Clinical Impact of Staphylococcus aureus Skin and Soft Tissue Infections

Linz, Matthew S.; Mattappallil, Arun; Finkel, Diana; Parker, Dane

doi:10.3390/antibiotics12030557

Cited by 41 publications

(25 citation statements)

References 245 publications

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“…Gut dysbiosis could significantly affect skin homeostasis, influencing the pathogenesis, symptoms, and prognosis of S. aureus infections. As one of the most common bacteria that causes breast infections and mastitis, S. aureus , colonized on the skin, can enter the body through a break in the skin, usually on the nipple [ 46 ]. These bacteria could relocate to the digestive system through the bloodstream and further impact intestinal microbial homeostasis.…”

Section: Staphylococcus Aureus -Caused Skin and Soft-tissue ...mentioning

confidence: 99%

Staphylococcus aureus Infections and Human Intestinal Microbiota

Liu,

Garrett,

Hong

et al. 2024

Pathogens

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Staphylococcus aureus (S. aureus) is a common pathogen that can cause many human diseases, such as skin infection, food poisoning, endocarditis, and sepsis. These diseases can be minor infections or life-threatening, requiring complex medical management resulting in substantial healthcare costs. Meanwhile, as the critically ignored “organ,” the intestinal microbiome greatly impacts physiological health, not only in gastrointestinal diseases but also in disorders beyond the gut. However, the correlation between S. aureus infection and intestinal microbial homeostasis is largely unknown. Here, we summarized the recent progress in understanding S. aureus infections and their interactions with the microbiome in the intestine. These summarizations will help us understand the mechanisms behind these infections and crosstalk and the challenges we are facing now, which could contribute to preventing S. aureus infections, effective treatment investigation, and vaccine development.

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Section: Staphylococcus Aureus -Caused Skin and Soft-tissue ...mentioning

confidence: 99%

Staphylococcus aureus Infections and Human Intestinal Microbiota

Liu,

Garrett,

Hong

et al. 2024

Pathogens

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“…When it comes to staphylococcal infections, the emergence of methicillin-resistant S taphylococcus aureus (MRSA), particularly within the community, is introducing new challenges in the treatment of SSTI. This is underscored by high rates of morbidity, mortality, and recurrence[20,21].…”

Section: Microbiologymentioning

confidence: 99%

Necrotizing fasciitis: an update on epidemiology, diagnostic methods, and treatment

Allaw,

Wehbe,

Kanj

2023

Current Opinion in Infectious Diseases

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Purpose of review The aim of this review is to discuss the latest evidence of epidemiology, diagnostic methods, and treatment of necrotizing soft tissue infections (NSTIs) with a particular focus on necrotizing fasciitis (NF). Recent findings NSTIs have been historically referred to as NF but encompass a broader range of infections, with variable rates ranging from 0.86 to 32.64 per 100 000 person-years, influenced by factors such as climate and seasonal variations. They have diverse microbiological profiles categorized into different types based on the involved pathogens, including polymicrobial or monomicrobial infections caused by organisms such as group A streptococcus (GAS), Staphylococcus aureus, some Gram-negative pathogens, and filamentous fungi following trauma and natural disasters. Diagnosis relies on clinical symptoms and signs, laboratory markers, and imaging. However, the gold standard for diagnosis remains intraoperative tissue culture. Treatment involves repeated surgical debridement of necrotic tissues in addition to intravenous antibiotics. Adjuvant therapies with intravenous immunoglobulin (IVIG) and hyperbaric oxygen therapy (HBOT) might have a role. Soft tissue reconstruction may be necessary following surgery. Summary Prompt diagnosis and proper medical and surgical management of NSTI will improve outcomes.

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“…It exhibited strong antimicrobial activity against all five test cultures. An Aspergillus extract showed remarkably high antimicrobial activity against Staphylococcus aureus, a leading threat of antimicrobial drug resistance as well as a cause of skin infections (16) . Aspergillus has proven to be an endophyte exhibiting a variety of bioactivities in numerous investigations (17,18) .…”

Section: Screening Of Antibacterial Activitymentioning

confidence: 99%

Statistical Optimization for the Production of Antimicrobial Compounds Produced by Mangrove Endophytic Aspergillus sp.

Trivedi¹,

Thumar²

2023

IJST

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Objectives:The purpose of this study was to investigate the antibacterial properties of an endophytic fungus, Aspergillus sp., isolated from the roots of the Avicennia marina belonging to an unexplored location in Kutch, Gujarat, India. The study aimed to optimize various factors to enhance the production of antimicrobial compounds. Methodology: Antimicrobial activity was performed using the agar-well diffusion method, and the results were compared with the standard antibiotic streptomycin as a positive control and DMSO as a negative control. The classical one-factor-at-a-time (OFT) approach was used to optimize various factors such as temperature, pH, culture media, carbon and nitrogen sources, and solvents to enhance antimicrobial production. Response Surface Methodology (RSM) was used to statistically optimize the production of antimicrobial compounds. Findings: The investigation revealed that the endophyte exhibited remarkable inhibitory action against sensitive strains of Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. The most suitable conditions for the production of antimicrobials were; an inoculum size of 1*10 5 in potato dextrose medium at a temperature of 25 • C and pH 6, with an incubation period of 12 days. Starch and ammonium chloride acted as the best carbon and nitrogen sources, respectively. The use of RSM resulted in a 1.46-fold increase in the antimicrobial activity against Pseudomonas sp., with an increase in the zone of inhibition from 18.36mm to 26.8mm. Novelty: The study highlights the unique antimicrobial potential of an unexplored endophyte derived from Avicennia marina roots in Kutch, Gujarat, India. RSM played a crucial role in detecting optimum conditions for the production of antimicrobial compounds, resulting in a significant increase in activity. Its application emphasizes the importance of advanced statistical techniques in improving our understanding of complex biological systems.

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Clinical Impact of Staphylococcus aureus Skin and Soft Tissue Infections

Cited by 41 publications

References 245 publications

Staphylococcus aureus Infections and Human Intestinal Microbiota

Staphylococcus aureus Infections and Human Intestinal Microbiota

Necrotizing fasciitis: an update on epidemiology, diagnostic methods, and treatment

Statistical Optimization for the Production of Antimicrobial Compounds Produced by Mangrove Endophytic Aspergillus sp.

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