Clinical Impact of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy  Results From Kochi RYOMA Study

Kubo, Toru; Kitaoka, Hiroaki; Okawa, Makoto; Hirota, Takayoshi; Hayato, Kayo; Yamasaki, Naohito; Matsumura, Yuichi; Yabe, Toshikazu; Takata, Jun; Doi, Yoshinori

doi:10.1253/circj.cj-09-0140

Cited by 88 publications

(65 citation statements)

References 25 publications

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“…The Kochi Cardiomyopathy Network, named the Kochi RYOMA study, was established as a community-based and unselected Japanese patient cohort to provide detailed information on the clinical features of HCM and to establish a strategy for better management of this disease. 12 To the best of our knowledge, this is the first report of a prospective multicenter investigation showing the clinical course of HCM in a regional Japanese cohort.…”

Section: Discussionmentioning

confidence: 80%

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Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort　― Results From Kochi RYOMA Study ―

Kubo

Hirota

Baba

et al. 2018

Circ J

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Section: Discussionmentioning

confidence: 80%

“…11 Therefore, in 2004, we established the Kochi Cardiomyopathy Network, named the Kochi RYOMA (registry of myocardial diseases) study, to provide detailed information on the clinical features of HCM in an unselected regional Japanese population. 12 For the present study, we obtained follow-up data in order to assess the…”

mentioning

confidence: 99%

Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort　― Results From Kochi RYOMA Study ―

Kubo

Hirota

Baba

et al. 2018

Circ J

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“…The value of the E/e' ratio has been widely used as an index for evaluating LV end-diastolic pressure or LA pressure in cardiac patients with sinus rhythm. 2,3,15, 16 In patients with AF, however, the measurements of E/e' and TE-e' are often varied because of the lack of atrial contraction and the irregularity of Doppler parameters due to irregular R-R intervals. 11,12,17,18 Therefore, the non-invasive estimation of LV filling pressure has been challenging.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Doppler Tracing of Transmitral Inflow and Mitral Annular Velocity as an Estimate of Elevated Left Ventricular Filling Pressure in Patients With Atrial Fibrillation

Wada

Murata

Tanaka

et al. 2012

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp nalysis of the transmitral inflow (TMF) and of the tissue Doppler imaging (TDI)-derived mitral annular velocities is commonly used for evaluating left ventricular (LV) filling pressure, 1,2 and these measures provide valuable information for the management of patients with heart failure (HF) and sinus rhythm. In particular, the ratio of the early transmitral peak velocity to the early mitral annular velocity (E/e'), which is used for evaluating LV filling pressure, is widely used in the clinical setting. The E/e' range from 8 to 15 is recognized as a gray or indeterminate zone for the estimation of LV filling pressure. 2,3 Furthermore, the measurement of the time interval between the onset of E and the onset of e' (TE-e') has been proposed as another calculation using E and e' that can predict LV filling pressure. 4-9 In addition, the clinical utility of TE-e' in patients with normal systolic function and an indeterminate E/e' has been reported. 10 In contrast, the utilization of TMF and TDI pattern analysis in patients with atrial fibrillation (AF) has not been established because of the lack of atrial contraction and variability of the heart rate. Recently, the usefulness of the simultaneous recording of the ratio of early transmitral peak velocity to flow propagation velocity (E/Vp) and E/e', using a dual Doppler system, for the assessment of LV filling pressure in patients with AF was reported. 11-13 The usefulness of TE-e' obtained by simultaneous recording of the onset of E and e' for the assessment of LV filling pressure in patients with AF, however, was not evaluated.The purpose of the present study was therefore to investigate the following: (1) the usefulness of TE-e' in patients with AF for the assessment of LV filling pressure using the simultaneous recording of TMF and TDI with a dual Doppler system; and (2) the added benefit of using TE-e' to predict LV filling pressure, in addition to the measurement of E/e'. The time interval between the onset of early transmitral flow velocity (E) and that of early diastolic mitral annular velocity (e') (TE-e') is a good predictor of elevated left ventricular (LV) filling pressure in patients with sinus rhythm. Although the evaluation of LV filling pressure using E/e' has been challenging in atrial fibrillation (AF), the usefulness of TE-e' is unknown.

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“…The annual mortality rate in the present study was 1.1%, which is in accordance with previously reported data obtained from community-based cohorts for HCM. 7- 12 The patients were divided into groups according to values of cTnI and BNP. Patients with high cTnI values had significantly more frequent cardiovascular events than did those with low cTnI values, and these adverse events were also observed more frequently in the high BNP group than in the low BNP group (Figures 1A,B).…”

Section: Discussionmentioning

confidence: 99%

Combined Measurements of Cardiac Troponin I and Brain Natriuretic Peptide Are Useful for Predicting Adverse Outcomes in Hypertrophic Cardiomyopathy

Kubo

Kitaoka

Okawa

et al. 2011

Circ J

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Clinical Impact of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy Results From Kochi RYOMA Study

Cited by 88 publications

References 25 publications

Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort　― Results From Kochi RYOMA Study ―

Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort　― Results From Kochi RYOMA Study ―

Simultaneous Doppler Tracing of Transmitral Inflow and Mitral Annular Velocity as an Estimate of Elevated Left Ventricular Filling Pressure in Patients With Atrial Fibrillation

Combined Measurements of Cardiac Troponin I and Brain Natriuretic Peptide Are Useful for Predicting Adverse Outcomes in Hypertrophic Cardiomyopathy

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Clinical Impact of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy Results From Kochi RYOMA Study

Cited by 88 publications

References 25 publications

Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort ― Results From Kochi RYOMA Study ―

Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort ― Results From Kochi RYOMA Study ―

Simultaneous Doppler Tracing of Transmitral Inflow and Mitral Annular Velocity as an Estimate of Elevated Left Ventricular Filling Pressure in Patients With Atrial Fibrillation

Combined Measurements of Cardiac Troponin I and Brain Natriuretic Peptide Are Useful for Predicting Adverse Outcomes in Hypertrophic Cardiomyopathy

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Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort　― Results From Kochi RYOMA Study ―

Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort　― Results From Kochi RYOMA Study ―