Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: Results from a multicenter, international and retrospective study

Bartoloni, Elena; González-Gay, Miguel Á.; Scirè, Carlo Alberto; Castañeda, Santos; Gerli, Roberto; López‐Longo, Francisco Javier; Martínez-Barrio, Julia; Govoni, Marcello; Furini, Federica; Pina, Trinitario; Iannone, Florenzo; Giannini, Margherita; Nuño, Laura; Quartuccio, Luca; Ortego-Centeno, Norbérto; Alunno, Alessia; Specker, Christof; Montecucco, Carlomaurizio; Triantafyllias, Konstantinos; Balduzzi, Silvia; Sifuentes‐Giraldo, Walter Alberto; Paolazzi, Giuseppe; Bravi, Elena; Schwarting, Andreas; Pellerito, Raffaele; Russo, Alessandra; Selmi, Carlo; Saketkoo, Lesley Ann; Fusaro, Enrico; Parisi, Simone; Pipitone, Nicolò; Franceschini, Franco; Cavazzana, Ilaria; Neri, R; Barsotti, Simone; Codullo, Veronica; Cavagna, Lorenzo

doi:10.1016/j.autrev.2017.01.008

Cited by 52 publications

(43 citation statements)

References 27 publications

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“…Prospective studies are needed to confirm this finding and to evaluate the possible value of NVC in the prediction of interstitial lung involvement. This point is not a secondary issue, because together with other clinical aspects such as the occurrence of de novo accompanying findings during followup 18 , NVC could result in an easily obtainable marker providing additional information on the degree of risk for the clinical spectrum progression in patients with AS.…”

Section: Discussionmentioning

confidence: 99%

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Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study

et al. 2018

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Objective.To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease.Methods.We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non–anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody–negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures.Results.NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP.Conclusion.NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.

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Section: Discussionmentioning

confidence: 99%

“…By considering the relevance of accompanying findings in general and of RP in particular in AS 18 , this multicenter study (Nailfold Capillaroscopy in Antisynthetase Syndrome) aimed to describe the capillaroscopic features from a well-characterized cohort of patients, investigating possible correlations with clinical and serological features of the disease.…”

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Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study

et al. 2018

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“…Antisynthetase syndrome is characterized by the classic triad of myositis, arthritis, and interstitial lung disease (ILD). However, initially it often presents with an atypical or incomplete clinical picture with only 1 or 2 of the aforementioned manifestations, with the complete triad emerging as the disease evolves . Arthritis is an important component of antisynthetase syndrome , with a prevalence of 55% in the incomplete forms in our series .…”

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confidence: 80%

Consideration of Antisynthetase Syndrome Features in Classifying Patients as Having Idiopathic Inflammatory Myopathy: Comment on the Article by Lundberg et al

Castañeda

Cavagna

2018

Arthritis & Rheumatology

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“…Its onset later in the disease course may herald the fl are-up of interstitial lung disease. 1 A similar hyperkeratosis may also affect the feet, and the importance of a careful cutaneous examination of the hands and feet should be stressed in patients presenting with polymyositis and dermatomyositis.…”

Section: ■ Antisynthetase Syndromementioning

confidence: 99%

Hyperkeratotic fissured plaques on both hands: Mechanic’s hands

Bishnoi

Parsad

2018

CCJM

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A housewife in her 50s presented with photosensitivity and recent-onset roughness on her index fi ngers and thumbs. Examination showed asymptomatic, bilaterally symmetrical, hyperkeratotic, scaly, fi ssured plaques with hyperpigmentation on the radial aspect of the index fi nger of both hands, extending to the ulnar aspect of the thumbs and sparing the palmar aspect of both (Figure 1). Palms, soles, and other fi ngers were normal.Nail fold capillaroscopy did not reveal telangiectasia or ragged cuticles. Further examination of the skin showed confl uent macular violaceous erythema on the eyelids (suggestive of the heliotrope sign), V area of the neck, upper arms, and back.She also had a low-grade intermittent fever for the past 2 months, as well as difficulty in getting up from a squatting position and combing her hair, dyspnea on exertion, blue discoloration of the fi ngers on exposure to cold, and intermittent pain, stiffness, and swelling in the small joints of both hands that was worse in the morning and seemed to be relieved by activity. She had no history of dysphagia or nasal regurgitation of food. Strength against resistance was reduced in both arms and knee extensors. A diagnosis of dermatomyositis with "mechanic's hands" was considered.Laboratory testing was negative for antinuclear antibodies and showed elevated creatine kinase and positive anti-Jo-1 antibodies. High-resolution computed tomography of the chest showed evidence of interstitial lung disease. Features were consistent with antisynthetase syndrome and dermatomyositis. An age-appropriate malignancy screen was normal. THE CLINICAL PICTURE

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Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: Results from a multicenter, international and retrospective study

Cited by 52 publications

References 27 publications

Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study

Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study

Consideration of Antisynthetase Syndrome Features in Classifying Patients as Having Idiopathic Inflammatory Myopathy: Comment on the Article by Lundberg et al

Hyperkeratotic fissured plaques on both hands: Mechanic’s hands

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