Clinical, histopathological, dermatoscopic and digital microscopic features of dermatofibroma: a retrospective analysis of 200 lesions

Şenel, Engin; Karabulut, Yasemin Yuyucu; Şenel, Seher Doğruer

doi:10.1111/jdv.13092

Cited by 26 publications

(30 citation statements)

References 20 publications

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“…Occasionally, dermatofibroma can also simulate normal skin on histology and may be positive for CD163. However, the histiocytic cells in dermatofibroma are larger with more abundant cytoplasm in comparison to the interstitial variant of GA where the mononuclear cells are small . In addition, dermatofibroma will be also positive for FXIIIa, which was negative in the small mononuclear cells in all of our cases of interstitial GA .…”

Section: Discussionmentioning

confidence: 56%

The interstitial variant of granuloma annulare: Clinicopathologic study of 69 cases with a comparison with conventional granuloma annulare

2019

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Background: The full-blown lesion of granuloma annulare (GA) is characterized by necrobiotic granulomas with palisading of histiocytes and stromal mucin deposition. Cases in which the granulomatous features are not fully developed have been described as the "interstitial" variant; however, there is no good definition regarding their criteria for diagnosis. Methods:We conducted a retrospective study of 97 cases of GA.Results: Cases of interstitial GA (69) were paucicellular with scant to no mucin, with only a few scattered mononuclear cells but lacking well-formed granulomas with multinucleated giant cells.Immunohistochemical study showed that the cells in conventional cases of GA stained strongly positive for CD68 and CD163, whereas the small mononuclear cells in interstitial GA were strongly positive only for CD163.Conclusions: Interstitial GA differs from the classical GA in several respects, including morphology and immunophenotype. Use of antibodies to CD163 may be helpful for distinguishing the interstitial variant from other conditions. Recognition of the interstitial variant is of importance to explain the presence of lesions that clinically are suspicious for GA but histologically do not resemble the conventional form of the disease. K E Y W O R D SCD163, dermatopathology, granuloma annulare, immunohistochemistry stains, interstitial granuloma annulare

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Section: Discussionmentioning

confidence: 56%

The interstitial variant of granuloma annulare: Clinicopathologic study of 69 cases with a comparison with conventional granuloma annulare

2019

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“…Dermatoscopically we found that the most prevalent dermatoscopic feature was vascular structures (65%), followed by peripheral pigment network, contrasting with the general literature review which defines the most predominant finding as pigment network (Table ) . We attribute this to our dermatoscopic evaluation with polarized non‐contact dermatoscopy (PNCD), thus avoiding vascular compression and providing optimum imaging of the vascular structures.…”

Section: Discussionmentioning

confidence: 67%

“…Several types of DF have been identified dermatopathologically and with dermatoscopic correlation, the dermatopathology has been predictable in limited studies so far with some conclusions being drawn about the dermatopathological characteristics of DF from dermatoscopic clues.…”

Section: Introductionmentioning

confidence: 99%

Dermatopathological characteristics of dermatofibromas from dermatoscopic clues

et al. 2019

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Background Several types of dermatofibroma (DF) have been identified dermatopathologically and with dermatoscopic correlation, the dermatopathology has been predictable in limited studies so far. We identify DFs with specific dermatoscopic structures and determine the respective dermatopathological correlates. Methods Dermatoscopic and dermatopathologic correlation of 403 DFs were assessed. A pattern analysis algorithm was used for the dermatoscopic evaluation, each lesion being evaluated according to 10 dermatoscopic patterns with further subdivision of the atypical subtype according and their dermatoscopic similarities to other defined skin lesions. Results Dermatoscopic pattern analysis showed typical patterns in 83.4% of DFs with atypical patterns in 16.6%. We classified the atypical DFs according to their dermatoscopic similarity to certain lesions: Melanoma‐like 2.7%, basal cell carcinoma‐like 0.7%, keratoacanthoma‐like 0.5%, seborrheic keratosis‐like 2.7%; nevus‐like 1.5%; nevus sebaceous‐like 0.9%; xanthogranuloma‐like 0.5%; pyogenic granuloma‐like 0.5%; and spitzoid 6.5%. Dermatopathologically 12 subtypes of DFs were identified. It was found that the most common pattern found in fibrocollagenous DFs was the typical pattern with peripheral reticular lines and central white structureless area (32.9%) whereas non‐fibrocollagenous types were more likely to have atypical patterns (65.1%). Conclusions Our study resulted in new conclusions while supporting some previous findings. The fact that the pathogenesis of DF involves a reactive inflammatory process with fibrosis is likely to have diverse effects on dermatoscopic morphology. If atypical dermatoscopic patterns are identified in suspected DF, excisional biopsy may be prudent.

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“…Dermoscopy may enable differentiation of cellular neurothekeoma from other benign tumours such as dermatofibroma and neurofibroma. Dermoscopic patterns of typical dermatofibroma feature peripheral pigment network and a central, white scar‐like patch . The patterns of neurofibroma show peripheral pigmented network, peripheral halo of brown pigmentation and both pink‐red structureless and scar‐like areas .…”

Section: Discussionmentioning

confidence: 99%

“…Dermoscopic patterns of typical dermatofibroma feature peripheral pigment network and a central, white scar-like patch. 9 The patterns of neurofibroma show peripheral pigmented network, peripheral halo of brown pigmentation and both pink-red structureless and scar-like areas. 10 Although they sometimes demonstrate vascular patterns, arborising vessels are rare in both tumours.…”

Section: Discussionmentioning

confidence: 99%

Dermoscopy of multiple cellular neurothekeoma: An analysis of 11 neurothekeomas in a middle‐aged woman

et al. 2019

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Clinical, histopathological, dermatoscopic and digital microscopic features of dermatofibroma: a retrospective analysis of 200 lesions

Abstract: Background Dermatology literature lacks a study investigating both histopathological and dermatoscopic features of

Cited by 26 publications

References 20 publications

The interstitial variant of granuloma annulare: Clinicopathologic study of 69 cases with a comparison with conventional granuloma annulare

The interstitial variant of granuloma annulare: Clinicopathologic study of 69 cases with a comparison with conventional granuloma annulare

Dermatopathological characteristics of dermatofibromas from dermatoscopic clues

Dermoscopy of multiple cellular neurothekeoma: An analysis of 11 neurothekeomas in a middle‐aged woman

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