Clinical Findings Among Pcb‐exposed Capacitor Manufacturing Workers*

Fischbein, Alf; Wolff, Mary S.; Lilis, Ruth; Thornton, John C.; Selikoff, Irving J.

doi:10.1111/j.1749-6632.1979.tb56645.x

Cited by 128 publications

(52 citation statements)

References 21 publications

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“…On comparing our results with Yusho patients, whose blood PCB levels were slightly higher than those of normal Japanese and were markedly lower than those of capacitor workers, the scarcity of abnormal findings was most impressive, as noted by Fishbein et al (8).…”

Section: Health Status Of Pcb Workersmentioning

confidence: 48%

“…It was noteworthy that, despite the very high blood PCB levels in these capacitor manufacturing workers, abnormal findings other than the dermatological lesions were very rare; we found dermatological changes such as comedones and acne to be the most prevalent abnormalities in other surveys of capacitor workers (7,8,11). Correlation between the blood PCB levels and serum triglycerides was found only in one instance of our eight years follow-up examinations, although elevation of serum triglyceride associated with elevated blood PCB levels was reported in a few studies of PCB workers (9,13).…”

Section: Health Status Of Pcb Workersmentioning

confidence: 88%

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Health Status and PCBs in Blood of Workers Exposed to PCBs and of Their Children

Hara¹

1985

Environmental Health Perspectives

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A follow-up study of capacitor manufacturing workers exposed to polychorinated biphenyls (PCBs) and their children was conducted since 1973. PCB levels in whole blood of workers as well as in breast milk of the exposed lactating mothers were approximately 10 to 100 times those of nonexposed Japanese. Blood PCB levels had a statistically significant correlation with the duration of PCB handling and breast milk PCB levels. The rate of decline of blood PCB levels, as well as the changes of the gas chromatograph of blood PCB over 7 years was found to vary with the kind of PCB handled. The levels of blood PCB tended to be higher in the children fed PCB-contaminated breast milk for a long period. The great majority of workers handling PCBs had dermatologic complaints. Discontinuance of contact with PCB led to gradual improvement of these lesions. Abnormal results in the blood chemistry of the workers were rare, while serum triglyceride concentration was significantly correlated with blood PCB levels in 1974.In the questionnaire study, the number of complaints in children born from mothers who had handled PCBs, especially those fed breast milk for a long period, was conspicuously higher than that in control groups. Several children were found to have the same medical findings as in Yusho; however, they have not been diagnosed as PCB-poisoning, because these findings were neither so serious nor related to the blood PCB levels.

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Section: Health Status Of Pcb Workersmentioning

confidence: 48%

Section: Health Status Of Pcb Workersmentioning

confidence: 88%

Health Status and PCBs in Blood of Workers Exposed to PCBs and of Their Children

Hara¹

1985

Environmental Health Perspectives

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“…In 1977, four more cases of chloracne were diagnosed among 67 workers from the same plant who were engaged in impregnating capacitors with Pyralene 3010 (0.048-0.275 mg/m 3 ) and had skin contact confirmed as a major exposure route. An increased incidence of non-adolescent acneiform eruptions was reported in workers exposed to various Aroclors at mean concentrations of 0.007-11 mg/m 3 for > 5 years; 40% of the workers had been exposed for > 20 years (Fischbein et al 1979(Fischbein et al , 1982. Maroni et al (1981a, b) reported ten cases of acne and/or folliculitis and five cases of dermatitis among 80 capacitor-manufacturing workers in Italy.…”

Section: (A) Human Exposure (I)mentioning

confidence: 99%

Polychlorinated Biphenyls and Polybrominated Biphenyls

Agudo

Aronson²,

Bonefeld-Jörgensen³

et al. 2008

Organic Pollutants

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initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, lifestyle factors and biological and physical agents, as well as those in specific occupations. The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in carcinogenesis and related fields; and to indicate where additional research efforts are needed. The lists of IARC evaluations are regularly updated and are available on the Internet at http:// monographs.iarc.fr/.This programme has been supported since 1982 by Cooperative Agreement U01 CA33193 with the United States National Cancer Institute, Department of Health and Human Services. Additional support has been provided since 1986 by the European Commission Directorate-General for Employment, Social Affairs, and Inclusion, initially by the Unit of Health, Safety and Hygiene at Work, and since 2014 by the European Union Programme for Employment and Social Innovation "EaSI" (2014-2020) The International Agency for Research on Cancer welcomes requests for permission to reproduce or translate its publications, in part or in full. Requests for permission to reproduce or translate IARC publications -whether for sale or for non-commercial distribution -should be addressed to the IARC Communications Group at: publications@iarc.fr.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.The IARC Monographs Working Group alone is responsible for the views expressed in this publication. IARC Library Cataloguing in Publication Data NOTE TO THE READERThe term 'carcinogenic risk' in the IARC Monographs series is taken to mean that an agent is capable of causing cancer. The Monographs evaluate cancer hazards, despite the historical presence of the word 'risks' in the title.Inclusion of an agent in the Monographs does not imply that it is a carcinogen, only that the published data have been examined. Equally, the fact that an agent has not yet been evaluated in a Monograph does not mean that...

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“…Ouw and colleagues (33) reported complaints of a burning sensation of the face and hands, nausea and a persistent body odor in a study of 34 (35,36). Of the subjects examined, 90% were employed for more than 5 years, 40% for 20 years or longer.…”

Section: Chronic Occupational Exposurementioning

confidence: 99%

Symptoms, signs and findings in humans exposed to PCBs and their derivatives.

Reggiani¹,

Bruppacher²

1985

Environ Health Perspect

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The records of the health effects caused by some accidental exposure and findings from medical examination in cases exposed to polybrominated biphenyls (PBB) as well as to polychlorinated biphenyls (PCB) and their derivatives polychlorinated dibenzofurans (PCDF) and dibenzodioxins (PCDD) have provided some information for the recognition and classification of their toxicity in humans. The most impressive clinical features have been presented by the yusho episode of exposure. Dermatologic signs are the most persistent indicator of a considerable uptake. Neurological symptoms, respiratory findings and impairment of liver function are further aspects of the contamination. Skin manifestations have been observed also in the newborn infants from mothers exposed to high levels of the substances. However, the available data make it still hard to assess the clinical picture of the effects on humans in cases of acute exposure and even more the effects on reproduction and long-term effects. Furthermore it would still be arbitrary to draw a line between the symptoms which can be referred to PCBs and PBBs alone and those which can be related qualitatively and quantitatively to PCB derivatives (PCDFs, PCDDs, PCQs).

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Clinical Findings Among Pcb‐exposed Capacitor Manufacturing Workers*

Cited by 128 publications

References 21 publications

Health Status and PCBs in Blood of Workers Exposed to PCBs and of Their Children

Health Status and PCBs in Blood of Workers Exposed to PCBs and of Their Children

Polychlorinated Biphenyls and Polybrominated Biphenyls

Symptoms, signs and findings in humans exposed to PCBs and their derivatives.

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