Clinical impact of implementation of rapid diagnostic testing of blood cultures with Staphylococcus aureus on patient outcomes

Gritte, Anndee S.; Morneau, Kathleen; Frei, Christopher R.; Cadena-Zuluaga, Jose; Walter, Elizabeth; Hopkins, Teri

doi:10.1016/j.diagmicrobio.2021.115474

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…[112][113][114][115] It can be used on positive blood cultures to shorten time to identification of pathogens and their resistance profiles, and has nonculture-based applications also. 4,116 Results take from around 50 minutes to 2 hours.…”

Section: Culture-based Technologiesmentioning

confidence: 99%

Management of Multidrug-Resistant Infections in Cirrhosis

Gallaher

Shawcross

2022

Semin Liver Dis

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The World Health Organization describes antimicrobial resistance (AMR) as one of the biggest threats to global health, food security, and development with indiscriminate use of antimicrobials globally driving the emergence of multidrug-resistant bacteria, resistant to 60% of antimicrobials in some countries. Infections with multi-drug resistant organisms (MDROs) have increased in recent decades in patients with cirrhosis, who are frequently prescribed antibiotics, regularly undergo invasive procedures such as large volume paracentesis and have recurrent hospitalizations, posing a particular risk in this already immunocompromised cohort of patients. In this review, we explore mechanisms underlying this vulnerability to MDRO infection; the effect of bacterial infections on disease course in cirrhosis; prevalence of MDROs in patients with cirrhosis; outcomes following MDRO infection; fungal infections; antibiotics and their efficacy; and management of MDRO infections in terms of detection, antimicrobial and non-antimicrobial treatments, prophylaxis, antibiotic stewardship, the gut microbiome, and technological interventions.

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Section: Culture-based Technologiesmentioning

confidence: 99%

Management of Multidrug-Resistant Infections in Cirrhosis

Gallaher

Shawcross

2022

Semin Liver Dis

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“…75 Multiple studies have examined the impact of MRSA/SA SSTI kit on the GeneXpert platform, a rapid (1 hour) automated PCR assay on duration of MRSA covering therapy vs traditional culture methods. [51][52][53] These studies all added this intervention to their routine ASP functions and no other interventions were performed at the time. Gritte and colleagues, 52 noted the intervention resulted in a decrease in time to effective therapy, but only a non-statistically significant decrease in vancomycin days (3.0 days vs 1.0 days, P = .323), which maybe at least partially related to the increased MRSA isolated in the post-intervention period.…”

Section: Rapid Testingmentioning

confidence: 99%

“…[51][52][53] These studies all added this intervention to their routine ASP functions and no other interventions were performed at the time. Gritte and colleagues, 52 noted the intervention resulted in a decrease in time to effective therapy, but only a non-statistically significant decrease in vancomycin days (3.0 days vs 1.0 days, P = .323), which maybe at least partially related to the increased MRSA isolated in the post-intervention period. Ben-Zvi study showed a slight decrease in vancomycin exposure as calculated by defined daily doses per 100 patient days.…”

Section: Rapid Testingmentioning

confidence: 99%

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Approaches to Reduce Use and Duration of Anti-MRSA Agents for Antimicrobial Stewardship Programs: A Review of Recent Literature

Wang

Girotto

2022

Journal of Pharmacy Practice

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Antimicrobial stewardship programs (ASPs) have the potential to effectively deescalate unnecessary methicillin-resistant Staphylococcus aureus (MRSA) coverage. This review summarizes literature published from 2014 through 2021 describing contemporary ASP methods and their resulting effectiveness at reducing anti-MRSA agent use (ie vancomycin, linezolid, daptomycin, ceftaroline, and clindamycin). This review of the literature examined the following strategies, which had reports of success in either decreasing the use or duration of anti-MRSA agents: prospective review and feedback, antibiotic timeouts, health system or department protocol changes, polymerase chain reaction (PCR) and rapid testing of patient samples. Most of the current literature continue to support most ASP interventions including antibiotic timeouts, pathways, and molecular testing including MRSA nasal PCRs and rapid diagnostic testing can be successful at reducing unnecessary anti-MRSA use.

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“…For example, there is a great need for biosensors with fast response times to enable rapid tests for medical diagnostics, which increases healthcare access and markedly improves patient outcomes. 1,2 Many sensing modalities have inherently slow response times, often due to poor mass transport limited by diffusion as well as the timescales of adsorption and desorption. 3 Previously reported approaches to reduce response time often focus on novel sensor architecture to diminish the distance required for molecules to diffuse to reach the active element of the sensor, or improve mass transport.…”

Section: Introductionmentioning

confidence: 99%

Reduction in sensor response time using long short-term memory network forecasting

Ward,

Weiss

2023

Applications of Machine Learning 2023

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We report a generalizable computational approach to dramatically reduce biomolecular and chemical sensor response time for applications including medical diagnostics. Comparing the performance of different models, we use experimental data to train ensembles of both traditional recurrent neural networks (RNN) and long short-term memory (LSTM) networks, to accurately predict equilibrium sensor response from data measured over a short time span. This approach is particularly advantageous for sensor platforms with long response times due to poor mass transport, including porous silicon optical biosensors, which we use to validate this methodology through exposure to various concentrations of protein solution and subsequent analysis.

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Clinical impact of implementation of rapid diagnostic testing of blood cultures with Staphylococcus aureus on patient outcomes

Cited by 8 publications

References 10 publications

Management of Multidrug-Resistant Infections in Cirrhosis

Management of Multidrug-Resistant Infections in Cirrhosis

Approaches to Reduce Use and Duration of Anti-MRSA Agents for Antimicrobial Stewardship Programs: A Review of Recent Literature

Reduction in sensor response time using long short-term memory network forecasting

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