Clinical findings associated with abnormal lung function in children aged 3–26 months with recurrent respiratory symptoms

Pelkonen, Antti; Kotaniemi‐Syrjänen, Anne; Malmström, Kristiina; Malmberg, L. Pekka; Mäkelä, Mika J.

doi:10.1111/j.1651-2227.2010.01790.x

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…Whole body plethysmography is not frequently used in infants due to its complexity and the necessity of highly trained staff. Nonetheless, it has been shown to be able to determine the severity of respiratory disorder in infancy (Kjaer et al 2008, Pelkonen et al 2010, Robin et al 2004 and to identify air trapping.…”

Section: Clinical Findings and Interpretationmentioning

confidence: 99%

Pulmonary function testing in children and infants

Vogt¹,

Falkenberg²,

Weiler³

et al. 2014

Physiol. Meas.

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Pulmonary function testing is performed in children and infants with the aim of documenting lung development with age and making diagnoses of lung diseases. In children and infants with an established lung disease, pulmonary function is tested to assess the disease progression and the efficacy of therapy. It is difficult to carry out the measurements in this age group without disturbances, so obtaining results of good quality and reproducibility is challenging. Young children are often uncooperative during the examinations. This is partly related to their young age but also due to the long testing duration and the unpopular equipment. We address a variety of examination techniques for lung function assessment in children and infants in this review. We describe the measuring principles, examination procedures, clinical findings and their interpretation, as well as advantages and limitations of these methods. The comparability between devices and centres as well as the availability of reference values are still considered a challenge in many of these techniques. In recent years, new technologies have emerged allowing the assessment of lung function not only on the global level but also on the regional level. This opens new possibilities for detecting regional lung function heterogeneity that might lead to a better understanding of respiratory pathophysiology in children.

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Section: Clinical Findings and Interpretationmentioning

confidence: 99%

Pulmonary function testing in children and infants

Vogt¹,

Falkenberg²,

Weiler³

et al. 2014

Physiol. Meas.

View full text Add to dashboard Cite

show abstract

“…In addition, reduced lung function was predictive for wheezy symptoms in the following years [61, [71][72][73]. Reduced lung function in infancy was associated with respiratory morbidity and treatment needs at preschool age [65]. Some studies showed improvement of lung function, such as forced expiratory volume in 0.5 s, in infants with recurrent wheezing after ICS treatment or oral treatment with montelukast, whereas others did not show significant changes [63,64,74,75].…”

Section: Infant Lung Functionmentioning

confidence: 99%

“…Different methods have been used to assess lung function in wheezy infants including the analysis of tidal flow-volume breathing loops, forced expirations from either normal inspiration (rapid thoracic compression technique) or from total lung capacity (raised volume rapid thoracic compression technique) or body plethysmography [62][63][64][65][66][67]. Infant lung function testing has been used to assess phenotypes in infants with wheezing and to develop prediction models for persistent asthma [68].…”

Section: Infant Lung Functionmentioning

confidence: 99%

Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation

et al. 2015

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This review focuses on the methods available for measuring reversible airways obstruction, bronchial hyperresponsiveness (BHR) and inflammation as hallmarks of asthma, and their role in monitoring children with asthma. Persistent bronchial obstruction may occur in asymptomatic children and is considered a risk factor for severe asthma episodes and is associated with poor asthma outcome. Annual measurement of forced expiratory volume in 1 s using office based spirometry is considered useful. Other lung function measurements including the assessment of BHR may be reserved for children with possible exercise limitations, poor symptom perception and those not responding to their current treatment or with atypical asthma symptoms, and performed on a higher specialty level. To date, for most methods of measuring lung function there are no proper randomised controlled or large longitudinal studies available to establish their role in asthma management in children.Noninvasive biomarkers for monitoring inflammation in children are available, for example the measurement of exhaled nitric oxide fraction, and the assessment of induced sputum cytology or inflammatory mediators in the exhaled breath condensate. However, their role and usefulness in routine clinical practice to monitor and guide therapy remains unclear, and therefore, their use should be reserved for selected cases. @ERSpublications Review on the role of lung function, measurement of BHR and airway inflammation in monitoring of children with asthma

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“…In infants with wheeze, lung function may be assessed with several techniques, such as the analysis of tidal flow-volume breathing loops [114][115][116], forced expirations (rapid thoracic compression technique or raised volume rapid thoracic compression technique) [115,[117][118][119][120][121] or body plethysmography [122]. Infant lung function testing has been used to define phenotypes in infants with wheeze and to predict treatment effects and prognosis [120,121,[123][124][125]; several studies have tracked lung function from infancy to school age [115-117, 119, 126-131].…”

Section: Infant Lung Functionmentioning

confidence: 99%

Monitoring asthma in children

et al. 2015

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The goal of asthma treatment is to obtain clinical control and reduce future risks to the patient. To reach this goal in children with asthma, ongoing monitoring is essential. While all components of asthma, such as symptoms, lung function, bronchial hyperresponsiveness and inflammation, may exist in various combinations in different individuals, to date there is limited evidence on how to integrate these for optimal monitoring of children with asthma. The aims of this ERS Task Force were to describe the current practise and give an overview of the best available evidence on how to monitor children with asthma.22 clinical and research experts reviewed the literature. A modified Delphi method and four Task Force meetings were used to reach a consensus.This statement summarises the literature on monitoring children with asthma. Available tools for monitoring children with asthma, such as clinical tools, lung function, bronchial responsiveness and inflammatory markers, are described as are the ways in which they may be used in children with asthma. Management-related issues, comorbidities and environmental factors are summarised.Despite considerable interest in monitoring asthma in children, for many aspects of monitoring asthma in children there is a substantial lack of evidence. @ERSpublications ERS statement summarising and discussing the available literature on monitoring children with asthma

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Clinical findings associated with abnormal lung function in children aged 3–26 months with recurrent respiratory symptoms

Cited by 5 publications

References 20 publications

Pulmonary function testing in children and infants

Pulmonary function testing in children and infants

Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation

Monitoring asthma in children

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