umfrageonline.com. The corresponding link was sent to all DEGRO members who provided their user data for contact purposes. Alternatively, a PDF printout version was sent. Frequency distributions of responses for each question were calculated. The data were also analyzed by type of institution. Results Sixty-seven responses were received, including answers from 21 university departments, 22 non-university institutions, and 24 radiation oncology practices. Six participants reported that their departments (practice: n = 5, non-university hospital: n = 1) did not treat SGC, and therefore the questionnaire was not completed. Concerning radiation techniques, target volume definition, and concomitant chemotherapy, treatment strategies varied greatly among the participants. Comparing university vs. non-university institutions, university hospitals treat significantly more patients with SGC per year and initiated more molecular pathological diagnostics. Conclusion SGC represents a major challenge for clinicians, as reflected by the inhomogeneous survey results regarding diagnostics, RT approaches, and systemic therapy. Future prospective, multicenter clinical trials are warranted to improve and homogenize treatment of SGC and to individualize treatment according to histologic subtypes and risk factors.

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Clinical impact of ¹⁸F‐FDG positron emission tomography/CT on adenoid cystic carcinoma of the head and neck

Abstract: The F-FDG PET/CT can provide additional information for initial staging, and metabolic PET parameters may serve as prognostic factors of ACCHN. © 2016 Wiley Periodicals, Inc. Head Neck 39: 447-455, 2017.

Cited by 18 publications

References 41 publications

Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Prostate-specific membrane antigen PET imaging and immunohistochemistry in adenoid cystic carcinoma-a preliminary analysis

Patterns of care analysis for salivary gland cancer: a survey within the German Society of Radiation Oncology (DEGRO) and recommendations for daily practice

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Clinical impact of 18F‐FDG positron emission tomography/CT on adenoid cystic carcinoma of the head and neck

Abstract: The F-FDG PET/CT can provide additional information for initial staging, and metabolic PET parameters may serve as prognostic factors of ACCHN. © 2016 Wiley Periodicals, Inc. Head Neck 39: 447-455, 2017.

Cited by 18 publications

References 41 publications

Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Prostate-specific membrane antigen PET imaging and immunohistochemistry in adenoid cystic carcinoma-﻿a preliminary analysis

Patterns of care analysis for salivary gland cancer: a survey within the German Society of Radiation Oncology (DEGRO) and recommendations for daily practice

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Clinical impact of ¹⁸F‐FDG positron emission tomography/CT on adenoid cystic carcinoma of the head and neck

Prostate-specific membrane antigen PET imaging and immunohistochemistry in adenoid cystic carcinoma-a preliminary analysis