Clinical, histopathological and immunohistochemical evaluation of daylight photodynamic therapy in the treatment of field cancerization: a study of 30 cases

Abdalla, Beatrice Martinez Zugaib; Pedreiro, Bruna Simas; Morales, Andrezza Garcia; Krutman-Zveibil, Deborah; Paschoal, Francisco Macedo

doi:10.1080/09546634.2020.1789042

Cited by 1 publication

(1 citation statement)

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“…Brain aging is a complex and multifactorial physiological process, induced by genetic, epigenetic, and environmental factors, which could affect neurons and cause mammals to develop behavioral disorders, dementia, and impaired immune response over time ( Costantini et al, 2018 ; Abdalla et al, 2022 ). In this line, previous studies in the same breed of cattle performed by Paciello and colleagues showed that, in line with other animal species, aged bovine showed a build-up of lipofuscin and a progressive reduction of autophagy initiation, as APP protein levels were higher in both hippocampus and dentate gyrus of old animals, associated with lower levels of Beclin-1 and higher expression of LC3 when compared to the young control brain samples ( De Biase et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Proteomic signature profiling in the cortex of dairy cattle unravels the physiology of brain aging

Cozzolino,

Canè,

Gatto

et al. 2023

Front. Aging Neurosci.

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IntroductionAging is a physiological process occurring in all living organisms. It is characterized by a progressive deterioration of the physiological and cognitive functions of the organism, accompanied by a gradual impairment of mechanisms involved in the regulation of tissue and organ homeostasis, thus exacerbating the risk of developing pathologies, including cancer and neurodegenerative disorders.MethodsIn the present work, for the first time, the influence of aging has been investigated in the brain cortex of the Podolica cattle breed, through LC–MS/MS-based differential proteomics and the bioinformatic analysis approach (data are available via ProteomeXchange with identifier PXD044108), with the aim of identifying potential aging or longevity markers, also associated with a specific lifestyle.Results and discussionWe found a significant down-regulation of proteins involved in cellular respiration, dendric spine development, synaptic vesicle transport, and myelination. On the other hand, together with a reduction of the neurofilament light chain, we observed an up-regulation of both GFAP and vimentin in the aged samples. In conclusion, our data pave the way for a better understanding of molecular mechanisms underlying brain aging in grazing cattle, which could allow strategies to be developed that are aimed at improving animal welfare and husbandry practices of dairy cattle from intensive livestock.

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Section: Discussionmentioning

confidence: 99%