Clinical impact of ki-67 labeling index in non-small cell lung cancer

Jakobsen, Jan Nyrop; Sørensen, Jens Benn

doi:10.1016/j.lungcan.2012.10.008

Cited by 100 publications

(83 citation statements)

References 69 publications

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“…Some studies have revealed that glioma, bladder cancer, and anal cancer with high Ki-67 positivity are more aggressive and invasive [21][22][23]. A metaanalysis reported that the Ki-67 labeling index has prognostic significance in patients with NSCLC and that a high index suggests a poor prognosis [24]. A correlation between cell metabolic activity as determined by 18 F-FDG PET/CT SUV and cell proliferative activity as determined by the Ki-67 expression level has been suggested by some studies on NSCLC [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Park

Lee

Rhee

et al. 2016

Nucl Med Mol Imaging

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Purpose The aim of this study was to evaluate the relationship between semiquantitative parameters on 18 F-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC). Methods Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent 18 F-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on 18 F-FDG PET/ CT images. The protein expression of Ki-67 was examined by immunohistochemical staining. Results Significant correlations were found between the MTVsum and Ki-67 labeling index (r=0.254, p=0.014) and the TLGtotal and Ki-67 labeling index (r=0.239, p=0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r=0.116, p=0.264) and the avgSUVmean and Ki-67 labeling index (r=0.031, p=0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p=0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p= 0.526 and 0.729, respectively). Conclusion In conclusion, the volume-based parameters of 18 F-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by 18 F-FDG PET/CT might be a simple, noninvasive, and useful method to determine the proliferative potential of cancer cells.

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Section: Discussionmentioning

confidence: 99%

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Park

Lee

Rhee

et al. 2016

Nucl Med Mol Imaging

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“…In each case, 1000 cells in 5-7 fi elds of view were analyzed at ×400. Since the distribution of Ki-67 + cells in SCCL was nonparametric, the central trend was presented as the median; it constituted 30% (interquartile interval 23-45%) and was taken as a threshold value, which agreed with the previous fi ndings [7]. Thus, cases with 30% LI Ki-67 were rated as high (+Ki-67) and <30% -as low .…”

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confidence: 74%

“…Immunohistochemical analysis of Ki-67 antigen is a commonly accepted and available method for evaluation of proliferative activity [14]. A correlation of this marker with lung carcinoma prognosis has been demonstrated [3,7].Argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) are universally recognized markers of the cell cycle rate. Two main argyrophilic proteins C23 (nucleolin) and B23 (nucleophosmin) play a key role in the synthesis of ribosomal RNA and constitute up to 75% Ag-NOR proteins [13].…”

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confidence: 99%

Argyrophilic Proteins of Nucleolar Organizer Regions and Proliferative Activity of Cells in Squamous Cell Carcinoma of the Lung

Kobyakov¹,

Климачев

Avdalyan³

et al. 2014

Bull Exp Biol Med

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Argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) and Ki-67 antigen were analyzed in 118 samples of squamous cell carcinoma of the lungs. Tumors with low and high content of Ag-NOR proteins and Ki-67 index were selected. It was found that the content of Ag-NOR proteins correlated with some clinical and morphological parameters (indexes T and N, tumor size less and more that 3 cm, stage of the disease, and tumor differentiation degree) and survival rate. High survival was associated with low content of Ag-NOR proteins and Ki-67 index and low survival correlated with high content of Ag-NOR proteins and Ki-67 index, while intermediate survival was associated with opposite values of Ag-NOR protein content and Ki-67 index. The tumor size, parameter N, and the content of Ag-NOR proteins had independent effects on patient's survival. In patients with squamous cell carcinoma of the lung without metastases in lymph nodes, survival correlated with the content of Ag-NOR proteins; in patients without metastases, survival correlated with tumor size.

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“…Ein bislang in der Routinediagnostik bei NSCLC unzureichend genutzter immunhistochemischer Marker ist der Ki-67-Proliferationsindex. In großen Metaanalysen wird deutlich, dass Ki-67 insbesondere ein prognostisches Potential birgt, wie dies auch für zahlreiche andere Entitäten bekannt ist [4,8]. In unterschiedlichen Kohorten von zusammen etwa 1500 NSCLC konnte belegt werden, dass Ki-67 für ADC jedoch nicht für Plattenepithelkarzinome ein signifikanter prognostischer Parameter ist.…”

Section: Diagnostisch Und Prognostisch Relevante Immunhistochemische unclassified

Diagnose, Prognose und Prädiktion nicht-kleinzelliger Lungenkarzinome

Warth

2015

Pathologe

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Tumor diagnostics are based on histomorphology, immunohistochemistry and molecular pathological analysis of mutations, translocations and amplifications which are of diagnostic, prognostic and/or predictive value. In recent decades only histomorphology was used to classify lung cancer as either small (SCLC) or non-small cell lung cancer (NSCLC), although NSCLC was further subdivided in different entities; however, as no specific therapy options were available classification of specific subtypes was not clinically meaningful. This fundamentally changed with the discovery of specific molecular alterations in adenocarcinoma (ADC), e.g. mutations in KRAS, EGFR and BRAF or translocations of the ALK and ROS1 gene loci, which now form the basis of targeted therapies and have led to a significantly improved patient outcome. The diagnostic, prognostic and predictive value of imaging, morphological, immunohistochemical and molecular characteristics as well as their interaction were systematically assessed in a large cohort with available clinical data including patient survival. Specific and sensitive diagnostic markers and marker panels were defined and diagnostic test algorithms for predictive biomarker assessment were optimized. It was demonstrated that the semi-quantitative assessment of ADC growth patterns is a stage-independent predictor of survival and is reproducibly applicable in the routine setting. Specific histomorphological characteristics correlated with computed tomography (CT) imaging features and thus allowed an improved interdisciplinary classification, especially in the preoperative or palliative setting. Moreover, specific molecular characteristics, for example BRAF mutations and the proliferation index (Ki-67) were identified as clinically relevant prognosticators. Comprehensive clinical, morphological, immunohistochemical and molecular assessment of NSCLCs allow an optimized patient stratification. Respective algorithms now form the backbone of the 2015 lung cancer World Health Organization (WHO) classification.

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Clinical impact of ki-67 labeling index in non-small cell lung cancer

Cited by 100 publications

References 69 publications

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Argyrophilic Proteins of Nucleolar Organizer Regions and Proliferative Activity of Cells in Squamous Cell Carcinoma of the Lung

Diagnose, Prognose und Prädiktion nicht-kleinzelliger Lungenkarzinome

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