Clinical Guideline for Female Lower Urinary Tract Symptoms

Takahashi, Satoru; Takei, Makoto; Nishizawa, Osamu; Yamaguchi, Osamu; Kato, Kumiko; Gotoh, Momokazu; Yoshimura, Yuji; Takeyama, Masami; Ozawa, Hideo; Shimada, Makoto; Yamanishi, Tomonori; Yoshida, Masaki; Tomoe, Hikaru; Yokoyama, Osamu; Koyama, Masayasu

doi:10.1111/luts.12111

Cited by 47 publications

(131 citation statements)

References 362 publications

(478 reference statements)

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…The OABSS analysis set consisted of patients who did not have diseases/conditions excluded from OAB diagnosis (abnormal bladder [bladder cancer, bladder calculus, or interstitial cystitis], perivesical abnormalities [endometriosis etc. ], prostatic/urethral abnormalities [prostate cancer or urethral calculus], urinary tract genital infections [bacterial cystitis, prostatitis, or urethritis], or urinary retention, polyuria, or psychogenic pollakiuria) and were judged to have OAB based on the OABSS (OABSS question 3 ≥2 points at baseline and total OABSS ≥3 points at baseline), who were given mirabegron in accordance with the dosing regimen, and who were assessed for OABSS at baseline and final assessment without missing data.…”

Section: Methodsmentioning

confidence: 99%

Safety, efficacy, and persistence of long‐term mirabegron treatment for overactive bladder in the daily clinical setting: Interim (1‐year) report from a Japanese post‐marketing surveillance study

Kato

Tabuchi

Uno

2017

LUTS

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Safety, efficacy, and persistence of long‐term mirabegron treatment for overactive bladder in the daily clinical setting: Interim (1‐year) report from a Japanese post‐marketing surveillance study

Kato

Tabuchi

Uno

2017

LUTS

View full text Add to dashboard Cite

show abstract

“…International urological associations recommend MIRA and antimuscarinics for treating patients with OAB symptoms . However, even when favorable results are achieved in clinical studies, poor responses might be noted in the real‐world setting .…”

Section: Introductionmentioning

confidence: 99%

Long‐term safety and efficacy of antimuscarinic add‐on therapy in patients with overactive bladder who had a suboptimal response to mirabegron monotherapy: A multicenter, randomized study in Japan (MILAI II study)

Yamaguchi

Κakizaki²,

Homma

et al. 2018

Int J of Urology

Self Cite

View full text Add to dashboard Cite

Objectives To evaluate the long‐term safety (primary objective) and efficacy (secondary objective) of antimuscarinic add‐on therapy in patients receiving mirabegron. Methods During a 2‐week screening period, patients (aged ≥20 years, mirabegron treatment for ≥6 weeks, residual overactive bladder symptoms) received mirabegron 50 mg once daily. These patients were subsequently randomized to 52 weeks’ treatment with mirabegron 50 mg/day plus an antimuscarinic (solifenacin 5 mg, propiverine 20 mg, imidafenacin 0.2 mg, or tolterodine 4 mg) with the potential to double the antimuscarinic dose (except for tolterodine) at week 8. Safety assessments included treatment‐emergent adverse events, vital signs, 12‐lead electrocardiograms, post‐void residual volume, and laboratory evaluations. Efficacy was assessed using changes from baseline in overactive bladder symptom score total score; overactive bladder questionnaire short form score; micturitions, urgency episodes, urinary incontinence episodes, and urgency urinary incontinence episodes/24 h; mean volume voided per micturition; and number of night‐time micturitions. Results Overall, 80.2% of patients (88.1% women, mean age 65 years) experienced at least one treatment‐emergent adverse event, with similar rates for all treatments. The adverse events most commonly reported were dry mouth, nasopharyngitis, and constipation. No marked change was observed in systolic or diastolic blood pressure for any treatment, although pulse rate increased slightly in the mirabegron and propiverine, and mirabegron and tolterodine groups. For all treatments, significant improvements were observed in all efficacy parameters, including overactive bladder symptom score total and questionnaire short form scores. Conclusions Antimuscarinic add‐on therapy is well tolerated and effective after initial treatment with mirabegron in patients with overactive bladder symptoms.

show abstract

“…However, in Brazil, urinalysis and urine culture are frequently requested together despite the lack of appropriate indication. 13 …”

Section: Introductionmentioning

confidence: 99%

Performance of the dipstick screening test as a predictor of negative urine culture

Marques

Doi

Pasternak

et al. 2017

Einstein (São Paulo)

View full text Add to dashboard Cite

Objective To investigate whether the urine dipstick screening test can be used to predict urine culture results.Methods A retrospective study conducted between January and December 2014 based on data from 8,587 patients with a medical order for urine dipstick test, urine sediment analysis and urine culture. Sensitivity, specificity, positive and negative predictive values were determined and ROC curve analysis was performed.Results The percentage of positive cultures was 17.5%. Nitrite had 28% sensitivity and 99% specificity, with positive and negative predictive values of 89% and 87%, respectively. Leukocyte esterase had 79% sensitivity and 84% specificity, with positive and negative predictive values of 51% and 95%, respectively. The combination of positive nitrite or positive leukocyte esterase tests had 85% sensitivity and 84% specificity, with positive and negative predictive values of 53% and 96%, respectively. Positive urinary sediment (more than ten leukocytes per microliter) had 92% sensitivity and 71% specificity, with positive and negative predictive values of 40% and 98%, respectively. The combination of nitrite positive test and positive urinary sediment had 82% sensitivity and 99% specificity, with positive and negative predictive values of 91% and 98%, respectively. The combination of nitrite or leukocyte esterase positive tests and positive urinary sediment had the highest sensitivity (94%) and specificity (84%), with positive and negative predictive values of 58% and 99%, respectively. Based on ROC curve analysis, the best indicator of positive urine culture was the combination of positives leukocyte esterase or nitrite tests and positive urinary sediment, followed by positives leukocyte and nitrite tests, positive urinary sediment alone, positive leukocyte esterase test alone, positive nitrite test alone and finally association of positives nitrite and urinary sediment (AUC: 0.845, 0.844, 0.817, 0.814, 0.635 and 0.626, respectively).Conclusion A negative urine culture can be predicted by negative dipstick test results. Therefore, this test may be a reliable predictor of negative urine culture.

show abstract

Clinical Guideline for Female Lower Urinary Tract Symptoms

Cited by 47 publications

References 362 publications

Safety, efficacy, and persistence of long‐term mirabegron treatment for overactive bladder in the daily clinical setting: Interim (1‐year) report from a Japanese post‐marketing surveillance study

Safety, efficacy, and persistence of long‐term mirabegron treatment for overactive bladder in the daily clinical setting: Interim (1‐year) report from a Japanese post‐marketing surveillance study

Long‐term safety and efficacy of antimuscarinic add‐on therapy in patients with overactive bladder who had a suboptimal response to mirabegron monotherapy: A multicenter, randomized study in Japan (MILAI II study)

Performance of the dipstick screening test as a predictor of negative urine culture

Contact Info

Product

Resources

About