Clinical Impact and Burden of CMV Infection on the Use of Resources in Allogeneic Hematopoietic Cell Transplantation

Abstract

1, 10 on control). All patients were transplanted in the outpatient setting and were admitted for management of sepsis. The endpoints assessed were length of stay from initial admission, readmission rate and length of hospital stay post readmission. Results: Twenty autologous and allogeneic HCT recipients were included after a MRD (n = 5), MUD (n = 3) Haploidenitcal (n = 8), and autologous (n = 4) transplant. Median time from transplant to sepsis diagnosis was 41 days in the control group, and 20 days in the SEP-1 group. For patients treated on the SEP-1 3-hour bundle, the median length of initial hospital stay was 8 days, readmission rates were 20%, and the length of hospital stay for readmission was 4.5 days. Implementing SEP-1 3-hour bundle showed a decline in initial hospital stay by 34% (4.1 days), readmission rates by 33%, and readmission length of stays by 40% (2 days). Recollection time of repeat lactate samples after initial elevation improved to 2.8 hours in the post-implementation group, compared to 9.8 hours in the control group. Conclusion: Declines in readmission rates and length of stays decrease financial burdens placed on admitting facilities, patients, and insurance companies for sepsis-associated costs. It also decreases patients' risk of exposure to hospitalassociated infections. The findings in this pilot study will be further assessed in a larger cohort of prospective patients being treated using the SEP-1 bundle at our program.

The indirect effects of CMV reactivation on patients following allogeneic hematopoietic stem cell transplantation: an evidence mapping

“…3 ). Three studies [ 17 , 29 , 33 ] support that CMV reactivation increases the risk of re-hospitalization, but two studies [ 25 , 36 ] found no association between CMV reactivation and re-hospitalization (Table 4 , Fig. 3 ).…”