Clinical, histological, and immunohistochemical evaluation of facial skin remodeling induced by mesotherapy

Background: Intradermotherapy is considered a minimally invasive procedure, which works through applications of diluted pharmacological drugs, resulting in facial rejuvenation. Methods: 18 women were divided equally into two groups and evaluated before and after treatment (at 45 and 90 days). Four applications were made to the facial region at 15-day intervals; for group 1, traditional injections were given to introduce the anti-ageing substance, and, for group 2, a placebo intervention (0.9% saline application) was given. Results: In the analysis of the group 1 photos, greater filling of the nasogenian groove was observed after two sessions, and the presence of less deep wrinkles in the perioral area was also observed after four treatment sessions. Subjects in both groups complained of pain during the application, even with the use of anaesthetic. Most of the volunteers in group 1 said that the texture of the skin seemed much firmer and classified the therapy as an ‘excellent treatment’. Conclusion: Intradermotherapy shows favourable results in the treatment of facial rejuvenation in women, which is more evident 90 days after the initial application.

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Clinical, histological, and immunohistochemical evaluation of facial skin remodeling induced by mesotherapy

Cited by 2 publications

References 17 publications

Beneficial Effect of Amniotic Membrane Stem Cell and Vitamin C after Fractional Carbon-Dioxide Laser for Photoaging Treatment in Asian Skin

Beneficial Effect of Amniotic Membrane Stem Cell and Vitamin C after Fractional Carbon-Dioxide Laser for Photoaging Treatment in Asian Skin

A study of intradermotherapy with needles in facial rejuvenation

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