Clinical, Imaging, and Pathologic Features of Conditions with Combined Esophageal and Cutaneous Manifestations

Lee, Mathew; Lubner, Meghan G.; Peebles, J. Klint; Hinshaw, Molly; Menias, Christine O.; Levine, Marc S.; Pickhardt, Perry J.

doi:10.1148/rg.2019190052

Cited by 11 publications

(4 citation statements)

References 80 publications

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“…The endoscopic appearance of the gastric mucosa is mainly oval hemispherical or bulbous, with a wide base in most cases and a smooth mucosal bulge with clear demarcation from the surrounding area. However, the endoscopic presentation of GIST is not very specific; therefore, it is difficult to distinguish GIST from other tumours by the microscopic features alone, and there are limitations of endoscopy for exophytic GIST because the lesions are often located in the submucosa, so it is difficult to obtain biopsies [ 11 ]. Ultrasound endoscopy can better compensate for the shortcomings of ordinary endoscopy, with the advantage of being able to distinguish between various layers of the gastric wall, as well as determine the origin of the mass lesion, that is, the specific layer and specific tissue structure of the gastric wall from which it originates and detect exophytic GIST, which is difficult to detect by ordinary endoscopy.…”

Section: Related Workmentioning

confidence: 99%

Analysis of the Diagnostic Effect of EUS-RTE on Giant Cystic Tumours of the Oesophagus Based on Cluster Analysis

Yang

Zhang

et al. 2021

Journal of Healthcare Engineering

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This paper presents an in-depth analysis and study of the diagnostic effectiveness of EUS-RTE in giant cystic tumours of the oesophagus utilizing cluster analysis. A new form of interval data expression was designed based on the cluster analysis algorithm, as well as a new way of updating the cluster radius and cluster centre. Feature triads are defined, eliminating the need to access all historical data at the time of update. It also prevents the case of overfusion of clusters and outputting only one cluster. If there exist a very low number of clusters, the newly merged clusters are reclustered according to the density clustering method for the internal data objects based on the cluster segmentation so that the data objects in the same cluster have a high similarity as possible. All accumulated electronic files of oesophageal cancer cases were collected and comprehensively organized, and all clinical data of 129 eligible cases with a total of 356 consultations were screened in strict accordance with inclusion and exclusion criteria. A database of oesophageal cancer cases was established using Visual FoxPro software, and frequency distribution, cluster analysis, association rule, and chi-square test were used to focus on mining the association between symptoms, disease mechanisms, prescriptions, and medications. The results were analysed and summarized. Overall, the therapeutic efficacy and safety of the three groups of treatment modalities for gastric mesenchymal tumours were positive, and the preoperative endoscopic treatment modalities should be selected based on the EUS-RTE characteristics of the tumour, the site, and the operator’s skill level in a comprehensive manner.

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Section: Related Workmentioning

confidence: 99%

Analysis of the Diagnostic Effect of EUS-RTE on Giant Cystic Tumours of the Oesophagus Based on Cluster Analysis

Yang

Zhang

et al. 2021

Journal of Healthcare Engineering

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“…3 To date, many drugs such as antibiotics like doxycycline and tetracycline, nonsteroidal anti-inflammatory drugs like ibuprofen, aspirin and naproxen, oral bisphosphonates like alendronate, and drugs like ascorbic acid, phenytoin, quinidine, rifampin, warfarin, and many more have been identified as a cause of PIE (Pill-induced esophagitis). [3][4][5][6] Elderly individuals are more prone to develop pill-induced esophagitis due to higher prevalence of esophageal motility disorders, reduction in salivation, and frequent use of high-risk drugs. According to previous reports, women are more likely than men to develop pill-induced esophagitis.…”

Section: Introductionmentioning

confidence: 99%

Clinical and endoscopic features of pill-induced esophagitis

Patel

Panchal

Patel³

et al. 2022

Int J Basic Clin Pharmacol

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Background: Medication can cause an injury in the esophagus by local and systemic effect, leading to esophagitis. Many such medications have been identified as a cause of pill-induced esophagitis. This study was performed to evaluate the clinical and endoscopic findings of pill-induced esophagitis.Methods: This was retrospective observational study, conducted among patients diagnosed endoscopically with pill-induced esophagitis at Ansh gastroenterology clinic, Ahmedabad, India, from April 2017 to March 2021. The data of these patients were recorded in pre-designed case record form by evaluating their past medical records.Results: Total 90 patients were diagnosed with pill-induced esophagitis. Retrosternal chest pain (68.9%), odynophagia (41.1%), dysphagia (25.6%), and epigastric pain (14.4%) were common clinical findings. The major culprit medications were antibiotics, and NSAIDs (non-steroidal anti-inflammatory drugs). Common esophageal endoscopic findings were ulcer (84.4%), erosion (17.8%), and active ulcer bleeding (12.2%). Kissing ulcers were observed in the majority (46.7%) of cases. The majority of ulcer and erosion were located in middle third of the esophagus. All the patients were recovered within 6 to 10 days after treatment with PPIs (proton pump inhibitors) and/or antacids, and withdrawal of the causative medication.Conclusions: Pill-induced esophagitis commonly manifests as retrosternal chest pain, odynophagia and dysphagia, and endoscopy reveals kissing ulcer and erosion in the majority of cases. The condition can be treated with PPIs and/or antacids, and withdrawal of the offending medication.

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“…Multiple prophylactic treatment modalities are available for including first-line therapy with topical corticosteroids, oral antibiotics, and phototherapy. More aggressive treatment with immunomodulatory agents like methotrexate is reserved for severe refractory cases [ 18 ]. In our case, the patient is in remission and actively being treated with topical and oral immunosuppressive therapy as discussed in the case presentation.…”

Section: Discussionmentioning

confidence: 99%

Pityriasis Lichenoides Chronica of Esophagus: A Rare Case Report

Tahir¹,

Elkadi²,

Liu³

et al. 2022

Cureus

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Pityriasis lichenoides chronica (PLC) is an uncommon inflammatory skin condition of unknown cause that ranges from a mild chronic form to a more severe acute eruption. Both forms usually involve the skin of the trunk and proximal extremities, and visceral involvement is not a well-described phenomenon.Here, we report a case of PLC that presented with esophageal involvement that occurred after a period of discontinuation of PLC treatment. The histological pattern of involvement is in the form of lymphocytic esophagitis, a non-specific pattern with a broad differential diagnosis. Awareness of the potential involvement of the esophagus and attention to certain endoscopic and morphological details may better help classify esophagitis biopsies and the diagnosis of this rare non-neoplastic chronic inflammatory disease. To our knowledge, this is the first-ever case of PLC with esophageal involvement, and nothing has been reported in the English literature earlier.

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Clinical, Imaging, and Pathologic Features of Conditions with Combined Esophageal and Cutaneous Manifestations

Cited by 11 publications

References 80 publications

Analysis of the Diagnostic Effect of EUS-RTE on Giant Cystic Tumours of the Oesophagus Based on Cluster Analysis

Analysis of the Diagnostic Effect of EUS-RTE on Giant Cystic Tumours of the Oesophagus Based on Cluster Analysis

Clinical and endoscopic features of pill-induced esophagitis

Pityriasis Lichenoides Chronica of Esophagus: A Rare Case Report

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