Clinical guidelines for the management of cancer patients with neutropenia and unexplained fever

Huang, Xiao‐Jun; Zhixiang, Shen; Wang, Chun; Reksodiputro, Ary Harryanto; Ranuhardy, Dody; Tamura, Kazuo; Matsumoto, Tetsuro; Lee, Dong Gun; Purushotaman, S. Visalachy; Lim, Victor L.; Ahmed, Altaf; Hussain, Yasser; Chua, Manolito; Ong, A.; Liu, Cheng Yi; Hsueh, Po-Ren; Lin, Shaeng Fung; Liu, Yung Ching; Suwangool, P; Jootar, Saengsuree; Picazo, Juan J.

doi:10.1016/j.ijantimicag.2005.08.007

Cited by 23 publications

(23 citation statements)

References 14 publications

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“…Severely ill patients in intensive care units (ICU) are frequently at risk of developing fungal infections. This has led to the empirical prescription of antifungal agents when the initial antibiotic treatment fails [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic–pharmacodynamic study of itraconazole in patients with fungal infections in intensive care units

Hagihara

Kasai²,

Umemura

et al. 2011

Journal of Infection and Chemotherapy

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetic–pharmacodynamic study of itraconazole in patients with fungal infections in intensive care units

Hagihara

Kasai²,

Umemura

et al. 2011

Journal of Infection and Chemotherapy

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“…Febrile neutropenia is a potentially life-threatening complication of chemotherapy requiring hospitalization and empirical broad-spectrum intravenous antibiotics [11,13,22]. However, only a small proportion of patients develop serious morbidity.…”

Section: Introductionmentioning

confidence: 99%

Oral moxifloxacin or intravenous ceftriaxone for the treatment of low-risk neutropenic fever in cancer patients suitable for early hospital discharge

Sebban

Dussart

Fuhrmann

et al. 2008

Support Care Cancer

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“…Major foreign guidelines, including those of IDSA and NCCN, define fever as an increase in oral temperature to over 38.3℃ once or to 38.0℃ for more than 1 hour [2,3,11,19,22]. In the questionnaire survey conducted with 33 medical staff members in 28 hospitals in Korea, 79% of the respondents answered that fever was defined as an increase in body temperature in two locations to over 38.0℃ or an increase in body temperature to over 38.0℃ for 1-2 hours [29].…”

Section: Definition Of Neutropenia and Fevermentioning

confidence: 99%

“…For a systematic literature review, the latest guidelines of Infectious Diseases Society of America (IDSA) [2], National Comprehensive Cancer Network (NCCN) [3], the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) [4-13], the First European Conference on Infections in Leukaemia (ECIL-1) [14-18], Asia-Pacific [19], and Japan [20-27] were collected. To search the literature published after the publication of the IDSA guidelines (2002), which are relatively widely used, the PubMed (www.pubmed.gov) search engine was used.…”

Section: Introductionmentioning

confidence: 99%

Evidence-Based Guidelines for Empirical Therapy of Neutropenic Fever in Korea

Lee

Kim

et al. 2011

Korean J Intern Med

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Neutrophils play an important role in immunological function. Neutropenic patients are vulnerable to infection, and except fever is present, inflammatory reactions are scarce in many cases. Additionally, because infections can worsen rapidly, early evaluation and treatments are especially important in febrile neutropenic patients. In cases in which febrile neutropenia is anticipated due to anticancer chemotherapy, antibiotic prophylaxis can be used, based on the risk of infection. Antifungal prophylaxis may also be considered if long-term neutropenia or mucosal damage is expected. When fever is observed in patients suspected to have neutropenia, an adequate physical examination and blood and sputum cultures should be performed. Initial antibiotics should be chosen by considering the risk of complications following the infection; if the risk is low, oral antibiotics can be used. For initial intravenous antibiotics, monotherapy with a broad-spectrum antibiotic or combination therapy with two antibiotics is recommended. At 3-5 days after beginning the initial antibiotic therapy, the condition of the patient is assessed again to determine whether the fever has subsided or symptoms have worsened. If the patient's condition has improved, intravenous antibiotics can be replaced with oral antibiotics; if the condition has deteriorated, a change of antibiotics or addition of antifungal agents should be considered. If the causative microorganism is identified, initial antimicrobial or antifungal agents should be changed accordingly. When the cause is not detected, the initial agents should continue to be used until the neutrophil count recovers.

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Clinical guidelines for the management of cancer patients with neutropenia and unexplained fever

Cited by 23 publications

References 14 publications

Pharmacokinetic–pharmacodynamic study of itraconazole in patients with fungal infections in intensive care units

Pharmacokinetic–pharmacodynamic study of itraconazole in patients with fungal infections in intensive care units

Oral moxifloxacin or intravenous ceftriaxone for the treatment of low-risk neutropenic fever in cancer patients suitable for early hospital discharge

Evidence-Based Guidelines for Empirical Therapy of Neutropenic Fever in Korea

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