Clinical features, Outcomes and Molecular Profiles of Drug Resistance in Tuberculous Meningitis in non-HIV Patients

Zhang, Jingya; Hu, Xuejiao; Hu, Xiangyou; Ye, Yuanxin; Shang, Mengqiao; An, Yunfei; Gou, Haimei; Zhao, Zhenzhen; Peng, Wu; Song, Xingbo; Zhou, Yanhong; Kang, Mei; Xie, Yi; Chen, Xuerong; Lu, Xiaojun; Wang, Lanlan

doi:10.1038/srep19072

Cited by 14 publications

(17 citation statements)

References 26 publications

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“…A recent study in Shenzhen, China indicated that, from 2006 to 2012, the proportion of CRF07_BC infections rapidly increased from 12.5% to 43.2%, whereas CRF01_AE and HIV‐1 B infections gradually decreased from 50.0% and 37.5% to 32.3% and 5.7%, respectively. In addition, the percentage of CRF55_01B rapidly increased from 0 in 2006 to 16.0% in 2012 . These results highlight the need to evaluate the natural history and progression of HIV‐1 infection caused by different HIV‐1 genotypes, in particular the two major CRF01_AE and CRF07_BC variants as well as CRF55_01B, which has newly emerged but is rapidly increasing in China.…”

Section: Introductionmentioning

confidence: 95%

HIV‐1 genotype is independently associated with immunodeficiency progression among Chinese men who have sex with men: an observational cohort study

et al. 2019

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ObjectivesHIV-1 genetic diversity is increasing among men who have sex with men (MSM) in China, but the association of HIV-1 genotype with disease progression remains to be elucidated. MethodsWe collected data in an observational longitudinal cohort study of 860 HIV-1-infected MSM in Guangzhou, China between January 2008 and March 2017. Kaplan-Meier analysis and Cox proportional hazard model were used to predict the time from HIV-1 diagnosis to immunodeficiency progression (CD4 cell count < 200 cells/ll) as well as adjusted hazard ratio (aHR). ResultsCRF01_AE and HIV-1 subtype B infection were associated with higher percentage of patients progressed to immunodeficiency and higher incidence of immunodeficiency than infection with CRF07_BC or CRF55_01B. Compared with CRF07_BC, the time from HIV-1 diagnosis to immunodeficiency were different among the major HIV-1 genotypes, which ranked as follows, in descending order: CRF07_BC (7.03 years) > CRF55_01B (5.71 years, P = 0.014; aHR 3.752, P = 0.0923) > CRF01_AE (5.18 years, P < 0.001; aHR 4.733, P = 0.0152). HIV-1 genotype, viral load and baseline CD4 T-cell count were three independent variables associated with disease progression. ConclusionsOur results confirm differential rates of immunodeficiency progression as a function of HIV-1 genotype. The impact of HIV-1 genotype on HIV epidemics, patient management and prevention should be further investigated.

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Section: Introductionmentioning

confidence: 95%

HIV‐1 genotype is independently associated with immunodeficiency progression among Chinese men who have sex with men: an observational cohort study

et al. 2019

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“…Numerous studies have been reported on various other parameters as biomarkers in CSF for the diagnosis of TBM, including a predominance of lymphocytes, decreased glucose level and increased protein level [ 22 ]. Elevated CSF adenosine deaminase (ADA) activity has been observed in TBM patients [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

IgG response to Mycobacterium tuberculosis non-polar lipids and sonicated extracts among tuberculous meningitis patients

Giribhattanavar

Pirson

Kumar

et al. 2020

Access Microbiology

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Introduction. The diagnosis of tuberculous meningitis (TBM) is a major global health concern due to its protean nature. There is a need to identify better biomarkers for the rapid and definitive diagnosis of TBM. Lipids have been poorly explored as diagnostic markers in TBM. Aim. Non-polar lipids (NPL) and mycobacterial sonicate extract (MTSE) antigens were assessed for diagnosis of Mycobacterium tuberculosis . Methodology. A total of 110 cerebrospinal fluid samples were categorized as confirmed, suspected and non-TBM cases according to clinical presentation and laboratory investigations, which were further analysed by NPL and MTSE ELISA. Results. The sensitivity and specificity of the NPL ELISA were 39.6 and 96 %, respectively, whereas the MTSE ELISA was 17 % sensitive and 92 % specific. The combination of the NPL and MTSE ELISA test was superior to these tests alone, with sensitivity and specificity of 43 and 88 %, respectively. Conclusion. This combination may be useful as an adjunct in the laboratory diagnosis of TBM. However, future studies in different settings among different populations, such as those with human immunodeficiency virus co-infection, are desirable to explore the full potential of biomarkers.

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“…It is known that nearly 24.9% of the patients exhibited signs of meningeal irritation in children especially under 3 years of age. The prevalence of all other symptoms and signs were less than 20% [ 39 ]. On the other side, bacterial meningitis is present in 30% of children with signs of meningeal irritation.…”

Section: Methodsmentioning

confidence: 99%

Experts’ opinion about the pediatric secondary headaches diagnostic criteria of the ICHD-3 beta

et al. 2017

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BackgroundThe 2013 International Classification of Headache Disorders-3 was published in a beta version to allow clinicians to confirm the validity of the criteria or suggest improvements based on field studies. The aim of this work was to review the Secondary Headache Disorders and Cranial Neuralgias and Other Headache Disorders sections of ICHD-3 beta data on children and adolescents (age 0–18 years) and to suggest changes, additions, and amendments.MethodsSeveral experts in childhood headache across the world applied different aspects of ICHD-3 beta in their normal clinical practice. Based on their personal experience and the available literature on pediatric headache, they made observations and proposed suggestions for the mentioned headache disorders on children and adolescents.ResultsSome headache disorders in children have specific features, which are different from adults that should be acknowledged and considered. Some features in children were found to be age-dependent: clinical characteristics, risks factors and etiologies have a strong bio psychosocial basis in children and adolescents making primary headache disorders in children distinct from those in adults.ConclusionsSeveral recommendations are presented in order to make ICHD-3 more appropriate for use in children.

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Clinical features, Outcomes and Molecular Profiles of Drug Resistance in Tuberculous Meningitis in non-HIV Patients

Cited by 14 publications

References 26 publications

HIV‐1 genotype is independently associated with immunodeficiency progression among Chinese men who have sex with men: an observational cohort study

HIV‐1 genotype is independently associated with immunodeficiency progression among Chinese men who have sex with men: an observational cohort study

IgG response to Mycobacterium tuberculosis non-polar lipids and sonicated extracts among tuberculous meningitis patients

Experts’ opinion about the pediatric secondary headaches diagnostic criteria of the ICHD-3 beta

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