Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5-year experience

Lichen Planus Affecting the Lips

“…This phenomenon is more common in intra-oral sites: a series of twenty-four cases of SCC arising on oral LP lesions did not show any case of labial compromise [17]. Scarring is the main predisposing factor for SCC occurring secondary to inflammatory disorders.…”

“…Lip cancer is believed to be UV-influenced, and oral cancer is believed to be tobbaco influenced in most cases. It is not known if the concomitant presence of LP might interact with these predisposing factors [17].…”

“…The ointment must be applied twice daily, but use may be increased to four times daily until remission or symptomatic relief [21][22][23][24][25][26]. There are a few reports about these drugs on labial LP [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Oral lichen planus: A look from diagnosis to treatment.

“…27,32,33,35 In particular, erythematous and erosive forms of OLP are most likely considered to malignify, although the evidence for this hypothesis is weak. From different intraoral sites, tongue seems to be the preferred place for malignant transformation, according to observations by Tizeira Lanfranchi et al 31 Nevertheless, Mignogna et al 25 reported an increase in the frequency of carcinomas in the midline palate, gums and lips; and, conversely, Rajentheran et al 36 indicated the buccal mucosa as the most affected area.…”

“…However, this phenomenon is still the subject of much controversy. [24][25][26][27] Literature contains a growing number of clinical series in relation to the malignant potential of OLP, although some authors question the current evidence. [28][29][30] Since 1910, when the first case of oral squamous cell carcinoma (OSCC) in a patient with OLP was reported, these published series have displayed a malignancy rate of 0 to 12.5%.…”