Clinical findings, course, and progress of Bietti's corneal degeneration in the Dahlak islands.

Rodger, F. C.

doi:10.1136/bjo.57.9.657

Cited by 41 publications

(27 citation statements)

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“…Further, the conjunctival site was found to predominate, greatly exceeding the corneal even within regions with maximum corneal location. The investigation did not bear out the view held by Rodger (1973) of a difference between Red Sea keratopathy and Arctic keratopathy. On the contrary, the conjunctival spheroid, the corneal spheroid, the band-shaped microspheroid, and climate-keratopathy grades I to I1 I all seem to represent different grades of the same disorder.…”

Section: Discussionmentioning

confidence: 85%

Spheroid Degeneration, Pinguecula, and Pterygium Among Arabs in the Red Sea Territory, Jordan

Norn¹

1982

Acta Ophthalmologica

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Report of an examination of 127 Arabs in the Red Sea City of Aqaba, Jordan. The results are compared with those of the author's examinations, using a similar apparatus, of 659 Eskimos in Western Greenland and 810 Caucasians in Copenhagen. Ultraviolet (u.v.) light is at a maximum in the Red Sea territory, considerable in Greenland, and negligible in Copenhagen. The prevalences of the following degenerative processes are high at the Red Sea, somewhat lower in Greenland, and low in Copenhagen: Climato-keratopathy gr. III (across the cornea, often with autofluorescent spheroids, always with conjunctival location as well), conjunctival spheroids (39%), and pinguecula (90% at the Red Sea). The prevalence of the conjunctival spheroid degeneration greatly exceeds that of the corneal. No difference is demonstrable between tropical and arctic keratopathy. The investigations performed gave results bearing out the view that u.v. light is responsible for all the above degenerative processes. Pterygium is equally frequent at the Red Sea and in Greenland. Lipid deposits (6%) and scleral plaques are not more prevalent at the Red Sea, a fact which argues against an ultraviolet genesis.

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Section: Discussionmentioning

confidence: 85%

Spheroid Degeneration, Pinguecula, and Pterygium Among Arabs in the Red Sea Territory, Jordan

Norn¹

1982

Acta Ophthalmologica

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“…The crystals often present in the superior or inferior limbus first, and then spread to the entire corneal limbus. Corneal crystalline deposits may also disappear to progress to corneal degeneration, keratopathy, or scar formation 3,40,45…”

Section: Cytoplasmic Crystalline Inclusionsmentioning

confidence: 99%

“…In 2004, Mataftsi et al reported that the prevalence of BCD in a reference population of retinitis pigmentosa (RP) patients was 3% in non-syndromic RP cases and 10% in autosomal recessive RP patients 4. To date, over 100 cases have been reported with an apparent higher prevalence in Asian descent populations 3–45…”

Section: Introductionmentioning

confidence: 99%

Evolution of Cellular Inclusions in Bietti’s Crystalline Dystrophy

Furusato

Cameron

Chan

2010

OED

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Bietti’s crystalline dystrophy (BCD) consists of small, yellow-white, glistening intraretinal crystals in the posterior pole, tapetoretinal degeneration with atrophy of the retinal pigment epithelium (RPE) and “sclerosis” of the choroid; in addition, sparking yellow crystals in the superficial marginal cornea are also found in many patients. BCD is inherited as an autosomal-recessive trait (4q35-tel) and usually has its onset in the third decade of life. This review focuses on the ultrastructure of cellular crystals and lipid inclusions of BCD.

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“…Intense constant winds, lack of shade, low humidity and UVR exposure in hot as well as cold arid climates are the more common environmental factors observed in areas with high prevalence of the disease. For these reasons, CDK is considered a rural and an outdoor labor disease, and very rarely affects urban individuals [3,4,16,17,18,19,20]. In fact, this disease occurs frequently in indigenous populations of the Americas that inhabit these kinds of environments [1,3,4,16,21,22].…”

Section: Introductionmentioning

confidence: 99%

Genetic Background and Climatic Droplet Keratopathy Incidence in a Mapuche Population from Argentina

et al. 2013

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PurposeTo determine whether the incidence of and susceptibility to climatic droplet keratopathy (CDK), an acquired, often bilateral degenerative corneal disease, is influenced by the genetic background of the individuals who exhibit the disorder.MethodsTo determine whether the disease expression was influenced by the genetic ancestry of CDK cases in native Mapuche of the northwest area of Patagonia in Argentina, we examined mitochondrial DNA and Y-chromosome variation in 53 unrelated individuals. Twenty-nine of them were part of the CDK (patient) population, while 24 were part of the control group. The analysis revealed the maternal and paternal lineages that were present in the two study groups.ResultsThis analysis demonstrated that nearly all persons had a Native American mtDNA background, whereas 50% of the CDK group and 37% of the control group had Native American paternal ancestry, respectively. There was no significant difference in the frequencies of mtDNA haplogroups between the CDK patient and control groups. Although the Y-chromosome data revealed differences in specific haplogroup frequencies between these two groups, there was no statistically significant relationship between individual paternal genetic backgrounds and the incidence or stage of disease.ConclusionsThese results indicate a lack of correlation between genetic ancestry as represented by haploid genetic systems and the incidence of CDK in Mapuche populations. In addition, the mtDNA appears to play less of a role in CDK expression than for other complex diseases linked to bioenergetic processes. However, further analysis of the mtDNA genome sequence and other genes involved in corneal function may reveal the more precise role that mitochondria play in the expression of CDK.

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Clinical findings, course, and progress of Bietti's corneal degeneration in the Dahlak islands.

Cited by 41 publications

References 4 publications

Spheroid Degeneration, Pinguecula, and Pterygium Among Arabs in the Red Sea Territory, Jordan

Spheroid Degeneration, Pinguecula, and Pterygium Among Arabs in the Red Sea Territory, Jordan

Evolution of Cellular Inclusions in Bietti’s Crystalline Dystrophy

Genetic Background and Climatic Droplet Keratopathy Incidence in a Mapuche Population from Argentina

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Clinical findings, course, and progress of Bietti's corneal degeneration in the Dahlak islands.

Cited by 41 publications

References 4 publications

Spheroid Degeneration, Pinguecula, and Pterygium Among Arabs in the Red Sea Territory, Jordan

Spheroid Degeneration, Pinguecula, and Pterygium Among Arabs in the Red Sea Territory, Jordan

Evolution of Cellular Inclusions in Bietti&rsquo;s Crystalline Dystrophy

Genetic Background and Climatic Droplet Keratopathy Incidence in a Mapuche Population from Argentina

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Product

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Evolution of Cellular Inclusions in Bietti’s Crystalline Dystrophy