Clinical Impact of HTLV-1 Infection in Spain: Implications for Public Health and Mandatory Screening

Toro, Carlos; Rodés, Berta; Aguilera, Antonio; Caballero, Estrella; Benito, Rafael; Tuset, C.; García, Juan González; Lejarazu, Raúl Ortíz de; Eirós, José María; Calderón, E.; Rodrı́guez, Carmen; Soriano, Vincent

doi:10.1097/00126334-200207010-00016

Cited by 16 publications

(7 citation statements)

References 5 publications

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“…These values are clearly lower than the levels obtained for donors in the present study (Korean Red Cross, 2008; Tamim, 2008; Zervou et al, 2004 ). The prevalence of HTLV-I infection among blood donors in non-endemic European countries, such as France (0.004%), Sweden (0.002%), Norway (0.002%), and Spain (0.001%) was significantly lower than the prevalence determined in our study ( Proietti, 2005 ; Toro, 2002 ; Couroucé, 1993 ).…”

Section: Discussioncontrasting

confidence: 87%

“…In the provinces of West Azerbaijan, Ilam, Hormozgan, and Bushehr, the percentages of blood donors with the virus were 0.34, 0.21, 0.18, and 0.01%, respectively ( Abedi, 2009 ; Falahi, 2008 ; Khameneh, 2008 ; Pour Karim, 2004 ). According to recent studies conducted in other countries, the prevalence of HTLV-I infection in blood donors in Japan, Korea, Turkmenistan, Spain, and Brazil was 1.9, 0.007, 0.27, 0.001, and 0.12%, respectively ( Carneiro-Proietti, 2011 ; Chaudhari, 2009 ; Korean red cross, 2008; Toro, 2002 ; Natalia, 1998). The modes of transmission of the virus are mainly through sexual contact with an infected person; mother-to-child, particularly through breastfeeding; and blood transfusion.…”

Section: Introductionmentioning

confidence: 98%

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Seroepidemiology of Human T-Cell Lymphotropic Virus Type-1 (HTLV1) in Mashhad

Safabakhsh¹,

Jalalian²,

Karimi³

2014

GJHS

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Introduction:Human T-cell lymphotropic virus (HTLV-I) is associated with adult T cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The major routes of HTLV-I transmission are mother-to-child, sexual contact, and blood transfusion. Mashhad is one of the main endemic areas in the world for HTLV-I, and minimizing the risk of HTLV-I transmission through blood transfusion is one of the main duties of the Blood Transfusion Center in Mashhad. The aim of this study was to determine the prevalence of HTLV-I in the blood donor population in Mashhad during 2011-2013.Methods:All the blood donors in Mashhad from March 2011 to April 2013 who were diagnosed with HTLV-I on the ELISA screening test and the Western blot confirmatory test were included in this seroepidemiological study.Results:From 174,662 blood donors, 327 donors were confirmed to be infected with HTLV-I according to Western blot assay. The seropositive donors ranged in age from 17 to 59, and their mean age was 39.88±10.49 years. The overall prevalence rates of HTLV-I infection were calculated as 0.18% and 0.19%, respectively.Conclusion:Due to the lower frequency of infection in regular blood donors, younger individuals, and people with higher education levels, the selection of blood donors from these populations should be further considered.

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Section: Discussioncontrasting

confidence: 87%

Section: Introductionmentioning

confidence: 98%

Seroepidemiology of Human T-Cell Lymphotropic Virus Type-1 (HTLV1) in Mashhad

Safabakhsh¹,

Jalalian²,

Karimi³

2014

GJHS

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“…At the present time, 51 cases have been reported in Spain. 16 The large number of infected patients (27 cases) who are native of endemic regions (Africa or South America), is remarkable compared with previous records from 1995. No doubt the inmigratory "boom" of recent years, with people coming from these countries, has contributed to it.…”

mentioning

confidence: 86%

Post-transplantation HTLV-1 myelopathy in three recipients from a single donor

Imirizaldu

Gómez‐Esteban²,

Axpe³

et al. 2003

Journal of Neurology, Neurosurgery & Psychiatry

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Objectives: This paper reports for the first time three cases of infection by HTLV-I via organ transplantation; all the organs coming from the same asymptomatic infected donor. The need is considered for the implementation of compulsory screenings for HTLV antibodies on organ donors and on blood banks. Methods: The determination of antibodies for HTLV-I/II on samples of serum and cerebral spinal fluid from the patients and the donor was performed by enzyme immunoassay and western blot. Analysis of proviral DNA was performed by polymerase chain reaction. To detect changes in the sequence of aminoacids, the tax gene was sequentiated, amplified, and compared with ATK prototype stocks. Spinal cord magnetic resonance imaging, cerebral spinal fluid, and somatosensory evoked potential studies were carried out in all patients. Results: All three transplanted patients developed a myelopathy within a very short period of time. In all three patients and donor the virus belonged to the Cosmopolitan A subtype. The homology of HTLV-I sequences recovered from the patients and donor was 100% in all four cases. Proviral load was high in all three patients. The factors that certainly contributed to the infection in the first place, and the development of the disease later, were on the one hand the high proviral load and their immunosupressed condition, and on the other the virus genotype, which proved to be an aggresive variant. However, the analysis of the histocompatibility antigen showed that two of the patients carried an haplotype that has been associated with a lower risk of developing this disease. Conclusions: It is argued that, although in Spain and other European countries there is not compulsory screening for HTLV antibodies because of the studies that show a low seroprevalence, in view of the cases here reported, and to avoid the serious consequences that such infection has on transplanted patients, compulsory screenings, both on organ donors and on blood banks, should be implemented.

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“…[ 22 23 24 ] The prevalence of infection among donors in France (0.004%), Denmark (0.003%), Sweden (0.002%), Norway (0.002%), Spain (0.001%), and Belgium (0%) was much lower than in our study. [ 25 26 27 28 ]…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of human T-cell lymphotropic virus type-I in blood donors of Northeastern Iran, Sabzevar

Maghsudlu

Safabakhsh

Jamili

2015

Asian J Transfus Sci

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Background and Objectives:Human T-cell lymphotropic virus type-I (HTLV-I) infection is considered as a public health challenge in endemic areas. The virus is associated with severe diseases, such as adult T-cell leukemia/lymphoma, and HTLV-I-associated myelopathy/tropical spastic paraparesis. One of the major routes of the HTLV-I transmission includes blood transfusion. Sabzevar is located in the endemic region of HTLV-I infection. The aim of the present study was to determine the seroprevalence of HTLV-I infection in the blood donors in Sabzevar.Materials and Methods:A total of 35,067 blood donors in Sabzevar from March 2009 to April 2012 who were screened with HTLV-I on the enzyme-linked immunosorbent assay screening test were included in this survey. Reactive samples that confirmed by western blot were considered to be seropositive cases. The required data were obtained from blood donors’ database of blood transfusion service.Results:The overall prevalence of HTLV-1 based on the positive result of western blot test was 0.14%. The seropositive donors aged 17–59 years with a mean age of 38.10 ± 11.82. The prevalence rates of HTLV-I infection in 3 years of study were 0.19%, 0.14%, and 0.09%, respectively. A significant relation between age, sex, educational level, and history of blood donation was observed with seropositivity of HTLV-I.Conclusion:The improvement of donor selection and laboratory screening caused a decline in the prevalence of infection in blood donors. Given the lower prevalence of infection in regular donors with lower age and higher educational level, more efforts should be done to attract blood donors from these populations.

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Clinical Impact of HTLV-1 Infection in Spain: Implications for Public Health and Mandatory Screening

Cited by 16 publications

References 5 publications

Seroepidemiology of Human T-Cell Lymphotropic Virus Type-1 (HTLV1) in Mashhad

Seroepidemiology of Human T-Cell Lymphotropic Virus Type-1 (HTLV1) in Mashhad

Post-transplantation HTLV-1 myelopathy in three recipients from a single donor

Seroepidemiology of human T-cell lymphotropic virus type-I in blood donors of Northeastern Iran, Sabzevar

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