Clinical Impact of Aspergillus fumigatus in Children with Cystic Fibrosis

Fainardi, Valentina; Sodini, Chiara; Deolmi, Michela; Ciuni, Andrea; Skenderaj, Kaltra; Stabile, Maria Bice; Neglia, Cosimo; Zani, Elena Mariotti; Spaggiari, Cinzia; Sverzellati, Nicola; Esposito, Susanna; Pisi, Giovanna

doi:10.3390/microorganisms10040739

Cited by 2 publications

(2 citation statements)

References 52 publications

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“…Kraemer et al 13 and Fainardi et al 32 demonstrated that pwCF with ABPA had poorer lung function. In our study, there was no difference between the z-scores of FEV1 and FVC values at the end of the first year among clinical Aspergillus phenotypes, most likely due to the small sample size.…”

Section: Discussionmentioning

confidence: 99%

A case‐control study of the effects of Aspergillus clinical phenotypes on pulmonary functions in patients with cystic fibrosis

Büyükşahin

Doğru

Emiralioğlu

et al. 2023

Pediatric Pulmonology

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Introduction There are no precise data about the effect of Aspergillus infection on lung function other than allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis (pwCF). Here, we aimed to determine clinical phenotypes caused by Aspergillus spp. using laboratory and immunologic parameters and to compare Aspergillus phenotypes in terms of pulmonary function tests (PFT) prospectively. Methods Twenty‐three pwCF who had Aspergillus isolation from respiratory cultures in the last year (case group) and 20 pwCF without Aspergillus isolation in sputum (control group) were included. Aspergillus immunoglobulin (Ig)‐G, Aspergillus IgE, Aspergillus polymerase chain reaction (PCR), galactomannan, total IgE from blood samples, and Aspergillus PCR and galactomannan from sputum, and skin prick test reactivity to Aspergillus antigen were used to distinguish different Aspergillus phenotypes. Pulmonary functions and frequency of pulmonary exacerbations were evaluated during a 1‐year follow‐up. Results Of 23 pwCF, 11 (47.8%) had Aspergillus colonization, nine (39.1%) had Aspergillus bronchitis, and three (13%) had ABPA. Aspergillus infection was not associated with worse z‐scores of forced expiratory volume in the first second (FEV1) (p = 0.612), forced vital capacity (p = 0.939), and the median FEV 1% decline (0.0%/year vs. −4.7%/year, p = 0.626). The frequency of pulmonary exacerbations in the Aspergillus infected and noninfected groups was similar. Conclusion Although Aspergillus spp. Isolation in pwCF was not associated with decreased lung function, a further decline was seen in the ABPA subgroup, and frequent pulmonary exacerbations during the 1‐year follow‐up.

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Section: Discussionmentioning

confidence: 99%

A case‐control study of the effects of Aspergillus clinical phenotypes on pulmonary functions in patients with cystic fibrosis

Büyükşahin

Doğru

Emiralioğlu

et al. 2023

Pediatric Pulmonology

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“…In our study, we found A. fumigatus sensitization in 26.2% of the studied population, which is lower than the prevalence reported in most published studies. 7,8 This variation in prevalence may be attributed to differences in the sensitivity of various diagnostic methods used for identifying Aspergillus spp. sensitization.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Epidemiology and Clinico-Demographic Characteristics of Allergic Bronchopulmonary Aspergillosis in Children with Cystic Fibrosis

Bhat,

Zargar,

Bhat

et al. 2024

J Pediatr Infect Dis

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Objective This study aimed to find the prevalence and clinico-demographic profile of cystic fibrosis (CF) children with allergic bronchopulmonary aspergillosis (ABPA). Methods A cross-sectional study was conducted at a CF clinic of a tertiary care hospital. Participants included the diagnosed cases of children with CF, of both genders, from 4 to 18 years of age. Results A total of 61 patients were enrolled. Sixteen patients (26.2%) had Aspergillus fumigatus sensitization—among these, 10 (16.4%) patients fulfilled the minimum diagnostic criteria for ABPA and 6 (9.8%) had A. fumigatus sensitization only. Two patients were below the age of 5 years, while eight patients were more than 6 years old. The female-to-male ratio was 6:4. High attenuated mucus was the specific finding in our study cohort on computed tomography (CT) chest. All patients with ABPA had significantly higher median (interquartile range [IQR]) levels of total IgE, specific IgE, and IgG for A. fumigatus, and total eosinophil count compared to patients without ABPA. There was also a significant decrease in forced exhalation volume in first second (FEV1) values (6 months apart) in ABPA patients. Conclusion Our study found that ABPA affects 16.4% of our CF population, with 20% of cases occurring in children aged 4 to 5 years. We observed a higher prevalence of ABPA in patients from rural areas. Eosinophilia and serial decline in FEV1 values were observed as potential early markers for ABPA.

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Clinical Impact of Aspergillus fumigatus in Children with Cystic Fibrosis

Cited by 2 publications

References 52 publications

A case‐control study of the effects of Aspergillus clinical phenotypes on pulmonary functions in patients with cystic fibrosis

A case‐control study of the effects of Aspergillus clinical phenotypes on pulmonary functions in patients with cystic fibrosis

Exploring the Epidemiology and Clinico-Demographic Characteristics of Allergic Bronchopulmonary Aspergillosis in Children with Cystic Fibrosis

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