Clinical Impact of Anatomical Liver Resection for Hepatocellular Carcinoma with Pathologically Proven Portal Vein Invasion

Abstract

ALR confers a survival benefit for HCC patients with pPVI.

Correlation between Resection Margin and Disease Recurrence with a Restricted Cubic Spline Model in Patients with Resected Hepatocellular Carcinoma

“…Patients with a pathologic finding of microscopic remnant tumor ( n = 20) or major vascular invasion ( n = 57) were excluded from the present analyses because these factors increase the risk of recurrence in resected HCC [9, 10]. Finally, 419 patients were included in the present study (Fig.…”

Anatomical versus non-anatomical liver resection for hepatocellular carcinoma exceeding Milan criteria

“…Resection methods and extent of liver resection should be planned individually after full consideration of tumour burden and liver function, aiming to achieve curative resection as well as to preserve future liver remnant as much as possible in patients with intermediate or advanced HCC and underlying cirrhosis. For patients with ipsilateral satellite nodules or macroscopic PVTT, AR is preferable and more likely to achieve an R0 resection in those with good liver function reserves. However, the survival data in the matched cohort indicated that, for diverse tumour burdens, the outcomes of AR and NAR were equivalent for patients with similar tumour burdens.…”

The preoperative globulin‐to‐albumin ratio, a novel inflammation‐based prognostic system, predicts survival after potentially curative liver resection for patients with hepatocellular carcinoma

“…Because the indication for anatomical resection at our department is based on the ICGR15, decreased liver function would have been associated with the lower proportion of anatomical resection procedures in the high GAR group. Anatomical resection is closely related to HCC recurrence and prognosis after surgery, because both HCC progression and invasion extend along the portal vein . Therefore, the low rate of anatomical resection would have been associated with poor prognosis after potentially curative LR in the high GAR group.…”

“…,23 decreased liver function would have been associated with the lower proportion of anatomical resection procedures in the high GAR group. Anatomical resection is closely related to HCC recurrence and prognosis after surgery, because both HCC progression and invasion extend along the portal vein 40. Therefore, the low rate of anatomical resection would have been associated with poor prognosis after potentially curative LR in the high GAR group.With regard to operative characteristics, high GAR group had significantly higher operative blood loss and higher rate of red blood transfusion than those of low GAR group.…”