Clinical Heinz Body Anemia in a Cat After Repeat Propofol Administration Case Report

Baetge, C; Smith, Lauren C.; Azevedo, Carolina P.

doi:10.3389/fvets.2020.591556

Cited by 11 publications

(14 citation statements)

References 6 publications

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“…Heinz body formation occurs as a result of oxidative damage to hemoglobin and can result in hemolysis [74]. In cats, increased Heinz body formation has previously been shown to be associated with the administration of certain drugs and components, such as propofol [75], acetaminophen [76], or propylene glycol [77]. Therefore, it seems possible that there is an association between the repeated administration of Xraphconn ® and Heinz body formation in this cat.…”

Section: Discussionmentioning

confidence: 84%

Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524

Krentz¹,

Zenger²,

Alberer³

et al. 2021

Viruses

107

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Feline infectious peritonitis (FIP) caused by feline coronavirus (FCoV) is a common dis-ease in cats, fatal if untreated, and no effective treatment is currently legally available. The aim of this study was to evaluate efficacy and toxicity of the multi-component drug Xraphconn® in vitro and as oral treatment in cats with spontaneous FIP by examining survival rate, development of clinical and laboratory parameters, viral loads, anti-FCoV antibodies, and adverse effects. Mass spectrometry and nuclear magnetic resonance identified GS-441524 as an active component of Xraphconn®. Eighteen cats with FIP were prospectively followed up while being treated orally for 84 days. Values of key parameters on each examination day were compared to values before treatment initiation using linear mixed-effect models. Xraphconn® displayed high virucidal activity in cell culture. All cats recovered with dramatic improvement of clinical and laboratory parameters and massive reduction in viral loads within the first few days of treatment without serious adverse effects. Oral treatment with Xraphconn® containing GS-441524 was highly effective for FIP without causing serious adverse effects. This drug is an excellent option for the oral treatment of FIP and should be trialed as potential effective treatment option for other severe coronavirus-associated diseases across species.

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Section: Discussionmentioning

confidence: 84%

Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524

Krentz¹,

Zenger²,

Alberer³

et al. 2021

Viruses

107

View full text Add to dashboard Cite

show abstract

“…Most of these studies have reported that the anemia is not clinically relevant. However, in 2 studies, signs were clinically relevant 159,160 . In 1 study, malaise, anorexia, diarrhea, facial edema, and increased recovery time also were reported 159 .…”

Section: Third‐line Treatmentmentioning

confidence: 97%

“…However, in 2 studies, signs were clinically relevant. 159,160 In 1 study, malaise, anorexia, diarrhea, facial edema, and increased recovery time also were reported. 159 Based on these studies in cats, the total accumulated dose as well as the duration of propofol administration may be important factors for propofol-related adverse effects.…”

Section: Rationalementioning

confidence: 98%

“…However, in a study of cats, no significant differences were detected between animals receiving several propofol boluses at a dose of up to 24 mg/kg with or without 2% benzyl alcohol 158 . Propofol IV CRI or multiple boluses in cats can cause adverse effects such as Heinz body anemia 159‐162 . Most of these studies have reported that the anemia is not clinically relevant.…”

Section: Third‐line Treatmentmentioning

confidence: 99%

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ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats

Charalambous,

Muñana,

Patterson

et al. 2023

Veterinary Internal Medicne

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BackgroundSeizure emergencies (ie, status epilepticus [SE] and cluster seizures [CS]), are common challenging disorders with complex pathophysiology, rapidly progressive drug‐resistant and self‐sustaining character, and high morbidity and mortality. Current treatment approaches are characterized by considerable variations, but official guidelines are lacking.ObjectivesTo establish evidence‐based guidelines and an agreement among board‐certified specialists for the appropriate management of SE and CS in dogs and cats.AnimalsNone.Materials and MethodsA panel of 5 specialists was formed to assess and summarize evidence in the peer‐reviewed literature with the aim to establish consensus clinical recommendations. Evidence from veterinary pharmacokinetic studies, basic research, and human medicine also was used to support the panel's recommendations, especially for the interventions where veterinary clinical evidence was lacking.ResultsThe majority of the evidence was on the first‐line management (ie, benzodiazepines and their various administration routes) in both species. Overall, there was less evidence available on the management of emergency seizure disorders in cats in contrast to dogs. Most recommendations made by the panel were supported by a combination of a moderate level of veterinary clinical evidence and pharmacokinetic data as well as studies in humans and basic research studies.Conclusions and Clinical RelevanceSuccessful management of seizure emergencies should include an early, rapid, and stage‐based treatment approach consisting of interventions with moderate to preferably high ACVIM recommendations; management of complications and underlying causes related to seizure emergencies should accompany antiseizure medications.

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“…Lower doses may be sufficient given the severity of paralysis experienced by patients with elapid envenomation ( 5 , 75 ). Recognized adverse effects include hypotension and Heinz body anemia in cats receiving multi-dosing or CRIs ( 76 , 77 ).…”

Section: Anesthetic Considerationsmentioning

confidence: 99%

Mechanical ventilation in snake envenomation of dogs and cats

Morris¹,

Donaldson²

2023

Front. Vet. Sci.

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Envenomation by snakes in Elapidae and Viperidae families have been associated with respiratory failure in dogs and cats. Mechanical ventilation may be required for hypoventilation due to neuromuscular paralysis or hypoxemia due to pulmonary hemorrhage or aspiration pneumonia. Median incidence of dogs and cats with snake envenomation that require mechanical ventilation is 13% (0.06–40%). Standard treatment of snake envenomation in dogs and cats includes prompt administration of appropriate antivenom and management of envenomation complications such as coagulopathy, rhabdomyolysis and acute kidney injury. When mechanical ventilation is required, overall prognosis is good with appropriate treatment. Standard anesthetic protocols and mechanical ventilator settings are generally appropriate, with lung protective ventilation strategies typically reserved for patients with pulmonary disease. Median survival to discharge for cats and dogs with elapid envenomation is 72% (76–84%) with 33 h (19.5–58 h) median duration of mechanical ventilation and 140 h (84–196 h) median hospitalization. This article reviews indications for mechanical ventilation in cats and dogs with snake envenomation, and discusses ventilator settings, anesthetic and nursing considerations, complications and outcomes specific to this disease.

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Clinical Heinz Body Anemia in a Cat After Repeat Propofol Administration Case Report

Cited by 11 publications

References 6 publications

Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524

Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524

ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats

Mechanical ventilation in snake envenomation of dogs and cats

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