Clinical, haematological, and serum biochemical alterations due to spontaneously occurring pulmonary hypertension syndrome in broiler chicken reared under temperate climatic conditions of Northern Himalayas

Janwari, Anisa Qadir; Mir, Masood Saleem; Amin, Umar; Baba, Omer Khalil; Mariam, Abha; Shah, Showkat Ahmad; Shafi, Majid; Khan, Hilal Musadiq; Kamil, Shayaib Ahmad

doi:10.1007/s00580-018-2775-5

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…Pulmonary hypertension syndrome is known as a disease with multifactorial pathogenesis that thyroid hormones and their receptors could be one of its crucial factors ( Hassanzadeh et al., 2014 ; Janwari et al, 2018 ). The data determined that cold stress could increase thyroid hormones and the gene expression of their receptor (THRα) in the pick of chicken growth (21 d) that they themselves elevates the expression of many genes related to contractile elements (MHCα, RYR2, and SERCA2), leading to right ventricle hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

Changes in the expression of cardiac genes responsive to thyroid hormones in the chickens with cold-induced pulmonary hypertension

et al. 2021

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ASTRACT Cold stress is an environmental cause of pulmonary hypertension syndrome ( PHS ) in broiler chickens. This factor could increase the rate of metabolic activity via thyroid hormones (T3 and T4). To evaluate the effect of these hormones on the heart, the plasma concentration of T3, T4, and the gene expression of their receptors (THRα and THRβ) and many contractile proteins (ACTC1, MHCα, MHCβ, RYR2, SERCA2, THRα, THRβ, and troponin I) were measured in the right ventricle in 2 periods of age (21 and 35 d). Plasma T3 concentration was significantly higher in the PHS group of chickens than in the control one at 21 and 35 d while plasma T4 did not change. The relative expression of MHCα, RYR2, SERCA2, and THRα genes in the right ventricle tissues was only higher in PHS group of broilers than control group at 21 d ( P < 0.05) whereas the expression of ACTC1, MHCβ, and troponin I did not differ at 2 periods of age. The positive correlations between MHCα, RYR2, SERCA2, and T3, THRα were confirmed. The expression of THRβ gene was only higher in PHS group of broilers than control at 35 d ( P < 0.05). The data determined that cold stress could increase thyroid hormones and the gene expression of their receptor (THRα) in the pick of chicken growth (21 d) that they themselves elevates the expression of many genes related to contractile elements (MHCα, RYR2, and SERCA2), leading to adaptive right ventricle hypertrophy.

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Section: Discussionmentioning

confidence: 99%

Changes in the expression of cardiac genes responsive to thyroid hormones in the chickens with cold-induced pulmonary hypertension

et al. 2021

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“…A ocorrência de sinais como anorexia, apatia, dispneia, taquipneia, dificuldade de locomoção e presença de mucosas cianóticas como observado no paciente desse estudo, tem sido relacionado como sinais clínicos da síndrome ascítica (Janwari et al, 2018;Nishanth et al, 2022). Ademais, o aumento do volume da cavidade abdominal com aspecto de fluido livre perceptível a palpação, é considerado o principal sinal característico da doença (Biswas, 2019;LI et al, 2022).…”

Section: Resultsunclassified

“…Ademais, o aumento do volume da cavidade abdominal com aspecto de fluido livre perceptível a palpação, é considerado o principal sinal característico da doença (Biswas, 2019;LI et al, 2022). Se não tratada de maneira apropriada, essa condição pode resultar no óbito do animal (Kamely et al, 2015;Janwari et al, 2018).…”

Section: Resultsunclassified

Aspectos clínicos e terapêuticos da síndrome ascítica em galinha garnisé (Gallus gallus) (Linnaeus, 1758) – relato de caso

Santos,

Oliveira,

Silva

et al. 2024

Braz. J. Anim. Environ. Res.

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A síndrome ascítica é uma condição multifatorial que afeta aves domésticas e silvestres, caracterizada pelo acúmulo anormal de fluido na cavidade abdominal. É uma preocupação significativa na avicultura devido ao seu impacto na saúde e no desempenho das aves. Por esse motivo, o presente estudo teve como objetivo relatar os aspectos clínicos e terapêuticos da síndrome ascítica em galinha garnisé. Foi encaminhada à Clínica Veterinária Escola da Universidade Federal de Sergipe - Campus do Sertão, uma galinha garnisé adulta, fêmea, pesando 1,280 kg, devido à presença de secreção na cloaca. No exame físico, foram observados edema e secreção esbranquiçada na região cloacal. Com isso, inicialmente foi preconizado o uso de Fembendazol, porém, após 24 dias, houve um aumento significativo de peso e agravamento dos sinais clínicos, levando à instituição de Meloxicam, Enrofloxacina e assepsia com Clorexidina 2%, seguido de internamento. Apesar do tratamento, a galinha continuou a ganhar peso e apresentou sinais de dispneia e prostração. Após a falha inicial do tratamento, foram realizadas diversas intervenções, incluindo lavagem da região cloacal, administração de Ocitocina e Cálcio, além da celiocentese para drenagem do líquido ascítico. Este último procedimento resultou em uma melhora significativa do quadro clínico apresentado, reduzindo o seu peso para 1,039 kg. Portanto, o emprego de protocolos terapêuticos apropriados sugere a possibilidade de reversão do quadro clínico em pacientes suscetíveis a essa condição, superando desafios que podem comprometer a recuperação.

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“…Broilers developing PHS showed the high amounts of free radicals in the cardiopulmonary tissues, which led the disease to be worsened (Biswas, 2019 ; Singh et al., 2018 ). Previous studies demonstrated the negative effect of free radicals on the cardiovascular and gastrointestinal systems of pulmonary hypertensive chickens (Baghbanzadeh & Decuypere, 2008 ; Janwari et al., 2018 ). We hypothesize that sage with its useful effects may modulate the pulmonary hypertensive response due to cold stress.…”

Section: Introductionmentioning

confidence: 93%

Effect of sage (Salvia officinalis L.) extract in antioxidant status and intestinal morphology of pulmonary hypertensive chickens

Bahadoran

Teymouri

Hassanpour

et al. 2022

Veterinary Medicine & Sci

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ObjectivesThe effects of dietary sage on the growth performance, antioxidant status, intestinal mucosa morphology, and pulmonary hypertensive response were investigated in broiler chickens with pulmonary hypertension.MethodsChicks (Ross 308) were reared under cold stress for 35 days and treated with 0.05% vitamin C (positive control) and 0 (control), 0.1 or 0.2% sage extracts, then performance, oxidant and antioxidant status, and intestinal morphology were evaluated.ResultsThe index of pulmonary hypertension (RV:TV) was decreased, and weight gain (days 22–35) was increased in all treatments (except for sage 0.1%) compared with control (P < 0.05). Lipid peroxidation was decreased, whereas the activity of antioxidant enzymes (GPX, CAT, and SOD) was increased in the sage 0.2% group compared with control (P < 0.05). In the lung, SOD, CAT, and GPX transcripts were decreased in the sage 0.2% group compared with control (P < 0.05). In the right ventricle of the heart, SOD and CAT transcripts were increased in the sage 0.2% group compared with other groups of chickens, whereas GPX transcript was decreased (P < 0.05). The jejunal villus length in the chickens fed sage was significantly lower than in control (P < 0.05). The ileal villus width, villus surface area, and lamina proporia thickness in the chickens fed sage (0.2%) were increased compared with control (P < 0.05).ConclusionsDietary supplementation of sage (0.2%) could modulate pulmonary hypertensive response, improve antioxidant status (enzymatic activity), intestinal morphometry, and absorptive surface in the broiler chickens.

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Clinical, haematological, and serum biochemical alterations due to spontaneously occurring pulmonary hypertension syndrome in broiler chicken reared under temperate climatic conditions of Northern Himalayas

Cited by 7 publications

References 26 publications

Changes in the expression of cardiac genes responsive to thyroid hormones in the chickens with cold-induced pulmonary hypertension

Changes in the expression of cardiac genes responsive to thyroid hormones in the chickens with cold-induced pulmonary hypertension

Aspectos clínicos e terapêuticos da síndrome ascítica em galinha garnisé (Gallus gallus) (Linnaeus, 1758) – relato de caso

Effect of sage (Salvia officinalis L.) extract in antioxidant status and intestinal morphology of pulmonary hypertensive chickens

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