Clinical impact of sexual dimorphism in non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH)

Burra, Patrizia; Bizzaro, Debora; Gonta, Anna; Shalaby, Sarah; Gambato, Martina; Morelli, Cristina; Trapani, Silvia; Floreani, Annarosa; Marra, Fabio; Brunetto, M.R.; Taliani, Gloria; Villa, Erica

doi:10.1111/liv.14943

Cited by 61 publications

(40 citation statements)

References 197 publications

(332 reference statements)

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“…Open access in different cohorts. 11 The incidence of MAFLD extent from 19 to 44.5/1000 person-years in Asia, 11 and the prevalence of this condition in China only reaches 29.2%. 12 Moreover, because of the variant obesity rates and the different regional and economic development levels, the prevalence rates are constantly oscillating.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…12 Moreover, because of the variant obesity rates and the different regional and economic development levels, the prevalence rates are constantly oscillating. [11][12][13] In the past 20 years, due to China's rapid economic ascendance, the prevalence of MAFLD in coastal areas has significantly increased with the growth of per capita Gross National Product (GDP). 14 Patients with simple steatosis are prone to develop more severe liver fibrosis and cirrhosis.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

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Gender-specific prevalence of metabolic-associated fatty liver disease among government employees in Tianjin, China: a cross-sectional study

et al. 2021

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ObjectivesTo explore the prevalence and risk factors of metabolic-associated fatty liver disease (MAFLD) in Tianjin government employees of different genders.DesignCross-sectional study.SettingHealth Management Center of Tianjin Union Medical Center.Participants16 924 government employees (59.6% male).MeasuresUltrasound liver examination was performed to determine whether there is fat accumulation in the organ. Participants’ weight and height were measured, and body mass index (BMI) was calculated.ResultsThe overall prevalence of MAFLD in this population was 40.76%. The rates were significantly higher in men (49.42%) than in women (27.97%). The prevalence of MAFLD was highest in men aged 40–49 years (54.04%) and women aged 60–69 years (43.44%). In all BMI groups, the prevalence was higher in men than that in women. In both genders, higher BMI was associated with the risk of MAFLD, especially for BMI ≥31.9 kg/m2.ConclusionsThe prevalence of MAFLD in government employees in Tianjin was significantly higher than the average level in China. The prevalence varied by sex and age group, and those with high BMI were at the highest risk of developing MAFLD.

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Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Gender-specific prevalence of metabolic-associated fatty liver disease among government employees in Tianjin, China: a cross-sectional study

et al. 2021

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“…88,89 Therefore, a large amount of FFAs are delivered and accumulated in hepatocytes, a step that increases the risk for NAFLD development. 90,91 In this scenario, NAFLD prevalence increases in postmenopausal women 56 due to expansion of abdominal adiposity and a higher rate of lipolysis in adipose tissue after oestrogen withdrawal. 92 In addition, the regulation of the expression of proteins involved in hepatic lipid management by oestrogens might represent an additional mechanism.…”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

“…54 Sexual dimorphism of NAFLD development is not a novelty and has been a frequent topic of several reviews. [54][55][56][57] However, due to alterations in body composition, fat distribution, hormonal and metabolic changes, the predisposition to develop NAFLD increases in women after menopause. [58][59][60] To date, there is no effective intervention for NAFLD, 61 including one developed after menopause.…”

Section: Introductionmentioning

confidence: 99%

The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women

Molina-Molina

Furtado

Jones

et al. 2022

Eur J Clin Investigation

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Background The prevalence and severity of nonalcoholic fatty liver disease (NAFLD) increase in women after menopause. This narrative review discusses the causes and consequences of NAFLD in postmenopausal women and describes how physical activity can contribute to its prevention. Methods The authors followed the narrative review method to perform a critical and objective analysis of the current knowledge on the topic. The Medical Subject Heading keywords ‘physical exercise’, ‘menopause’, ‘hormone replacement therapy’, ‘estradiol’ and ‘NAFLD’ were used to establish a conceptual framework. The databases used to collect relevant references included Medline and specialized high‐impact journals. Results Higher visceral adiposity, higher rate of lipolysis in adipose tissue after oestrogen drop and changes in the expression of housekeeping proteins involved in hepatic lipid management are observed in women after menopause, contributing to NAFLD. Excessive liver steatosis leads to hepatic insulin resistance, oxidative stress and inflammation, accelerating NAFLD progression. Physical activity brings beneficial effects against several postmenopausal‐associated complications, including NAFLD progression. Aerobic and resistance exercises partially counteract alterations induced by metabolic syndrome in sedentary postmenopausal women, impacting NAFLD progression and severity. Conclusions With the increased global obesity epidemic in developing countries, NAFLD is becoming a severe problem with increased prevalence in women after menopause. Evidence shows that physical activity may delay NAFLD development and severity in postmenopausal women, although the prescription of age‐appropriate physical activity programmes is advisable to assure the health benefits.

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“…The prevalence of NAFLD differs in gender and age [ 119 ]. Premenopausal women are less likely to develop NAFLD than men of the same age.…”

Section: Transcriptional Regulation Of Lipid Metabolism By Nrs In Nafldmentioning

confidence: 99%

The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD

Hong

Chen

et al. 2021

Oxidative Medicine and Cellular Longevity

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The overproduction of reactive oxygen species (ROS) and consequent oxidative stress contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged that nonalcoholic fatty liver disease (NAFLD) is characterized as a redox-centered disease due to the role of ROS in hepatic metabolism. However, the underlying mechanisms accounting for these alternations are not completely understood. Several nuclear receptors (NRs) are dysregulated in NAFLD, and have a direct influence on the expression of a set of genes relating to the progress of hepatic lipid homeostasis and ROS generation. Meanwhile, the NRs act as redox sensors in response to metabolic stress. Therefore, targeting NRs may represent a promising strategy for improving oxidation damage and treating NAFLD. This review summarizes the link between impaired lipid metabolism and oxidative stress and highlights some NRs involved in regulating oxidant/antioxidant turnover in the context of NAFLD, shedding light on potential therapies based on NR-mediated modulation of ROS generation and lipid accumulation.

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Clinical impact of sexual dimorphism in non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH)

Cited by 61 publications

References 197 publications

Gender-specific prevalence of metabolic-associated fatty liver disease among government employees in Tianjin, China: a cross-sectional study

Gender-specific prevalence of metabolic-associated fatty liver disease among government employees in Tianjin, China: a cross-sectional study

The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women

The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD

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