Clinical impact of sarcopenia and relevance of nutritional intake in patients before and after allogeneic hematopoietic stem cell transplantation

Abstract

Sarcopenia during HSCT was affected by oral caloric intake during the preparation regimen and after transplantation. Physical therapy in conjunction with nutritional therapy may help prevent weakness in HSCT recipients.

Risks of Muscle Atrophy in Patients with Malignant Lymphoma after Autologous Stem Cell Transplantation

“…Similarly, serum albumin levels also decreased significantly in enrolled patients. A decrease in serum albumin level also occurs after ASCT, similar to a previous re- port 27,28) . The serum albumin level is a negative acute-phase protein that decreases in concentration with ongoing systemic inflammation, poor health, and malnutrition.…”

“…Physical inactivity is sufficient to cause prolonged, physical dysfunction, muscle atrophy, and weakness. In addition, muscle atrophy that occurs frequently during ASCT hospitalization has been suggested to be related to nutritional intake 27) . Similarly, serum albumin levels also decreased significantly in enrolled patients.…”

Evaluation of nutritional risk factors in hematopoietic stem cell transplantation-eligible patients

“…(20) High rates of sarcopenia in these patients may reflect hematological disease malignancy and resulting cachexia and muscle wasting. (21) Sarcopenia may be determined by bioimpedance, portable dynamometry (as in this study) and gait speed assessment. These are thought to be highly efficient, reliable and feasible measurements for elderly and adult populations alike.…”

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Adults

“…Tanaka et al, (81) investigated 34 patients with hematological disease undergoing allogeneic HSCT at a hospital, in Japan. The chemotherapy regimen was myeloablative for 14 patients and non-myeloablative for 20.…”